2022
Prolonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia
Waldrop G, Safavynia S, Barra M, Agarwal S, Berlin D, Boehme A, Brodie D, Choi J, Doyle K, Fins J, Ganglberger W, Hoffman K, Mittel A, Roh D, Mukerji S, Der Nigoghossian C, Park S, Schenck E, Salazar‐Schicchi J, Shen Q, Sholle E, Velazquez A, Walline M, Westover M, Brown E, Victor J, Edlow B, Schiff N, Claassen J. Prolonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia. Annals Of Neurology 2022, 91: 740-755. PMID: 35254675, PMCID: PMC9082460, DOI: 10.1002/ana.26342.Peer-Reviewed Original ResearchConceptsCessation of mechanical ventilationAssociated with hypoxemiaMedian timeMechanical ventilationAssociated with more severe hypoxemiaDays of hypoxemiaEvidence of structural brain injurySevere coronavirus disease 2019Cox proportional hazards modelsArterial partial pressure of oxygenImpairment of consciousnessSevere COVID-19Survivors of severe COVID-19Proportional hazards modelArterial partial pressureBrain injuryStructural brain injurySevere hypoxemiaCohort studyLife-sustaining therapyEndotracheal intubationHypoxemiaProlonged unconsciousnessPartial pressure of oxygenPatients
2011
Neuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics
2010
In the Blink of the Mind's Eye
Fins J, Schiff N. In the Blink of the Mind's Eye. The Hastings Center Report 2010, 40: 21-23. PMID: 20549875, DOI: 10.1353/hcr.0.0257.Peer-Reviewed Original Research
2008
Neuroethics and Neuroimaging: Moving Toward Transparency
Fins J. Neuroethics and Neuroimaging: Moving Toward Transparency. The American Journal Of Bioethics 2008, 8: 46-52. PMID: 18853386, DOI: 10.1080/15265160802334490.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessDiagnostic nosologyNeural mechanismsMinimally conscious stateWorking brainDiagnostic categoriesNeuroimaging findingsTherapeutic agendaDiagnostic refinementNeuroimagingAge of neuroscienceMechanisms of recoveryBrain injuryAssessment ScaleTranslation of research findingsDisordersBrainConscious stateEthical conduct of researchClinical contextConduct of researchResearch findingsFunctional levelEthical conductNosology
2005
Rethinking Disorders of Consciousness: New Research and Its Implications
FINS J. Rethinking Disorders of Consciousness: New Research and Its Implications. The Hastings Center Report 2005, 35: 22-24. PMID: 15957315, DOI: 10.1353/hcr.2005.0020.Peer-Reviewed Original Research
2002
Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
Schiff N, Ribary U, Moreno D, Beattie B, Kronberg E, Blasberg R, Giacino J, McCagg C, Fins J, Llinás R, Plum F. Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain 2002, 125: 1210-1234. PMID: 12023311, DOI: 10.1093/brain/awf131.Peer-Reviewed Original ResearchConceptsPersistent vegetative stateCortical metabolismCerebral metabolismUnique metabolic patternsPersistent vegetative state patientsCerebral regionsResponse to sensory stimulationConscious brain functionGamma-band activityParamedian thalamusPathology reportsFDG-PETAnoxic injuryGlobal metabolic rateCorticothalamic networksMultifocal brain injuriesMetabolic activityMetabolic ratePartial functional integrityPatientsNeuronal islandsEmission tomographyBrain metabolismIsolated brain regionsMetabolic patterns