2024
Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations
Fins J, Merner A, Wright M, Lázaro-Muñoz G. Identity Theft, Deep Brain Stimulation, and the Primacy of Post‐trial Obligations. The Hastings Center Report 2024, 54: 34-41. PMID: 38390681, PMCID: PMC11022755, DOI: 10.1002/hast.1567.Peer-Reviewed Original Research
2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-compliance
2022
Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I
Fins J, Wright M, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I. Cambridge Quarterly Of Healthcare Ethics 2022, 31: 419-443. PMID: 36398511, DOI: 10.1017/s0963180122000226.Peer-Reviewed Original ResearchConceptsCentral thalamic deep brain stimulationVoluntary informed consentTraumatic brain injuryDecision-making authorityBrain injuryDeep brain stimulationTherapeutic misconceptionCognitive restorationBrain stimulationAgency of subjectsInformed consentSevere traumatic brain injuryTraumatic brain injury studiesThalamic deep brain stimulationConsentTreatment of traumatic brain injuryEnrollment decisionsBrain injury studiesFamily perspectiveInterpersonal interactionsDecisionCognitive disabilitiesStudy enrollmentReturn to workSocial structure
2020
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?
Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen V, Sheth S, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss J, Kahl K, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang J, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D’Haese P, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia J, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern C, Matthews K, Fins J, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Molecular Psychiatry 2020, 26: 60-65. PMID: 33144712, PMCID: PMC7815503, DOI: 10.1038/s41380-020-00933-x.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderRefractory obsessive-compulsive disorderDeep brain stimulationTreatment of psychiatric patientsBrain stimulationProspective international multi-center studyY-BOCSClinical trialsAcceptable risk-benefit ratioPsychiatric patientsBrain areasPsychiatric indicationsRandomized controlled clinical trialLevel I evidenceRisk-benefit ratioClinical cohort studyMulti-center studyInternational multi-center studyLevel II evidenceRandomized controlled trialsSurgical treatmentPsychiatristsConsensus guidelinesCohort study
2017
In Reply: Commentary: Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation
Fins J. In Reply: Commentary: Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation. Neurosurgery 2017, 80: e271-e272. PMID: 28327959, DOI: 10.1093/neuros/nyx039.Peer-Reviewed Original Research
2016
Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research
Fins J. Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research. The AMA Journal Of Ethic 2016, 18: 1182. PMID: 28009244, DOI: 10.1001/journalofethics.2016.18.12.ecas2-1612.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMinimally conscious stateEnd-of-life careConscious stateEnd-of-lifeEthical obligationNeuropalliative careDeep brain stimulationPatientsBrain statesClinicians' ethical obligationsClinical practiceCivil rightsConsciousnessScientific advancesDiagnostic discernmentClinical researchBrain stimulationResearch decisionsDisordersFunctional communicationInvestigate useCareNeuroethicsPainCommentaryDeep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation
Fins J. CommentaryDeep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation. Neurosurgery 2016, 79: 11-13. PMID: 27171326, DOI: 10.1227/neu.0000000000001253.Peer-Reviewed Original ResearchConceptsPsychiatric deep-brain stimulationSustained deliberationsBrain stimulationDeep brain stimulationEthicsDeliberationClinical innovation
2015
Ethics of neuromodulation in psychiatry
Fins J, Pohl B. Ethics of neuromodulation in psychiatry. 2015, 15-26. DOI: 10.1002/9781118801086.ch2.Peer-Reviewed Original ResearchSevere psychiatric illnessHealth care systemNeuropsychiatric conditionsPsychiatric illnessPervasive stigmaMental illnessCare systemDeep brain stimulationBrain stimulationClinical ethicsMoral dilemmasDerivative questionsIllnessEthicsDevice regulationNeuromodulationTranslational researchClinical needPsychiatryStigmaHealthBrainInterventionRights Come to Mind
Fins J. Rights Come to Mind. 2015 DOI: 10.1017/cbo9781139051279.Peer-Reviewed Original Research
2014
Devices, Drugs, and Difference: Deep Brain Stimulation and the Advent of Personalized Medicine
Fins J. Devices, Drugs, and Difference: Deep Brain Stimulation and the Advent of Personalized Medicine. 2014, 607-620. DOI: 10.1007/978-94-007-4707-4_33.Peer-Reviewed Original ResearchFDA humanitarian device exemptionIntellectual property exchangeHumanitarian Device ExemptionPharmaceutical regulationDevice regulationProperty exchangeTherapeutic misconceptionInvestigative realmsPatient-centered needsDeep brain stimulationAdvent of personalized medicinePersonalized medicineObsessive-compulsive disorderRegulationBrain stimulationInterdisciplinary expertiseFace barriersExemptionMolecular therapeuticsConflictInvestigation toolScope
2013
Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project
Fins J, Shapiro Z. Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project. Brain Topography 2013, 27: 55-62. PMID: 23749308, DOI: 10.1007/s10548-013-0297-7.Peer-Reviewed Original Research
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamusDeep Brain Stimulation as a Probative Biology: Scientific Inquiry and the Mosaic Device
Fins J. Deep Brain Stimulation as a Probative Biology: Scientific Inquiry and the Mosaic Device. AJOB Neuroscience 2012, 3: 4-8. DOI: 10.1080/21507740.2011.633961.Peer-Reviewed Original ResearchHow Happy Is Too Happy? Euphoria, Neuroethics, and Deep Brain Stimulation of the Nucleus Accumbens
Synofzik M, Schlaepfer T, Fins J. How Happy Is Too Happy? Euphoria, Neuroethics, and Deep Brain Stimulation of the Nucleus Accumbens. AJOB Neuroscience 2012, 3: 30-36. DOI: 10.1080/21507740.2011.635633.Peer-Reviewed Original ResearchNA DBSDeep brain stimulationBrain stimulationIntrinsic objectionsNeuropsychiatric interventionsMaladaptive onesManic stateMotivational stateButton pressMood statesEnhancing affective statesInduce euphoriaAffective statesPsychiatric diseasesSystematic ethical analysisCase vignettesRisk of severe harmExtrinsic argumentsEthical analysisEthical questionsHappinessPersonsEuphoriaIntervention costsContext-dependent
2011
Misuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder
Fins J, Mayberg H, Nuttin B, Kubu C, Galert T, Sturm V, Stoppenbrink K, Merkel R, Schlaepfer T. Misuse Of The FDA’s Humanitarian Device Exemption In Deep Brain Stimulation For Obsessive-Compulsive Disorder. Health Affairs 2011, 30: 302-311. PMID: 21289352, DOI: 10.1377/hlthaff.2010.0157.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHumanitarian Device ExemptionSevere obsessive-compulsive disorderUS Food and Drug AdministrationFDA humanitarian device exemptionNeuropsychiatric disordersFood and Drug AdministrationDeep brain stimulationClinical trialsBrain stimulationDrug AdministrationDisordersPatientsFederal regulationsPatient safeguardsProcedure—isExemption
2009
Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research
Fins J. Chapter 9 Deep Brain Stimulation Ethical Issues in Clinical Practice and Neurosurgical Research. 2009, 81-91. DOI: 10.1016/b978-0-12-374248-3.00010-0.Peer-Reviewed Original ResearchFood and Drug AdministrationFood and Drug Administration approvalDeep brain stimulationManagement of chronic painResearch of deep brain stimulationBenefit of neuromodulationTreatment of Parkinson's diseaseBrain stimulationRefractory Parkinson's diseaseChronic painParkinson's diseaseObsessive-compulsive disorderManagement of epilepsyClinical trialsClinical investigationDrug AdministrationEthical issuesPutative treatmentsClinical practiceTraumatic brain injuryClinical applicationMovement disordersEssential tremorTherapeutic deploymentPatients
2008
Schiff et al. reply
Schiff N, Giacino J, Kalmar K, D.Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, Biondi T, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Schiff et al. reply. Nature 2008, 452: e1-e2. DOI: 10.1038/nature06575.Peer-Reviewed Original Research
2007
Deep brain stimulation and cognition: moving from animal to patient
Schiff N, Fins J. Deep brain stimulation and cognition: moving from animal to patient. Current Opinion In Neurology 2007, 20: 638-642. PMID: 17992082, DOI: 10.1097/wco.0b013e3282f1c6e4.Peer-Reviewed Original ResearchConceptsCognitive functionBrain injuryDeep brain stimulationModulate cognitive functionsBrain stimulationCentral thalamic deep brain stimulationImpaired cognitive functionBehavioral improvementBrain electrical stimulationThalamic deep brain stimulationTherapeutic optionsBrainNonprogressive brain injuryArea of researchElectrical stimulationInjuryPatientsStimulationCognitionStudy designBehavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff N, Giacino J, Kalmar K, Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448: 600-603. PMID: 17671503, DOI: 10.1038/nature06041.Peer-Reviewed Original Research
2004
Protecting human subjects in brain research: a pragmatic perspective
Miller F, Fins J. Protecting human subjects in brain research: a pragmatic perspective. 2004, 123-140. DOI: 10.1093/acprof:oso/9780198567219.003.0009.Peer-Reviewed Original ResearchAmerican philosophical pragmatismEthical judgmentsMoral principlesMoral normsPhilosophical pragmatismResearch ethicsAbsolute ruleEthical considerationsRelevant considerationsPragmatic perspectiveBrain researchTrials of pharmacological treatmentsPlacebo-controlled trialDeep brain stimulationBrain disordersPharmacological treatmentEthicsPragmaticsHuman subjectsJudgmentDisordersBrainConsiderationsComplex situationsNeurological disorders