2006
On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin
Santos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D. On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin. Pflügers Archiv - European Journal Of Physiology 2006, 452: 283. PMID: 16521020, DOI: 10.1007/s00424-005-0037-2.Peer-Reviewed Original Research
2001
Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein
Santos‐Sacchi J, Shen W, Zheng J, Dallos P. Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein. The Journal Of Physiology 2001, 531: 661-666. PMID: 11251048, PMCID: PMC2278494, DOI: 10.1111/j.1469-7793.2001.0661h.x.Peer-Reviewed Original ResearchConceptsMembrane tensionMembrane motor proteinMembrane-bound proteinsHuman embryonic kidney cellsLateral plasma membraneEmbryonic kidney cellsMolecular basisPlasma membraneProtein prestinMotor proteinsConformational changesHigh-resolution analysisPrestin activityPrestinKidney cellsMembrane potential
1998
Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ
Zhao H, Santos-Sacchi J. Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ. The Journal Of General Physiology 1998, 112: 447-455. PMID: 9758863, PMCID: PMC2229429, DOI: 10.1085/jgp.112.4.447.Peer-Reviewed Original ResearchConceptsTurgor pressureInner ear gap junctionsMembrane tensionPositive turgor pressureProtein kinase inhibitorsGap junctionsOsmotic pressure regulationPipette pressureSupporting cellsInner earMicroM HCochlear homeostasisGap junctional conductanceKinase inhibitorsMechanical forcesCell sizeJunctional conductance
1995
Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge
Kakehata S, Santos-Sacchi J. Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge. Biophysical Journal 1995, 68: 2190-2197. PMID: 7612863, PMCID: PMC1282124, DOI: 10.1016/s0006-3495(95)80401-7.Peer-Reviewed Original ResearchConceptsIntracellular turgor pressureCortical cytoskeletal networkIntracellular pressureOuter hair cellsCytoskeletal networkCell motilityMammalian basilar membraneCytoskeletal elementsTurgor pressureOHC motorMembrane tensionCell collapseMechanical vibrationNonlinear capacitanceVoltage-dependent capacitanceHair cell motilityGating chargeHair cellsCell configurationCapacitanceMembrane stressOuter hair cell motilityWhole-cell voltage-clamp configurationMotility