2024
Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations
Fins J, Merner A, Wright M, Lázaro-Muñoz G. Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations. The Hastings Center Report 2024, 54: 34-41. PMID: 38390681, PMCID: PMC11022755, DOI: 10.1002/hast.1567.Peer-Reviewed Original Research
2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-complianceSubject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury: Part II.
Fins J, Wright M, Shulman K, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury: Part II. Cambridge Quarterly Of Healthcare Ethics 2023, 1-24. PMID: 37850455, DOI: 10.1017/s0963180123000518.Peer-Reviewed Original ResearchFamily perspectiveTraumatic brain injuryOn-going careTrail-Making-TestDecision-making capacitySevere traumatic brain injuryBrain injurySupportive counselingStimulation trialsNarrative responsesPost-trial accessVoluntary informed consentPost-operative interviewsFamily membersSocial reintegrationMarkers of executive functionCognitive functionFamily dynamicsInformed consentPart BDeep brain stimulation trialsInterviewsExecutive functionDevice trialsTrials
2022
Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I
Fins J, Wright M, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I. Cambridge Quarterly Of Healthcare Ethics 2022, 31: 419-443. PMID: 36398511, DOI: 10.1017/s0963180122000226.Peer-Reviewed Original ResearchConceptsCentral thalamic deep brain stimulationVoluntary informed consentTraumatic brain injuryDecision-making authorityBrain injuryDeep brain stimulationTherapeutic misconceptionCognitive restorationBrain stimulationAgency of subjectsInformed consentSevere traumatic brain injuryTraumatic brain injury studiesThalamic deep brain stimulationConsentTreatment of traumatic brain injuryEnrollment decisionsBrain injury studiesFamily perspectiveInterpersonal interactionsDecisionCognitive disabilitiesStudy enrollmentReturn to workSocial structure
2018
Assessment of Covert Consciousness in the Intensive Care Unit
Edlow B, Fins J. Assessment of Covert Consciousness in the Intensive Care Unit. Journal Of Head Trauma Rehabilitation 2018, 33: 424-434. PMID: 30395042, PMCID: PMC6317885, DOI: 10.1097/htr.0000000000000448.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTraumatic brain injuryAcute severe traumatic brain injurySevere traumatic brain injuryIntensive care unitCovert consciousnessEthical challengesIntensive care unit patientsTask-based functional magnetic resonance imagingTask-based fMRILife-sustaining therapyWithdrawal of life-sustaining therapyCare unitEthical frameworkBehavioral assessmentCritically ill patientsEvaluation normsMagnetic resonance imagingConsciousnessBrain injuryGoals of careClinical scenariosIll patientsRecovered consciousnessTreatment decisions
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamus
2009
Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research
Fins J. Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research. 2009, 81-91. DOI: 10.1016/b978-0-12-374248-3.00010-0.Peer-Reviewed Original ResearchFood and Drug AdministrationFood and Drug Administration approvalDeep brain stimulationManagement of chronic painResearch of deep brain stimulationBenefit of neuromodulationTreatment of Parkinson's diseaseBrain stimulationRefractory Parkinson's diseaseChronic painParkinson's diseaseObsessive-compulsive disorderManagement of epilepsyClinical trialsClinical investigationDrug AdministrationEthical issuesPutative treatmentsClinical practiceTraumatic brain injuryClinical applicationMovement disordersEssential tremorTherapeutic deploymentPatients
2007
Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff N, Giacino J, Kalmar K, Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448: 600-603. PMID: 17671503, DOI: 10.1038/nature06041.Peer-Reviewed Original Research
2003
From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
Fins J. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurgery Clinics Of North America 2003, 14: 303-319. PMID: 12856496, DOI: 10.1016/s1042-3680(02)00118-3.Peer-Reviewed Original ResearchConceptsPsychiatric illnessDeep brain stimulationObsessive-compulsive disorderEra of psychosurgerySevere psychiatric illnessTreat psychiatric illnessBrain stimulationTreatment of Parkinson's diseaseModulation of consciousnessTraumatic brain injurySomatic therapiesNeuropsychiatric researchPrefrontal lobotomyBrain injuryCongressional callsPsychosurgeryParkinson's diseaseImplanted deep brain stimulationNeuromodulationIllnessHistory lessonsPsychiatristsPsychiatryLobotomyWidespread condemnation
2000
A proposed ethical framework for interventional cognitive neuroscience: A consideration of deep brain stimulation impaired consciousness
Fins J. A proposed ethical framework for interventional cognitive neuroscience: A consideration of deep brain stimulation impaired consciousness. Neurological Research 2000, 22: 273-278. PMID: 10769820, DOI: 10.1080/01616412.2000.11740670.Peer-Reviewed Original ResearchConceptsCognitive neuroscienceEthical frameworkEvaluation of study designHuman subjects researchTraumatic brain injuryVulnerable study populationEthical obligationParadigm caseDeep brain stimulationScientific inquirySubjects researchSocietal consensusBrain injuryBrain stimulationNeuromodulation techniquesNeuroscienceClinical researchResearch strategyTherapeutic interventionsAttendant developmentObligations