Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-complianceSubject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury: Part II.
Fins J, Wright M, Shulman K, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury: Part II. Cambridge Quarterly Of Healthcare Ethics 2023, 1-24. PMID: 37850455, DOI: 10.1017/s0963180123000518.Peer-Reviewed Original ResearchFamily perspectiveTraumatic brain injuryOn-going careTrail-Making-TestDecision-making capacitySevere traumatic brain injuryBrain injurySupportive counselingStimulation trialsNarrative responsesPost-trial accessVoluntary informed consentPost-operative interviewsFamily membersSocial reintegrationMarkers of executive functionCognitive functionFamily dynamicsInformed consentPart BDeep brain stimulation trialsInterviewsExecutive functionDevice trialsTrials