Joseph Zhao, MBBS, MRCP
Hospital ResidentAbout
Research
Publications
Featured Publications
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases
Zhao J, Ong C, Srivastava S, Chia D, Ma H, Huang K, Sheng T, Ramnarayanan K, Ong X, Tay S, Hagihara T, Tan A, Teo M, Tan Q, Ng G, Tan J, Ng M, Gwee Y, Walsh R, Law J, Shabbir A, Kim G, Tay Y, Her Z, Leoncini G, Teh B, Hong J, Tay R, Teo C, Dings M, Bijlsma M, Lum J, Mathur S, Pietrantonio F, Blum S, van Laarhoven H, Klempner S, Yong W, So J, Chen Q, Tan P, Sundar R. Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases. Gastroenterology 2024, 167: 1384-1398.e4. PMID: 39147169, DOI: 10.1053/j.gastro.2024.08.007.Peer-Reviewed Original ResearchLow Programmed Death-Ligand 1–Expressing Subgroup Outcomes of First-Line Immune Checkpoint Inhibitors in Gastric or Esophageal Adenocarcinoma
Zhao J, Yap D, Chan Y, Tan B, Teo C, Syn N, Smyth E, Soon Y, Sundar R. Low Programmed Death-Ligand 1–Expressing Subgroup Outcomes of First-Line Immune Checkpoint Inhibitors in Gastric or Esophageal Adenocarcinoma. Journal Of Clinical Oncology 2021, 40: 392-402. PMID: 34860570, DOI: 10.1200/jco.21.01862.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis
Ong C, Zhao J, Liu Y, Srivastava S, Chia D, Quek Y, Fan X, Ma H, Huang K, Sheng T, Tan Q, Ng G, Tan J, Lee J, Loo L, Chong L, Ong X, Tay S, Hagihara T, Tan A, Joseph C, Teo M, Hendrikson J, Chong C, Guo W, Chia C, Wong J, Seo C, Cai M, Tay Y, Sim K, Tay R, Walsh R, Guaglio M, Morano F, Teh M, Lum H, Lim T, Vermeulen L, Bijlsma M, Lenos K, Klempner S, Yeong J, Yong W, Pietrantonio F, Tan P, Sundar R. Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis. Clinical Cancer Research 2025, 31: 2515-2529. PMID: 40299767, PMCID: PMC12163601, DOI: 10.1158/1078-0432.ccr-24-3780.Peer-Reviewed Original ResearchSex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors
Nasca V, Zhao J, Ros J, Lonardi S, Zwart K, Cohen R, Fakih M, Jayachandran P, Roodhart J, Derksen J, Intini R, Bergamo F, Mazzoli G, Ghelardi F, Ligero M, Jonnagaddala J, Hawkins N, Ward R, Wankhede D, Brenner H, Hoffmeister M, Vitellaro M, Salvatore L, Gallois C, Laurent-Puig P, Cremolini C, Overman M, Taieb J, Tougeron D, Andre T, Kather J, Sundar R, Carmona J, Elez E, Koopman M, Pietrantonio F. Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors. Journal For ImmunoTherapy Of Cancer 2025, 13: e010598. PMID: 39929672, PMCID: PMC11815414, DOI: 10.1136/jitc-2024-010598.Peer-Reviewed Original ResearchSpatial predictors of response to chemo-immunotherapy in microsatellite stable metastatic colorectal cancer
Choo J, Zhao J, Lau M, Raimondi A, Yim W, Ranganathan S, Zhu K, Tan C, Chin H, Teo C, Fong K, Tay R, Lee J, Loo L, Manca P, Morano F, Prisciandaro M, Randon G, Damonte C, Micarelli E, Leoni G, Scarselli E, Lonardi S, Cremolini C, Marmorino F, Lim J, Neo Z, Wee F, Chong L, Joseph C, Balachander A, Lim D, Hwang Y, Renia L, Biswas S, Tan D, Yeong J, Sundar R, Pietrantonio F. Spatial predictors of response to chemo-immunotherapy in microsatellite stable metastatic colorectal cancer. Nature Communications 2026 PMID: 42034603, DOI: 10.1038/s41467-026-72204-2.Peer-Reviewed Original Research
2026
Long-term survival outcomes with immune checkpoint inhibition in PD-L1 low or intermediate expressing gastroesophageal adenocarcinoma
Zhao J, Pietrantonio F. Long-term survival outcomes with immune checkpoint inhibition in PD-L1 low or intermediate expressing gastroesophageal adenocarcinoma. Annals Of Oncology 2026, 37: 754-755. PMID: 41887944, DOI: 10.1016/j.annonc.2026.02.016.Commentaries, Editorials and Letters
2025
Checkpoint inhibitor benefit in perioperative gastro-esophageal cancer: A meta-analysis of phase III trials
Zhao J, Yi Ng K, Sundar R, Klempner S. Checkpoint inhibitor benefit in perioperative gastro-esophageal cancer: A meta-analysis of phase III trials. Cancer Treatment Reviews 2025, 140: 103002. PMID: 40779895, DOI: 10.1016/j.ctrv.2025.103002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer
Tay R, Sachdeva M, Ma H, Kim Y, Kook M, Kim H, Cheong J, Hewitt L, Nekolla K, Schmidt G, Yoshikawa T, Oshima T, Arai T, Srivastava S, Teh M, Ong X, Tay S, Sheng T, Zhao J, Tan P, Grabsch H, Sundar R. Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer. Gastric Cancer 2025, 28: 384-396. PMID: 39971854, PMCID: PMC11993452, DOI: 10.1007/s10120-025-01593-y.Peer-Reviewed Original ResearchSpatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
Ma H, Srivastava S, Ho S, Xu C, Lian B, Ong X, Tay S, Sheng T, Lum H, Ghani S, Chu Y, Huang K, Goh Y, Lee M, Hagihara T, Ng C, Tan A, Zhang Y, Ding Z, Zhu F, Ng M, Joseph C, Chen H, Li Z, Zhao J, Rha S, Teh M, Yeong J, Yong W, So J, Sundar R, Tan P. Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution. Cancer Discovery 2025, 15: 767-792. PMID: 39774838, PMCID: PMC11962405, DOI: 10.1158/2159-8290.cd-24-0605.Peer-Reviewed Original Research
2024
PD-L1 expression as a negative predictive biomarker in advanced esophageal squamous-cell cancer treated with chemotherapy alone
Sachdeva M, Zhao J, Zhu K, Yap D, Wong N, Kumarakulasinghe N, Tey J, Sundar R. PD-L1 expression as a negative predictive biomarker in advanced esophageal squamous-cell cancer treated with chemotherapy alone. ESMO Gastrointestinal Oncology 2024, 7: 100109. PMID: 41646473, PMCID: PMC12836587, DOI: 10.1016/j.esmogo.2024.100109.Peer-Reviewed Original Research
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