2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-compliance
2022
Dignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury.
Fins J, Wright M. Dignity of Risk, Reemergent Agency, and the Central Thalamic Stimulation Trial for Moderate to Severe Brain Injury. Perspectives In Biology And Medicine 2022, 65: 307-315. PMID: 35938438, DOI: 10.1353/pbm.2022.0026.Peer-Reviewed Original Research
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamus
2009
Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle
Schiff N, Giacino J, Fins J. Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle. JAMA Neurology 2009, 66: 697-702. PMID: 19506129, DOI: 10.1001/archneurol.2009.79.Peer-Reviewed Original Research
2007
Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff N, Giacino J, Kalmar K, Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448: 600-603. PMID: 17671503, DOI: 10.1038/nature06041.Peer-Reviewed Original Research
2005
The Afterlife of Terri Schiavo
Fins J, Schiff N. The Afterlife of Terri Schiavo. The Hastings Center Report 2005, 35: 8-8. PMID: 16225295, DOI: 10.1353/hcr.2005.0038.Peer-Reviewed Original Research