2020
Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry
Pottackal J, Singer JH, Demb JB. Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry. Frontiers In Cellular Neuroscience 2020, 14: 604163. PMID: 33324168, PMCID: PMC7726240, DOI: 10.3389/fncel.2020.604163.Peer-Reviewed Original ResearchDirection-selective ganglion cellsStarburst amacrine cellsFast cholinergic transmissionGABAergic inhibitionCholinergic transmissionGABAergic transmissionCholinergic excitationPostsynaptic currentsSynaptic mechanismsConventional synaptic transmissionReceptoral mechanismsReceptor blockadeAmacrine cellsGanglion cellsRetinal circuitryParacrine natureSynaptic transmissionConventional synapsesMammalian retinaMouse retinaParacrine transmissionParacrine modeDirection selectivityDistinct temporal propertiesReceptor kinetics
2011
A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast
Jarsky T, Cembrowski M, Logan SM, Kath WL, Riecke H, Demb JB, Singer JH. A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast. Journal Of Neuroscience 2011, 31: 11003-11015. PMID: 21795549, PMCID: PMC3152984, DOI: 10.1523/jneurosci.2631-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmacrine CellsAnimalsBiophysical PhenomenaBiophysicsCalciumContrast SensitivityElectric StimulationExcitatory Postsynaptic PotentialsFemaleIn Vitro TechniquesLightingMaleMiceMice, Inbred C57BLModels, NeurologicalNumerical Analysis, Computer-AssistedPatch-Clamp TechniquesPhotic StimulationPresynaptic TerminalsRetinaRetinal Bipolar CellsSynaptic TransmissionConceptsSynaptic mechanismsSynaptic transmissionBipolar cell synaptic transmissionMouse retinal slice preparationVesicle depletionCommon synaptic mechanismsPrimary sensory circuitsUse-dependent regulationAII amacrine cellsContrast adaptationRetinal slice preparationBipolar cell synapsesCell synaptic transmissionRetinal neural circuitWhole-cell recordingsRetinal bipolar cellsPhasic transmissionTonic transmissionAmacrine cellsSlice preparationCell synapsesBipolar cellsSame cellular mechanismsSensory circuitsNeural circuits