2024
Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations
Fins J, Merner A, Wright M, Lázaro-Muñoz G. Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations. The Hastings Center Report 2024, 54: 34-41. PMID: 38390681, PMCID: PMC11022755, DOI: 10.1002/hast.1567.Peer-Reviewed Original Research
2020
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?
Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen V, Sheth S, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss J, Kahl K, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang J, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D’Haese P, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia J, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern C, Matthews K, Fins J, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Molecular Psychiatry 2020, 26: 60-65. PMID: 33144712, PMCID: PMC7815503, DOI: 10.1038/s41380-020-00933-x.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderRefractory obsessive-compulsive disorderDeep brain stimulationTreatment of psychiatric patientsBrain stimulationProspective international multi-center studyY-BOCSClinical trialsAcceptable risk-benefit ratioPsychiatric patientsBrain areasPsychiatric indicationsRandomized controlled clinical trialLevel I evidenceRisk-benefit ratioClinical cohort studyMulti-center studyInternational multi-center studyLevel II evidenceRandomized controlled trialsSurgical treatmentPsychiatristsConsensus guidelinesCohort study
2014
Devices, Drugs, and Difference: Deep Brain Stimulation and the Advent of Personalized Medicine
Fins J. Devices, Drugs, and Difference: Deep Brain Stimulation and the Advent of Personalized Medicine. 2014, 607-620. DOI: 10.1007/978-94-007-4707-4_33.Peer-Reviewed Original ResearchFDA humanitarian device exemptionIntellectual property exchangeHumanitarian Device ExemptionPharmaceutical regulationDevice regulationProperty exchangeTherapeutic misconceptionInvestigative realmsPatient-centered needsDeep brain stimulationAdvent of personalized medicinePersonalized medicineObsessive-compulsive disorderRegulationBrain stimulationInterdisciplinary expertiseFace barriersExemptionMolecular therapeuticsConflictInvestigation toolScope
2011
Misuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder
Fins J, Mayberg H, Nuttin B, Kubu C, Galert T, Sturm V, Stoppenbrink K, Merkel R, Schlaepfer T. Misuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder. Health Affairs 2011, 30: 302-311. PMID: 21289352, DOI: 10.1377/hlthaff.2010.0157.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHumanitarian Device ExemptionSevere obsessive-compulsive disorderUS Food and Drug AdministrationFDA humanitarian device exemptionNeuropsychiatric disordersFood and Drug AdministrationDeep brain stimulationClinical trialsBrain stimulationDrug AdministrationDisordersPatientsFederal regulationsPatient safeguardsProcedure—isExemption
2009
Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research
Fins J. Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research. 2009, 81-91. DOI: 10.1016/b978-0-12-374248-3.00010-0.Peer-Reviewed Original ResearchFood and Drug AdministrationFood and Drug Administration approvalDeep brain stimulationManagement of chronic painResearch of deep brain stimulationBenefit of neuromodulationTreatment of Parkinson's diseaseBrain stimulationRefractory Parkinson's diseaseChronic painParkinson's diseaseObsessive-compulsive disorderManagement of epilepsyClinical trialsClinical investigationDrug AdministrationEthical issuesPutative treatmentsClinical practiceTraumatic brain injuryClinical applicationMovement disordersEssential tremorTherapeutic deploymentPatients
2003
From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
Fins J. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurgery Clinics Of North America 2003, 14: 303-319. PMID: 12856496, DOI: 10.1016/s1042-3680(02)00118-3.Peer-Reviewed Original ResearchConceptsPsychiatric illnessDeep brain stimulationObsessive-compulsive disorderEra of psychosurgerySevere psychiatric illnessTreat psychiatric illnessBrain stimulationTreatment of Parkinson's diseaseModulation of consciousnessTraumatic brain injurySomatic therapiesNeuropsychiatric researchPrefrontal lobotomyBrain injuryCongressional callsPsychosurgeryParkinson's diseaseImplanted deep brain stimulationNeuromodulationIllnessHistory lessonsPsychiatristsPsychiatryLobotomyWidespread condemnation