2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian age
2022
Consciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State".
Fins J. Consciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State". The Journal Of Law, Medicine & Ethics 2022, 50: 181-183. PMID: 35243988, DOI: 10.1017/jme.2022.22.Peer-Reviewed Original ResearchMeSH KeywordsChildConsciousnessConsciousness DisordersDissent and DisputesHumansPersistent Vegetative StateSocial Justice
2020
Disorders of Consciousness and Disability Law
Fins J, Wright M, Bagenstos S. Disorders of Consciousness and Disability Law. Mayo Clinic Proceedings 2020, 95: 1732-1739. PMID: 32753147, DOI: 10.1016/j.mayocp.2020.02.008.Peer-Reviewed Original ResearchConceptsAmerican Congress of Rehabilitation MedicineNational Institute on DisabilityMulti-Society Task Force ReportMinimally conscious stateUndertreatment of painDisorders of consciousnessRehabilitation of patientsSystematic evidence-based reviewDisability lawAmerican Academy of NeurologyChronic careEvidence-based reviewRehabilitation researchInadequate rehabilitationRehabilitation medicineMedical careNational guidelinesTask Force ReportAmerican CongressNew England JournalPractice guidelinesMedical mainstreamIndependent livingCareInternational disability law
2019
Disorders of Consciousness, Past, Present, and Future
Fins J. Disorders of Consciousness, Past, Present, and Future. Cambridge Quarterly Of Healthcare Ethics 2019, 28: 603-615. PMID: 31405394, DOI: 10.1017/s0963180119000719.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessLegal obligationsPersistent vegetative stateConsciousness literatureNational Institute on DisabilityCognitive motor dissociationMinimally conscious stateCounter-narrativesAmerican Academy of NeurologyVegetative stateMotor dissociationCovert consciousnessObligationsConscious stateDisordersIndependent livingStateWhen No One Notices: Disorders of Consciousness and the Chronic Vegetative State
Fins J. When No One Notices: Disorders of Consciousness and the Chronic Vegetative State. The Hastings Center Report 2019, 49: 14-17. PMID: 31429953, DOI: 10.1002/hast.1030.Peer-Reviewed Original ResearchConceptsNational Institute on DisabilityMulti-Society Task Force ReportDisorders of consciousnessAmerican Academy of NeurologyComprehensive evidence-based reviewEvidence-based reviewRehabilitation researchRehabilitation medicineVegetative stateChronic vegetative stateHealthcare facilitiesTask Force ReportPractice guidelinesIndependent livingPersistent vegetative stateAmerican CollegeAmerican AcademyMisdiagnosis of patientsLevel of consciousnessPermanent vegetative stateForce ReportDiagnostic categoriesPatientsAmericanGuidelinesOnce and Future Clinical Neuroethics: A History of What Was and What Might Be.
Fins J. Once and Future Clinical Neuroethics: A History of What Was and What Might Be. The Journal Of Clinical Ethics 2019, 30: 27-34. PMID: 30896441, DOI: 10.1086/jce2019301027.Peer-Reviewed Original ResearchMeSH KeywordsBioethicsConsciousnessHistory, 20th CenturyHumansNeurosciencesPersistent Vegetative State
2018
Assessment of Covert Consciousness in the Intensive Care Unit
Edlow B, Fins J. Assessment of Covert Consciousness in the Intensive Care Unit. Journal Of Head Trauma Rehabilitation 2018, 33: 424-434. PMID: 30395042, PMCID: PMC6317885, DOI: 10.1097/htr.0000000000000448.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTraumatic brain injuryAcute severe traumatic brain injurySevere traumatic brain injuryIntensive care unitCovert consciousnessEthical challengesIntensive care unit patientsTask-based functional magnetic resonance imagingTask-based fMRILife-sustaining therapyWithdrawal of life-sustaining therapyCare unitEthical frameworkBehavioral assessmentCritically ill patientsEvaluation normsMagnetic resonance imagingConsciousnessBrain injuryGoals of careClinical scenariosIll patientsRecovered consciousnessTreatment decisionsConstructive Disappointment and Disbelief: Building a Career in Neuroethics
Fins J. Constructive Disappointment and Disbelief: Building a Career in Neuroethics. Cambridge Quarterly Of Healthcare Ethics 2018, 27: 544-553. PMID: 30198463, DOI: 10.1017/s0963180118000063.Peer-Reviewed Original ResearchEthical, Palliative, and Policy Considerations in Disorders of Consciousness
Fins J, Bernat J. Ethical, Palliative, and Policy Considerations in Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2018, 99: 1927-1931. PMID: 30098790, DOI: 10.1016/j.apmr.2018.07.003.Peer-Reviewed Original ResearchMeSH KeywordsConsciousness DisordersHealth PolicyHumansPalliative CarePersistent Vegetative StatePractice Guidelines as TopicRehabilitationConceptsLearning health care systemSystems of careHealth care systemAmerican Academy of Neurology guidelinesGroups of brain-injured patientsMedical decision-makingCognitive-motor dissociationNeuropalliative careAdvance directivesCare systemPractice scopeIncreasing frequency of reportsVegetative stateFrequency of reportingGuideline authorsNeurology guidelinesAmerican AcademyDisorders of consciousnessBrain-injured patientsCareCovert consciousnessGroup of patientsGuidelinesWakefulness syndromePrognostic refinement
2017
Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury
Fins J. Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury. Cambridge Quarterly Of Healthcare Ethics 2017, 27: 163-174. PMID: 28918755, DOI: 10.1017/s0963180117000329.Peer-Reviewed Original Research
2016
Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research
Fins J. Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research. The AMA Journal Of Ethic 2016, 18: 1182. PMID: 28009244, DOI: 10.1001/journalofethics.2016.18.12.ecas2-1612.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMinimally conscious stateEnd-of-life careConscious stateEnd-of-lifeEthical obligationNeuropalliative careDeep brain stimulationPatientsBrain statesClinicians' ethical obligationsClinical practiceCivil rightsConsciousnessScientific advancesDiagnostic discernmentClinical researchBrain stimulationResearch decisionsDisordersFunctional communicationInvestigate useCareNeuroethicsPainGiving Voice to Consciousness
Fins J. Giving Voice to Consciousness. Cambridge Quarterly Of Healthcare Ethics 2016, 25: 583-599. PMID: 27634711, DOI: 10.1017/s0963180116000323.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesConsciousness DisordersHuman RightsHumansNeuroimagingNeurosciencesPersistent Vegetative StateThe historical origins of the vegetative state: Received wisdom and the utility of the text
Adams Z, Fins J. The historical origins of the vegetative state: Received wisdom and the utility of the text. Journal Of The History Of The Neurosciences 2016, 26: 140-153. PMID: 27295518, DOI: 10.1080/0964704x.2016.1184074.Peer-Reviewed Original ResearchMeSH KeywordsConsciousnessGreeceHistory, 18th CenturyHistory, 19th CenturyHistory, 20th CenturyHistory, AncientHumansNeurosciencesPersistent Vegetative StatePhilosophyScotlandUnited StatesConceptsPersistent vegetative stateHistorical originsEarly-twentieth centuriesClassical scholarshipOriginal GreekAristotle’s treatisesAristotle’s definitionXavier BichatVegetative stateTheory of MindReception studiesMedical nosologyAristotleReceived wisdomPhrasesBichatAntiquityNineteenthGreekTreatisesCenturyEtymologyClassicsOriginScholarshipWhither the “Improvement Standard”? Coverage for Severe Brain Injury after Jimmo v. Sebelius
Fins J, Wright M, Kraft C, Rogers A, Romani M, Godwin S, Ulrich M. Whither the “Improvement Standard”? Coverage for Severe Brain Injury after Jimmo v. Sebelius. The Journal Of Law, Medicine & Ethics 2016, 44: 182-193. PMID: 27256134, DOI: 10.1177/1073110516644209.Peer-Reviewed Original Research
2015
Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics
Fins J. Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics. Biomedical Microdevices 2015, 17: 28. PMID: 25681046, DOI: 10.1007/s10544-015-9934-0.Peer-Reviewed Original ResearchMeSH KeywordsBioethicsBrainDeep Brain StimulationHumansNanomedicineNanotechnologyNerve NetNeurotransmitter AgentsPersistent Vegetative StateProstheses and Implants
2013
Surrogate expectations in severe brain injury
Suppes A, Fins J. Surrogate expectations in severe brain injury. Brain Injury 2013, 27: 1141-1147. PMID: 23895513, PMCID: PMC5454804, DOI: 10.3109/02699052.2013.804201.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdvance Care PlanningAdvance DirectivesBrain InjuriesCaregiversChildComaDecision MakingFamilyFemaleGriefHumansIntensive Care UnitsMaleMiddle AgedNew YorkPersistent Vegetative StatePhysician's RoleProfessional-Family RelationsPrognosisProxySeverity of Illness IndexStress, PsychologicalConceptsSource of injuryExpectations of recoveryPsychosocial featuresDecision-making expectationsQuantitative questionnaireImprove treatment of patientsFamily membersPatient recoveryTreatment of patientsPatient diagnosisRelated factorsDOC patientsBrain injuryPatientsImproved treatmentInjuryCurrent diagnosisExpectationsQuestionnaireDiagnosisCliniciansBrainSurveyFactorsReanalysis of “Bedside detection of awareness in the vegetative state: a cohort study”
Goldfine A, Bardin J, Noirhomme Q, Fins J, Schiff N, Victor J. Reanalysis of “Bedside detection of awareness in the vegetative state: a cohort study”. The Lancet 2013, 381: 289-291. PMID: 23351802, PMCID: PMC3641526, DOI: 10.1016/s0140-6736(13)60125-7.Peer-Reviewed Original Research
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamusSevere Brain Injury and Organ Solicitation: A Call for Temperance
Fins J. Severe Brain Injury and Organ Solicitation: A Call for Temperance. The AMA Journal Of Ethic 2012, 14: 221. PMID: 23352008, DOI: 10.1001/virtualmentor.2012.14.3.stas1-1203.Peer-Reviewed Original ResearchBrain InjuriesComaHumansPersistent Vegetative StateSocial Control, InformalTissue and Organ ProcurementTreatment Outcome
2011
Neuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics