2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian age
2023
Cognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementationPhysician attitudes about disorders of consciousness: Good facts make for good ethics
Fins J. Physician attitudes about disorders of consciousness: Good facts make for good ethics. Developmental Medicine & Child Neurology 2023, 65: 1549-1550. PMID: 37058590, PMCID: PMC10576007, DOI: 10.1111/dmcn.15619.Peer-Reviewed Original ResearchEthics Along the Continuum of Research Involving Persons with Disorders of Consciousness
Lewis A, Young M, Rohaut B, Jox R, Claassen J, Creutzfeldt C, Illes J, Kirschen M, Trevick S, Fins J. Ethics Along the Continuum of Research Involving Persons with Disorders of Consciousness. Neurocritical Care 2023, 39: 565-577. PMID: 36977963, PMCID: PMC11023737, DOI: 10.1007/s12028-023-01708-2.Peer-Reviewed Original ResearchConceptsTranslation of researchDisclosure of resultsDisorders of consciousnessContinuum of researchEthical considerationsNeuropalliative careEthics Working GroupInterpretation of outcomesLegally authorized representativeCommunication of resultsComparison of risksStudy designCarePromote recoveryInvolved personsInclusion of minoritiesExclusion criteriaNeurocritical careWorking GroupPersonsInformal reviewOutcomesAwarenessParticipation rightsData protection
2022
Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics, and Nosological Humility
Fins J. Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics, and Nosological Humility. 2022, 163-175. DOI: 10.1007/978-3-031-04935-4_18.Peer-Reviewed Original ResearchDisorders of consciousnessBrain injuryCognitive motor dissociationStruggle for ConsciousnessRecognition of consciousnessVegetative stateDiagnostic categorizationLimits of knowledgePermanent vegetative stateNosologyPersistent vegetative stateMotor dissociationCovert consciousnessNormative importanceBrainDisordersChronic vegetative stateConsciousnessSocial integrationHumilityEvolving storyNeuroimagingNeuroscienceMindfulnessRightsProceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
Mainali S, Aiyagari V, Alexander S, Bodien Y, Boerwinkle V, Boly M, Brown E, Brown J, Claassen J, Edlow BL, Fink EL, Fins JJ, Foreman B, Frontera J, Geocadin RG, Giacino J, Gilmore EJ, Gosseries O, Hammond F, Helbok R, Claude Hemphill J, Hirsch K, Kim K, Laureys S, Lewis A, Ling G, Livesay SL, McCredie V, McNett M, Menon D, Molteni E, Olson D, O’Phelan K, Park S, Polizzotto L, Javier Provencio J, Puybasset L, Venkatasubba Rao CP, Robertson C, Rohaut B, Rubin M, Sharshar T, Shutter L, Sampaio Silva G, Smith W, Stevens RD, Thibaut A, Vespa P, Wagner AK, Ziai WC, Zink E, I Suarez J. Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care 2022, 37: 326-350. PMID: 35534661, PMCID: PMC9283342, DOI: 10.1007/s12028-022-01505-3.Peer-Reviewed Original ResearchDisorders of Consciousness, Disability Rights, and Triage During the Covid-19 Pandemic
Fins J. Disorders of Consciousness, Disability Rights, and Triage During the Covid-19 Pandemic. 2022, 191-202. DOI: 10.4324/9781003289487-25.Peer-Reviewed Original ResearchEthics and the 2018 Practice Guideline on Disorders of Consciousness
Peterson A, Young M, Fins J. Ethics and the 2018 Practice Guideline on Disorders of Consciousness. Neurology 2022, 98: 712-718. PMID: 35277446, PMCID: PMC9071367, DOI: 10.1212/wnl.0000000000200301.Peer-Reviewed Original ResearchPersonalized medicine and disorders of consciousness
Fins J. Personalized medicine and disorders of consciousness. 2022, 131-140. DOI: 10.1093/oso/9780198863465.003.0010.Peer-Reviewed Original ResearchPersonalized medicineNext-generation personalized medicineDisorders of consciousnessDevelopment of therapeuticsDomain of personalized medicineAccurate diagnostic classificationPathological phenotypesUnique biologyTherapeutic responseMolecular levelIndividual diseasesGuiding treatmentCare of patientsPersonalized therapySide effectsTherapeutic effectMinimally conscious stateBiological characteristicsMolecular biomarkersBiologyDiseaseCharacterize diseaseNeural circuitryPatientsDiagnostic classification
2021
The neuroethics of disorders of consciousness: a brief history of evolving ideas
Young M, Bodien Y, Giacino J, Fins J, Truog R, Hochberg L, Edlow B. The neuroethics of disorders of consciousness: a brief history of evolving ideas. Brain 2021, 144: 3291-3310. PMID: 34347037, PMCID: PMC8883802, DOI: 10.1093/brain/awab290.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMulti-Society Task ForceAmerican Congress of Rehabilitation MedicineNational Institute on DisabilityNatural history of recoveryHistory of recoveryAmerican Academy of NeurologyRehabilitation researchRehabilitation medicineTreatment of disorders of consciousnessResponsive careClinical careTaxonomy of disorders of consciousnessAmerican CongressVulnerable populationsIndependent livingProlonged disordersMinimally conscious stateTask ForceAmerican AcademyIncreased awarenessDisability rights perspectiveCareCritically ill patientsBiomedical ethicsEmpiricism and Rights Justify the Allocation of Health Care Resources to Persons with Disorders of Consciousness
Giacino J, Bodien Y, Zuckerman D, Henderson J, Schiff N, Fins J. Empiricism and Rights Justify the Allocation of Health Care Resources to Persons with Disorders of Consciousness. AJOB Neuroscience 2021, 12: 169-171. PMID: 33960891, DOI: 10.1080/21507740.2021.1904055.Peer-Reviewed Original ResearchConceptsAllocation of health care resourcesHealth care resourcesCare resourcesDisorders of consciousnessDisorders of Consciousness, Disability Rights and Triage During the COVID-19 Pandemic
Fins J. Disorders of Consciousness, Disability Rights and Triage During the COVID-19 Pandemic. The Journal Of Philosophy Of Disability 2021, 1: 211-229. DOI: 10.5840/jpd20218174.Peer-Reviewed Original ResearchNew York State Task Force on LifeStruggle for ConsciousnessVentilator allocation guidelinesDisorders of consciousnessTask ForceNot consciousnessEthical integritySpring surgeAllocation guidelinesCOVID-19 pandemicClinical ethicistsAuthorsNew YorkCOVID-19LawBrain injuryConsciousnessDisordersEthicistsNewPeopleMotor outputEthics
2020
Disorders of Consciousness and Disability Law
Fins J, Wright M, Bagenstos S. Disorders of Consciousness and Disability Law. Mayo Clinic Proceedings 2020, 95: 1732-1739. PMID: 32753147, DOI: 10.1016/j.mayocp.2020.02.008.Peer-Reviewed Original ResearchConceptsAmerican Congress of Rehabilitation MedicineNational Institute on DisabilityMulti-Society Task Force ReportMinimally conscious stateUndertreatment of painDisorders of consciousnessRehabilitation of patientsSystematic evidence-based reviewDisability lawAmerican Academy of NeurologyChronic careEvidence-based reviewRehabilitation researchInadequate rehabilitationRehabilitation medicineMedical careNational guidelinesTask Force ReportAmerican CongressNew England JournalPractice guidelinesMedical mainstreamIndependent livingCareInternational disability law
2019
Disorders of Consciousness, Past, Present, and Future
Fins J. Disorders of Consciousness, Past, Present, and Future. Cambridge Quarterly Of Healthcare Ethics 2019, 28: 603-615. PMID: 31405394, DOI: 10.1017/s0963180119000719.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessLegal obligationsPersistent vegetative stateConsciousness literatureNational Institute on DisabilityCognitive motor dissociationMinimally conscious stateCounter-narrativesAmerican Academy of NeurologyVegetative stateMotor dissociationCovert consciousnessObligationsConscious stateDisordersIndependent livingStateDisorders of Consciousness in Clinical Practice
Fins J. Disorders of Consciousness in Clinical Practice. 2019, 449-478. DOI: 10.1093/med/9780190208875.003.0011.Peer-Reviewed Original ResearchEnd-of-life careEnd-of-lifeLong-term careImpaired decision-making capacityDisorders of consciousnessClinical practiceDecision-making capacityAncillary care obligationsVulnerable populationsProfessional obligationsCareMinimally conscious stateNeuroimaging assessmentsIntensive careCare obligationsDiagnostic classificationBrain injuryCommunication strategiesCovert consciousnessClinicInitial presentationConscious stateEthical implicationsPatientsRehabilitationWhen No One Notices: Disorders of Consciousness and the Chronic Vegetative State
Fins J. When No One Notices: Disorders of Consciousness and the Chronic Vegetative State. The Hastings Center Report 2019, 49: 14-17. PMID: 31429953, DOI: 10.1002/hast.1030.Peer-Reviewed Original ResearchConceptsNational Institute on DisabilityMulti-Society Task Force ReportDisorders of consciousnessAmerican Academy of NeurologyComprehensive evidence-based reviewEvidence-based reviewRehabilitation researchRehabilitation medicineVegetative stateChronic vegetative stateHealthcare facilitiesTask Force ReportPractice guidelinesIndependent livingPersistent vegetative stateAmerican CollegeAmerican AcademyMisdiagnosis of patientsLevel of consciousnessPermanent vegetative stateForce ReportDiagnostic categoriesPatientsAmericanGuidelinesOnce and Future Clinical Neuroethics: A History of What Was and What Might Be.
Fins J. Once and Future Clinical Neuroethics: A History of What Was and What Might Be. The Journal Of Clinical Ethics 2019, 30: 27-34. PMID: 30896441, DOI: 10.1086/jce2019301027.Peer-Reviewed Original Research
2018
Ethical, Palliative, and Policy Considerations in Disorders of Consciousness
Fins J, Bernat J. Ethical, Palliative, and Policy Considerations in Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2018, 99: 1927-1931. PMID: 30098790, DOI: 10.1016/j.apmr.2018.07.003.Peer-Reviewed Original ResearchConceptsLearning health care systemSystems of careHealth care systemAmerican Academy of Neurology guidelinesGroups of brain-injured patientsMedical decision-makingCognitive-motor dissociationNeuropalliative careAdvance directivesCare systemPractice scopeIncreasing frequency of reportsVegetative stateFrequency of reportingGuideline authorsNeurology guidelinesAmerican AcademyDisorders of consciousnessBrain-injured patientsCareCovert consciousnessGroup of patientsGuidelinesWakefulness syndromePrognostic refinementEthical, palliative, and policy considerations in disorders of consciousness
Fins J, Bernat J. Ethical, palliative, and policy considerations in disorders of consciousness. Neurology 2018, 91: 471-475. PMID: 30089621, DOI: 10.1212/wnl.0000000000005927.Peer-Reviewed Original ResearchConceptsLearning health care systemSystems of careHealth care systemAmerican Academy of Neurology guidelinesGroups of brain-injured patientsMedical decision-makingCognitive-motor dissociationNeuropalliative careAdvance directivesCare systemPractice scopeIncreasing frequency of reportsVegetative stateFrequency of reportingGuideline authorsNeurology guidelinesAmerican AcademyDisorders of consciousnessBrain-injured patientsCareCovert consciousnessGroup of patientsGuidelinesWakefulness syndromePrognostic refinementRights language and disorders of consciousness: a call for advocacy
Fins J, Wright M. Rights language and disorders of consciousness: a call for advocacy. Brain Injury 2018, 32: 670-674. PMID: 29393694, DOI: 10.1080/02699052.2018.1430377.Peer-Reviewed Original ResearchConceptsCivil rightsDisability rights lawsRights of PersonsRights-based argumentsReintegration of peopleRights lawUN ConventionRights languageProvision of rehabilitationRightsSociety itselfCivil societyIntegration of peopleReintegrationSocietyMedical mainstreamCare sectorCare of peopleBrain injuryPersonsLawMaximal integrationConventionBrain injury rehabilitationDisorders of consciousness