2022
Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder
Deak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J, Muralidhar S, Moser J, Deen J, Gaziano J, Beckham J, Chang K, Tsao P, Luoh S, Casas J, Churby L, Whitbourne S, Brewer J, Brophy M, Selva L, Shayan S, Cho K, Pyarajan S, DuVall S, Connor T, Argyres D, Aslan M, Stephens B, Concato J, Gelernter J, Gleason T, Huang G, Koenen K, Marx C, Radhakrishnan K, Schork N, Stein M, Zhao H, Kaufman J, Nunez Y, Pietrzak R, Beck D, Cissell S, Crutchfield P, Lance W, Cheung K, Li Y, Sun N, Chen Q, Rajeevan N, Sayward F, Gagnon D, Harrington K, Quaden R, O'Leary T, Ramoni R. Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. JAMA Network Open 2022, 5: e2238880. PMID: 36301540, PMCID: PMC9614582, DOI: 10.1001/jamanetworkopen.2022.38880.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlcohol DrinkingAlcoholismFemaleGenome-Wide Association StudyHumansMaleVeteransWhite PeopleConceptsGenome-wide association studiesGenome-wide significant lociGenomic structural equation modelingSignificant lociAlcohol traitsAssociation studiesAfrican ancestry participantsGenome-wide investigationAncestry-specific genome-wide association studiesGenetic correlationsPsychiatric traitsLinkage disequilibrium score regressionGenetic associationStrong genetic correlationSingle nucleotide variantsGenetic architectureGenetic association studiesGenetic lociTop associationsNegative rgEuropean ancestry participantsNucleotide variantsFunctional variantsScore regressionTraits
2021
Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood
Deak JD, Clark DA, Liu M, Schaefer JD, Jang SK, Durbin CE, Iacono WG, McGue M, Vrieze S, Hicks BM. Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood. Addiction 2021, 117: 1117-1127. PMID: 34590376, PMCID: PMC8931861, DOI: 10.1111/add.15697.Peer-Reviewed Original Research
2019
Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
Deak J, Gizer I, Otto J, Bizon C, Wilhelmsen K. Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. Journal Of Studies On Alcohol And Drugs 2019, 80: 585-593. PMID: 31790348, PMCID: PMC6900988, DOI: 10.15288/jsad.2019.80.585.Peer-Reviewed Original ResearchConceptsVariant associationsCommon variant associationsRare variant association testsRare variant signalsGene-based analysisRare variant associationsMolecular genetic studiesSingle variant analysisIntergenic regionRare variationAlcohol use disorderTop associationsSequencing dataVariant contributionsGenetic studiesAlcoholism (COGA) sampleGenetic sequencing dataReceptor geneUse disordersVariant signalsGene variationTypes of variationConfer riskStrong associationSignificant associationPolygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample
Miller A, Gizer I, Fleming Iii W, Otto J, Deak J, Martins J, Bartholow B. Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample. Psychiatry Research 2019, 279: 47-54. PMID: 31299563, PMCID: PMC6713597, DOI: 10.1016/j.psychres.2019.06.025.Peer-Reviewed Original Research
2018
Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity
Edwards A, Deak J, Gizer I, Lai D, Chatzinakos C, Wilhelmsen K, Lindsay J, Heron J, Hickman M, Webb B, Bacanu S, Foroud T, Kendler K, Dick D, Schuckit M. Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clinical And Experimental Research 2018, 42: 2349-2359. PMID: 30276832, PMCID: PMC6286211, DOI: 10.1111/acer.13896.Peer-Reviewed Original ResearchConceptsCore clock genesClock genesTissue-specific expression dataPopulation-based genome-wide association studiesGenome-wide association studiesGenome-wide significanceGene identification effortsSignificant genetic correlationsMolecular genetic studiesHormone signalingSingle nucleotide polymorphismsIndividual lociGenetic analysisAssociation studiesGenetic studiesExpression dataGenesGenetic componentGenetic correlationsNucleotide polymorphismsHeritabilityAlcohol sensitivityGenetic factorsLow initial sensitivityGenetic influences
2017
A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use
Otto J, Gizer I, Deak J, Fleming K, Bartholow B. A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clinical And Experimental Research 2017, 41: 929-938. PMID: 28273335, PMCID: PMC5404990, DOI: 10.1111/acer.13369.Peer-Reviewed Original ResearchConceptsBiphasic Alcohol Effects ScaleAlcohol useAlcohol use phenotypesSubjective responsesΜ-opioid receptor geneConsistent significant associationsEffects of alcoholHeroin dependenceSignificant associationPast monthEffects ScaleFunctional polymorphismsAlcohol challengeObserved associationsLow levels