2024
Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations
Fins J, Merner A, Wright M, Lázaro-Muñoz G. Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations. The Hastings Center Report 2024, 54: 34-41. PMID: 38390681, PMCID: PMC11022755, DOI: 10.1002/hast.1567.Peer-Reviewed Original ResearchMeSH KeywordsAftercareDeep Brain StimulationDuty to RecontactHumansMoral ObligationsObsessive-Compulsive Disorder
2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchMeSH KeywordsBrain Injuries, TraumaticDeep Brain StimulationFeasibility StudiesHumansQuality of LifeThalamusConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-compliance
2022
Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I
Fins J, Wright M, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I. Cambridge Quarterly Of Healthcare Ethics 2022, 31: 419-443. PMID: 36398511, DOI: 10.1017/s0963180122000226.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticDeep Brain StimulationFamilyHumansQuality of LifeConceptsCentral thalamic deep brain stimulationVoluntary informed consentTraumatic brain injuryDecision-making authorityBrain injuryDeep brain stimulationTherapeutic misconceptionCognitive restorationBrain stimulationAgency of subjectsInformed consentSevere traumatic brain injuryTraumatic brain injury studiesThalamic deep brain stimulationConsentTreatment of traumatic brain injuryEnrollment decisionsBrain injury studiesFamily perspectiveInterpersonal interactionsDecisionCognitive disabilitiesStudy enrollmentReturn to workSocial structureDignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury.
Fins J, Wright M. Dignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury. Perspectives In Biology And Medicine 2022, 65: 307-315. PMID: 35938438, DOI: 10.1353/pbm.2022.0026.Peer-Reviewed Original Research
2020
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?
Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen V, Sheth S, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss J, Kahl K, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang J, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D’Haese P, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia J, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern C, Matthews K, Fins J, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Molecular Psychiatry 2020, 26: 60-65. PMID: 33144712, PMCID: PMC7815503, DOI: 10.1038/s41380-020-00933-x.Peer-Reviewed Original ResearchMeSH KeywordsDeep Brain StimulationHumansMulticenter Studies as TopicObsessive-Compulsive DisorderRandomized Controlled Trials as TopicTreatment OutcomeConceptsObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderRefractory obsessive-compulsive disorderDeep brain stimulationTreatment of psychiatric patientsBrain stimulationProspective international multi-center studyY-BOCSClinical trialsAcceptable risk-benefit ratioPsychiatric patientsBrain areasPsychiatric indicationsRandomized controlled clinical trialLevel I evidenceRisk-benefit ratioClinical cohort studyMulti-center studyInternational multi-center studyLevel II evidenceRandomized controlled trialsSurgical treatmentPsychiatristsConsensus guidelinesCohort study
2017
In Reply: Commentary: Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation
Fins J. In Reply: Commentary: Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation. Neurosurgery 2017, 80: e271-e272. PMID: 28327959, DOI: 10.1093/neuros/nyx039.Peer-Reviewed Original Research
2016
Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research
Fins J. Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research. The AMA Journal Of Ethic 2016, 18: 1182. PMID: 28009244, DOI: 10.1001/journalofethics.2016.18.12.ecas2-1612.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMinimally conscious stateEnd-of-life careConscious stateEnd-of-lifeEthical obligationNeuropalliative careDeep brain stimulationPatientsBrain statesClinicians' ethical obligationsClinical practiceCivil rightsConsciousnessScientific advancesDiagnostic discernmentClinical researchBrain stimulationResearch decisionsDisordersFunctional communicationInvestigate useCareNeuroethicsPainCommentaryDeep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation
Fins J. CommentaryDeep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation. Neurosurgery 2016, 79: 11-13. PMID: 27171326, DOI: 10.1227/neu.0000000000001253.Peer-Reviewed Original Research
2015
Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics
Fins J. Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics. Biomedical Microdevices 2015, 17: 28. PMID: 25681046, DOI: 10.1007/s10544-015-9934-0.Peer-Reviewed Original ResearchMeSH KeywordsBioethicsBrainDeep Brain StimulationHumansNanomedicineNanotechnologyNerve NetNeurotransmitter AgentsPersistent Vegetative StateProstheses and Implants
2014
Beyond Consent in Research
Bell E, Racine E, Chiasson P, Dufourcq-Brana M, Dunn L, Fins J, Ford P, Glannon W, Lipsman N, Macdonald M, Mathews D, McAndrews M. Beyond Consent in Research. Cambridge Quarterly Of Healthcare Ethics 2014, 23: 361-368. PMID: 24865371, DOI: 10.1017/s0963180113000984.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicDecision MakingDeep Brain StimulationEthics, ResearchHumansInformed ConsentMental DisordersPatient SelectionRisk Assessment
2013
Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project
Fins J, Shapiro Z. Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project. Brain Topography 2013, 27: 55-62. PMID: 23749308, DOI: 10.1007/s10548-013-0297-7.Peer-Reviewed Original Research
2012
Challenges to deep brain stimulation: a pragmatic response to ethical, fiscal, and regulatory concerns
Fins J, Dorfman G, Pancrazio J. Challenges to deep brain stimulation: a pragmatic response to ethical, fiscal, and regulatory concerns. Annals Of The New York Academy Of Sciences 2012, 1265: 80-90. PMID: 22823486, PMCID: PMC4030320, DOI: 10.1111/j.1749-6632.2012.06598.x.Peer-Reviewed Original ResearchConceptsIntellectual property exchangePre-market approval processBayh-Dole ActIntellectual property interestsCommon-sense strategiesProperty interestsBayh-DoleRegulatory sphereProperty exchangeManagement of conflictCollege recommendationsApproval processRegulatory concernsPragmatic responseFunded researchPublic-private partnershipInformal mannerExemptionActReformRevisionConflictGovernmentInterestCentral Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamus
2011
A neuromodulation experience registry for deep brain stimulation studies in psychiatric research: Rationale and recommendations for implementation
Synofzik M, Fins J, Schlaepfer T. A neuromodulation experience registry for deep brain stimulation studies in psychiatric research: Rationale and recommendations for implementation. Brain Stimulation 2011, 5: 653-655. PMID: 22100456, DOI: 10.1016/j.brs.2011.10.003.Peer-Reviewed Original ResearchEthical guidance for the management of conflicts of interest for researchers, engineers and clinicians engaged in the development of therapeutic deep brain stimulation
Fins J, Schlaepfer T, Nuttin B, Kubu C, Galert T, Sturm V, Merkel R, Mayberg H. Ethical guidance for the management of conflicts of interest for researchers, engineers and clinicians engaged in the development of therapeutic deep brain stimulation. Journal Of Neural Engineering 2011, 8: 033001. PMID: 21555849, DOI: 10.1088/1741-2560/8/3/033001.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical EngineeringBiomedical ResearchConflict of InterestDeep Brain StimulationHumansInternationalityMedical StaffMisuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder
Fins J, Mayberg H, Nuttin B, Kubu C, Galert T, Sturm V, Stoppenbrink K, Merkel R, Schlaepfer T. Misuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder. Health Affairs 2011, 30: 302-311. PMID: 21289352, DOI: 10.1377/hlthaff.2010.0157.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHumanitarian Device ExemptionSevere obsessive-compulsive disorderUS Food and Drug AdministrationFDA humanitarian device exemptionNeuropsychiatric disordersFood and Drug AdministrationDeep brain stimulationClinical trialsBrain stimulationDrug AdministrationDisordersPatientsFederal regulationsPatient safeguardsProcedure—isExemption
2010
Conflicts of interest in deep brain stimulation research and the ethics of transparency.
Fins J, Schiff N. Conflicts of interest in deep brain stimulation research and the ethics of transparency. The Journal Of Clinical Ethics 2010, 21: 125-32. PMID: 20866018, DOI: 10.1086/jce201021205.Peer-Reviewed Original ResearchDeep Brain Stimulation and the Neuroethics of Responsible Publishing: When One Is Not Enough
Schlaepfer T, Fins J. Deep Brain Stimulation and the Neuroethics of Responsible Publishing: When One Is Not Enough. JAMA 2010, 303: 775-776. PMID: 20179289, DOI: 10.1001/jama.2010.140.Peer-Reviewed Original Research
2009
Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle
Schiff N, Giacino J, Fins J. Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle. JAMA Neurology 2009, 66: 697-702. PMID: 19506129, DOI: 10.1001/archneurol.2009.79.Peer-Reviewed Original Research
2007
Deep brain stimulation and cognition: moving from animal to patient
Schiff N, Fins J. Deep brain stimulation and cognition: moving from animal to patient. Current Opinion In Neurology 2007, 20: 638-642. PMID: 17992082, DOI: 10.1097/wco.0b013e3282f1c6e4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArousalBrainCognition DisordersConsciousnessConsciousness DisordersDeep Brain StimulationDisease Models, AnimalHumansIntralaminar Thalamic NucleiNerve NetConceptsCognitive functionBrain injuryDeep brain stimulationModulate cognitive functionsBrain stimulationCentral thalamic deep brain stimulationImpaired cognitive functionBehavioral improvementBrain electrical stimulationThalamic deep brain stimulationTherapeutic optionsBrainNonprogressive brain injuryArea of researchElectrical stimulationInjuryPatientsStimulationCognitionStudy design