2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian ageBrain injury, medical progress, and the disability paradox: Towards an Americans with Abilities Act
Fins J, Shulman K, Wright M, Shapiro Z. Brain injury, medical progress, and the disability paradox: Towards an Americans with Abilities Act. Neurorehabilitation 2024, 54: 141-147. PMID: 38217618, DOI: 10.3233/nre-230118.Peer-Reviewed Original ResearchConceptsDisability lawLegal protection of patientsInterface of medicineProtection of patientsAmerican jurisprudenceConstitutional protectionLegal protectionLawConstitutive elementsNewfound abilityMedical progressProtectionJurisprudenceLegislationBrain injuryAmericanModerate to severe brain injuryDisabilityParadoxBrain injury professionalsProfessionalsADASevere brain injuryBrain
2023
The Scholarly and Pedagogical Benefits of the Legal Laboratory: Lessons from the Consortium for the Advanced Study of Brain Injury at Yale Law School.
Shapiro Z, Deb C, Lawrence C, Golden A, Wright M, Kraschel K, Fins J. The Scholarly and Pedagogical Benefits of the Legal Laboratory: Lessons from the Consortium for the Advanced Study of Brain Injury at Yale Law School. The Journal Of Law, Medicine & Ethics 2023, 51: 672-683. PMID: 38088597, DOI: 10.1017/jme.2023.126.Peer-Reviewed Original ResearchMinding Brain Injury, Consciousness, and Ethics: Discourse and Deliberations.
Fins J, Giordano J. Minding Brain Injury, Consciousness, and Ethics: Discourse and Deliberations. Kennedy Institute Of Ethics Journal 2023, 33: 227-248. PMID: 38588134, DOI: 10.1353/ken.2023.a917928.Peer-Reviewed Original ResearchA Descriptive Analysis of Access to Assistive Technology in Children With Acquired Brain Injury: The Right to Assistive Devices
Fins J, Knitter J, Mukherjee D, Conti K, Donleavy-Hiller B, Gerber L, Hersh J, Kotorac-Erlbaum R, Milch B, Klein S. A Descriptive Analysis of Access to Assistive Technology in Children With Acquired Brain Injury: The Right to Assistive Devices. Journal Of Head Trauma Rehabilitation 2023, 39: 152-159. PMID: 37492972, PMCID: PMC10811270, DOI: 10.1097/htr.0000000000000876.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesChildDisabled PersonsHumansRetrospective StudiesSelf CareSelf-Help DevicesConceptsSkilled nursing facilityMedical recordsAcquired Brain InjuryHospital outpatient departmentsModerate to severe brain injuryBrain injuryTime to deliveryPotential adverse implicationsAssistive technologyNursing facilitiesSelf-carePediatric cliniciansFostering social integrationImprove mobilityInsurance coverageOutpatient departmentRetrospective chart review of patientsChart review of patientsRetrospective chart reviewAssessment delayInpatient statusVulnerable childrenDescriptive analysisMedical statusLongitudinal trackingCognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain InjuriesConsciousnessConsciousness DisordersHumansMagnetic Resonance ImagingConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementation
2022
Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I
Fins J, Wright M, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I. Cambridge Quarterly Of Healthcare Ethics 2022, 31: 419-443. PMID: 36398511, DOI: 10.1017/s0963180122000226.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticDeep Brain StimulationFamilyHumansQuality of LifeConceptsCentral thalamic deep brain stimulationVoluntary informed consentTraumatic brain injuryDecision-making authorityBrain injuryDeep brain stimulationTherapeutic misconceptionCognitive restorationBrain stimulationAgency of subjectsInformed consentSevere traumatic brain injuryTraumatic brain injury studiesThalamic deep brain stimulationConsentTreatment of traumatic brain injuryEnrollment decisionsBrain injury studiesFamily perspectiveInterpersonal interactionsDecisionCognitive disabilitiesStudy enrollmentReturn to workSocial structureProlonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia
Waldrop G, Safavynia S, Barra M, Agarwal S, Berlin D, Boehme A, Brodie D, Choi J, Doyle K, Fins J, Ganglberger W, Hoffman K, Mittel A, Roh D, Mukerji S, Der Nigoghossian C, Park S, Schenck E, Salazar‐Schicchi J, Shen Q, Sholle E, Velazquez A, Walline M, Westover M, Brown E, Victor J, Edlow B, Schiff N, Claassen J. Prolonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia. Annals Of Neurology 2022, 91: 740-755. PMID: 35254675, PMCID: PMC9082460, DOI: 10.1002/ana.26342.Peer-Reviewed Original ResearchConceptsCessation of mechanical ventilationAssociated with hypoxemiaMedian timeMechanical ventilationAssociated with more severe hypoxemiaDays of hypoxemiaEvidence of structural brain injurySevere coronavirus disease 2019Cox proportional hazards modelsArterial partial pressure of oxygenImpairment of consciousnessSevere COVID-19Survivors of severe COVID-19Proportional hazards modelArterial partial pressureBrain injuryStructural brain injurySevere hypoxemiaCohort studyLife-sustaining therapyEndotracheal intubationHypoxemiaProlonged unconsciousnessPartial pressure of oxygenPatientsDignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury.
Fins J, Wright M. Dignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury. Perspectives In Biology And Medicine 2022, 65: 307-315. PMID: 35938438, DOI: 10.1353/pbm.2022.0026.Peer-Reviewed Original Research
2021
In Pursuit of Agency Ex Machina: Expanding the Map in Severe Brain Injury
Fins J, Wright M, Giacino J, Henderson J, Schiff N. In Pursuit of Agency Ex Machina: Expanding the Map in Severe Brain Injury. AJOB Neuroscience 2021, 12: 200-202. PMID: 33960894, PMCID: PMC8496492, DOI: 10.1080/21507740.2021.1904050.Peer-Reviewed Original Research
2020
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticConnectomeConsciousnessHumansIntensive Care UnitsTreatment OutcomeConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteriaThe Neglect of Persons with Severe Brain Injury in the United States: An International Human Rights Analysis.
Ezer T, Wright M, Fins J. The Neglect of Persons with Severe Brain Injury in the United States: An International Human Rights Analysis. Health And Human Rights 2020, 22: 265-278. PMID: 32669806, PMCID: PMC7348445.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesDisabled PersonsHealth Services AccessibilityHuman RightsHumansQuality of LifeUnited StatesConceptsHuman rights analysisFreedom of expressionBlock to treatmentUnited StatesRights analysisLife of personsExperiences of personsTraumatic incidentsQuality of life of personsPersonsScientific progressNeglectMedical advancesBrain injuryInadequate accessLawViolationStateSignificant medical advancesFreedomEqualityInstitutionalizationUnitsInternationalPolicy
2019
A Narrative of Advocacy, Resilience, and Recovery Following Severe Brain Injury
Fins J. A Narrative of Advocacy, Resilience, and Recovery Following Severe Brain Injury. Journal Of Head Trauma Rehabilitation 2019, 34: 364-365. PMID: 31498234, DOI: 10.1097/htr.0000000000000517.Peer-Reviewed Original ResearchMosaic Decisionmaking and Severe Brain Injury: Adding Another Piece to the Argument
Fins J. Mosaic Decisionmaking and Severe Brain Injury: Adding Another Piece to the Argument. Cambridge Quarterly Of Healthcare Ethics 2019, 28: 737-743. PMID: 31423964, DOI: 10.1017/s0963180119000677.Peer-Reviewed Original Research
2017
Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury
Fins J. Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury. Cambridge Quarterly Of Healthcare Ethics 2017, 27: 163-174. PMID: 28918755, DOI: 10.1017/s0963180117000329.Peer-Reviewed Original ResearchPenfield's ceiling
Adams Z, Fins J. Penfield's ceiling. Neurology 2017, 89: 854-858. PMID: 28827458, DOI: 10.1212/wnl.0000000000004267.Peer-Reviewed Original ResearchMeSH KeywordsArchitectureBrain InjuriesGreeceHistory, 19th CenturyHistory, 20th CenturyHistory, AncientHumansNeurologyPrognosisQuebec
2016
Giving Voice to Consciousness
Fins J. Giving Voice to Consciousness. Cambridge Quarterly Of Healthcare Ethics 2016, 25: 583-599. PMID: 27634711, DOI: 10.1017/s0963180116000323.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesConsciousness DisordersHuman RightsHumansNeuroimagingNeurosciencesPersistent Vegetative StateWhither the “Improvement Standard”? Coverage for Severe Brain Injury after Jimmo v. Sebelius
Fins J, Wright M, Kraft C, Rogers A, Romani M, Godwin S, Ulrich M. Whither the “Improvement Standard”? Coverage for Severe Brain Injury after Jimmo v. Sebelius. The Journal Of Law, Medicine & Ethics 2016, 44: 182-193. PMID: 27256134, DOI: 10.1177/1073110516644209.Peer-Reviewed Original Research
2014
Disorders of consciousness after acquired brain injury: the state of the science
Giacino J, Fins J, Laureys S, Schiff N. Disorders of consciousness after acquired brain injury: the state of the science. Nature Reviews Neurology 2014, 10: 99-114. PMID: 24468878, DOI: 10.1038/nrneurol.2013.279.Peer-Reviewed Original ResearchConceptsApplication of functional neuroimagingFunctional neuroimagingDisorders of consciousnessRegulate arousalDiagnostic bordersConscious awarenessNeural systemsFamily adjustmentTreatment interventionsBehavioral featuresBrain injuryEnhanced outcomesElectrophysiological techniquesArousalNeuroimagingClinical syndromeComplicate patient managementEmpirical evidenceDisordersCovert signs
2013
Surrogate expectations in severe brain injury
Suppes A, Fins J. Surrogate expectations in severe brain injury. Brain Injury 2013, 27: 1141-1147. PMID: 23895513, PMCID: PMC5454804, DOI: 10.3109/02699052.2013.804201.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdvance Care PlanningAdvance DirectivesBrain InjuriesCaregiversChildComaDecision MakingFamilyFemaleGriefHumansIntensive Care UnitsMaleMiddle AgedNew YorkPersistent Vegetative StatePhysician's RoleProfessional-Family RelationsPrognosisProxySeverity of Illness IndexStress, PsychologicalConceptsSource of injuryExpectations of recoveryPsychosocial featuresDecision-making expectationsQuantitative questionnaireImprove treatment of patientsFamily membersPatient recoveryTreatment of patientsPatient diagnosisRelated factorsDOC patientsBrain injuryPatientsImproved treatmentInjuryCurrent diagnosisExpectationsQuestionnaireDiagnosisCliniciansBrainSurveyFactors