2021
Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases
Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.Peer-Reviewed Original ResearchConceptsDevelopmental timingHistone modificationsPotential molecular mechanismsEpigenetic paradigmEpigenetic reprogrammingGenetic reprogrammingDevelopmental programDNA methylationMolecular mechanismsMolecular programmingReprogrammingEarly originsGenesLatest insightsNew insightsOmicsMethylationMicroRNAsHomeostasisLife-long consequencesInsightsTranslational approachRespiratory mucosaRespiratory diseaseCurrent evidence
2018
Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life
Nino C, Perez G, Isaza N, Gutierrez M, Gomez J, Nino G. Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2018, 8: 5526. PMID: 29615635, PMCID: PMC5882800, DOI: 10.1038/s41598-018-23063-5.Peer-Reviewed Original ResearchConceptsX-linked genesDNA methylation signaturesDifferential methylationMethylation signaturesGenome-wide DNA methylationProtein coding transcriptsX chromosome dosageX-chromosome methylationEpigenomic marksMethylation patternsX chromosomeDNA methylationCpG sitesGenomic signaturesX-inactivationGenetic componentCoding transcriptsGenesMethylation signalsAirways of infantsInfants aged 1Independent populationsRespiratory phenotypeAirway expressionIndividual's sex