2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian age
2023
Cognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain InjuriesConsciousnessConsciousness DisordersHumansMagnetic Resonance ImagingConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementationPhysician attitudes about disorders of consciousness: Good facts make for good ethics
Fins J. Physician attitudes about disorders of consciousness: Good facts make for good ethics. Developmental Medicine & Child Neurology 2023, 65: 1549-1550. PMID: 37058590, PMCID: PMC10576007, DOI: 10.1111/dmcn.15619.Peer-Reviewed Original ResearchEthics Along the Continuum of Research Involving Persons with Disorders of Consciousness
Lewis A, Young M, Rohaut B, Jox R, Claassen J, Creutzfeldt C, Illes J, Kirschen M, Trevick S, Fins J. Ethics Along the Continuum of Research Involving Persons with Disorders of Consciousness. Neurocritical Care 2023, 39: 565-577. PMID: 36977963, PMCID: PMC11023737, DOI: 10.1007/s12028-023-01708-2.Peer-Reviewed Original ResearchConceptsTranslation of researchDisclosure of resultsDisorders of consciousnessContinuum of researchEthical considerationsNeuropalliative careEthics Working GroupInterpretation of outcomesLegally authorized representativeCommunication of resultsComparison of risksStudy designCarePromote recoveryInvolved personsInclusion of minoritiesExclusion criteriaNeurocritical careWorking GroupPersonsInformal reviewOutcomesAwarenessParticipation rightsData protection
2022
Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
Mainali S, Aiyagari V, Alexander S, Bodien Y, Boerwinkle V, Boly M, Brown E, Brown J, Claassen J, Edlow BL, Fink EL, Fins JJ, Foreman B, Frontera J, Geocadin RG, Giacino J, Gilmore EJ, Gosseries O, Hammond F, Helbok R, Claude Hemphill J, Hirsch K, Kim K, Laureys S, Lewis A, Ling G, Livesay SL, McCredie V, McNett M, Menon D, Molteni E, Olson D, O’Phelan K, Park S, Polizzotto L, Javier Provencio J, Puybasset L, Venkatasubba Rao CP, Robertson C, Rohaut B, Rubin M, Sharshar T, Shutter L, Sampaio Silva G, Smith W, Stevens RD, Thibaut A, Vespa P, Wagner AK, Ziai WC, Zink E, I Suarez J. Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care 2022, 37: 326-350. PMID: 35534661, PMCID: PMC9283342, DOI: 10.1007/s12028-022-01505-3.Peer-Reviewed Original ResearchConsciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State".
Fins J. Consciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State". The Journal Of Law, Medicine & Ethics 2022, 50: 181-183. PMID: 35243988, DOI: 10.1017/jme.2022.22.Peer-Reviewed Original ResearchMeSH KeywordsChildConsciousnessConsciousness DisordersDissent and DisputesHumansPersistent Vegetative StateSocial Justice
2021
The neuroethics of disorders of consciousness: a brief history of evolving ideas
Young M, Bodien Y, Giacino J, Fins J, Truog R, Hochberg L, Edlow B. The neuroethics of disorders of consciousness: a brief history of evolving ideas. Brain 2021, 144: 3291-3310. PMID: 34347037, PMCID: PMC8883802, DOI: 10.1093/brain/awab290.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMulti-Society Task ForceAmerican Congress of Rehabilitation MedicineNational Institute on DisabilityNatural history of recoveryHistory of recoveryAmerican Academy of NeurologyRehabilitation researchRehabilitation medicineTreatment of disorders of consciousnessResponsive careClinical careTaxonomy of disorders of consciousnessAmerican CongressVulnerable populationsIndependent livingProlonged disordersMinimally conscious stateTask ForceAmerican AcademyIncreased awarenessDisability rights perspectiveCareCritically ill patientsBiomedical ethics
2020
Disorders of Consciousness and Disability Law
Fins J, Wright M, Bagenstos S. Disorders of Consciousness and Disability Law. Mayo Clinic Proceedings 2020, 95: 1732-1739. PMID: 32753147, DOI: 10.1016/j.mayocp.2020.02.008.Peer-Reviewed Original ResearchConceptsAmerican Congress of Rehabilitation MedicineNational Institute on DisabilityMulti-Society Task Force ReportMinimally conscious stateUndertreatment of painDisorders of consciousnessRehabilitation of patientsSystematic evidence-based reviewDisability lawAmerican Academy of NeurologyChronic careEvidence-based reviewRehabilitation researchInadequate rehabilitationRehabilitation medicineMedical careNational guidelinesTask Force ReportAmerican CongressNew England JournalPractice guidelinesMedical mainstreamIndependent livingCareInternational disability law
2019
Disorders of Consciousness, Past, Present, and Future
Fins J. Disorders of Consciousness, Past, Present, and Future. Cambridge Quarterly Of Healthcare Ethics 2019, 28: 603-615. PMID: 31405394, DOI: 10.1017/s0963180119000719.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessLegal obligationsPersistent vegetative stateConsciousness literatureNational Institute on DisabilityCognitive motor dissociationMinimally conscious stateCounter-narrativesAmerican Academy of NeurologyVegetative stateMotor dissociationCovert consciousnessObligationsConscious stateDisordersIndependent livingStateAuthor response: Ethical, palliative, and policy considerations in disorders of consciousness.
Fins J, Bernat J. Author response: Ethical, palliative, and policy considerations in disorders of consciousness. Neurology 2019, 92: 974. PMID: 31085728, DOI: 10.1212/wnl.0000000000007519.Peer-Reviewed Original Research
2018
Ethical, Palliative, and Policy Considerations in Disorders of Consciousness
Fins J, Bernat J. Ethical, Palliative, and Policy Considerations in Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2018, 99: 1927-1931. PMID: 30098790, DOI: 10.1016/j.apmr.2018.07.003.Peer-Reviewed Original ResearchMeSH KeywordsConsciousness DisordersHealth PolicyHumansPalliative CarePersistent Vegetative StatePractice Guidelines as TopicRehabilitationConceptsLearning health care systemSystems of careHealth care systemAmerican Academy of Neurology guidelinesGroups of brain-injured patientsMedical decision-makingCognitive-motor dissociationNeuropalliative careAdvance directivesCare systemPractice scopeIncreasing frequency of reportsVegetative stateFrequency of reportingGuideline authorsNeurology guidelinesAmerican AcademyDisorders of consciousnessBrain-injured patientsCareCovert consciousnessGroup of patientsGuidelinesWakefulness syndromePrognostic refinementEthical, palliative, and policy considerations in disorders of consciousness
Fins J, Bernat J. Ethical, palliative, and policy considerations in disorders of consciousness. Neurology 2018, 91: 471-475. PMID: 30089621, DOI: 10.1212/wnl.0000000000005927.Peer-Reviewed Original ResearchConceptsLearning health care systemSystems of careHealth care systemAmerican Academy of Neurology guidelinesGroups of brain-injured patientsMedical decision-makingCognitive-motor dissociationNeuropalliative careAdvance directivesCare systemPractice scopeIncreasing frequency of reportsVegetative stateFrequency of reportingGuideline authorsNeurology guidelinesAmerican AcademyDisorders of consciousnessBrain-injured patientsCareCovert consciousnessGroup of patientsGuidelinesWakefulness syndromePrognostic refinementRights language and disorders of consciousness: a call for advocacy
Fins J, Wright M. Rights language and disorders of consciousness: a call for advocacy. Brain Injury 2018, 32: 670-674. PMID: 29393694, DOI: 10.1080/02699052.2018.1430377.Peer-Reviewed Original ResearchConceptsCivil rightsDisability rights lawsRights of PersonsRights-based argumentsReintegration of peopleRights lawUN ConventionRights languageProvision of rehabilitationRightsSociety itselfCivil societyIntegration of peopleReintegrationSocietyMedical mainstreamCare sectorCare of peopleBrain injuryPersonsLawMaximal integrationConventionBrain injury rehabilitationDisorders of consciousness
2017
Guardianship and Clinical Research Participation: The Case of Wards with Disorders of Consciousness
Wright M, Ulrich M, Fins J. Guardianship and Clinical Research Participation: The Case of Wards with Disorders of Consciousness. Kennedy Institute Of Ethics Journal 2017, 27: 43-70. PMID: 28366903, DOI: 10.1353/ken.2017.0003.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchConsciousness DisordersHumansLegal GuardiansTherapeutic Human ExperimentationUnited StatesConceptsState guardianship lawsGuardianship lawsAppointment of guardiansDecision-making authorityFederal lawGuardian's authorityState lawsClinical research participationDecisional capacityLawPotential medical interventionsDisorders of consciousnessGuardiansResearch participantsBehalfPatient accessAuthorsMedical interventionsGuardianshipStateAppointmentPersonsResearchIssuesParticipants
2016
Giving Voice to Consciousness
Fins J. Giving Voice to Consciousness. Cambridge Quarterly Of Healthcare Ethics 2016, 25: 583-599. PMID: 27634711, DOI: 10.1017/s0963180116000323.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesConsciousness DisordersHuman RightsHumansNeuroimagingNeurosciencesPersistent Vegetative StateBrain death and disorders of consciousness
Schiff N, Fins J. Brain death and disorders of consciousness. Current Biology 2016, 26: r572-r576. PMID: 27404252, DOI: 10.1016/j.cub.2016.02.027.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessBrain-dead patientsBrain deathVegetative stateCognitive motor dissociationScientific knowledgeCognitive functionMinimally conscious stateNon-medical specialistsSocietal contextBrain statesConsciousnessConscious stateMotor dissociationBrainDisordersDead patientsConceptual frameworkLack of sustainabilityHigher levelsFutilityParadoxDistinctionRehabilitation, Education, and the Integration of Individuals with Severe Brain Injury into Civil Society: Towards an Expanded Rights Agenda in Response to New Insights from Translational Neuroethics and Neuroscience.
Wright M, Fins J. Rehabilitation, Education, and the Integration of Individuals with Severe Brain Injury into Civil Society: Towards an Expanded Rights Agenda in Response to New Insights from Translational Neuroethics and Neuroscience. Yale Journal Of Health Policy, Law, And Ethics 2016, 16: 233-87. PMID: 29756752.Peer-Reviewed Original Research
2014
Disorders of consciousness after acquired brain injury: the state of the science
Giacino J, Fins J, Laureys S, Schiff N. Disorders of consciousness after acquired brain injury: the state of the science. Nature Reviews Neurology 2014, 10: 99-114. PMID: 24468878, DOI: 10.1038/nrneurol.2013.279.Peer-Reviewed Original ResearchConceptsApplication of functional neuroimagingFunctional neuroimagingDisorders of consciousnessRegulate arousalDiagnostic bordersConscious awarenessNeural systemsFamily adjustmentTreatment interventionsBehavioral featuresBrain injuryEnhanced outcomesElectrophysiological techniquesArousalNeuroimagingClinical syndromeComplicate patient managementEmpirical evidenceDisordersCovert signs
2013
Disorders of Consciousness and Disordered Care: Families, Caregivers, and Narratives of Necessity
Fins J. Disorders of Consciousness and Disordered Care: Families, Caregivers, and Narratives of Necessity. Archives Of Physical Medicine And Rehabilitation 2013, 94: 1934-1939. PMID: 23770277, DOI: 10.1016/j.apmr.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesCaregiversConsciousness DisordersDecision MakingFamilyHumansPatient Care ManagementPatient Protection and Affordable Care ActUnited StatesConceptsAmerican health care systemAcute care needsSurrogate decision makersHealth care systemDisorders of consciousnessAffordable Care ActDecision-making capacityCare needsSevere disorders of consciousnessCare decisionsOngoing careCare systemReimbursement frameworkCare ActReimbursement strategiesCareMedical necessityCivil rightsMedical infrastructureRehabilitationEthical challengesReimbursementSevere disordersCaregiversPatients
2009
Being Conscious of Their Burden
Fins J. Being Conscious of Their Burden. Annals Of The New York Academy Of Sciences 2009, 1157: 131-147. PMID: 19351362, DOI: 10.1111/j.1749-6632.2009.04473.x.Peer-Reviewed Original Research