Jimin Wang, PhD
Research ScientistCards
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Research
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2026
Dual site targeting of the bacterial 70S ribosome by tetracyclines
Devarkar S, Lomakin I, Wang J, Grada A, Bunick C. Dual site targeting of the bacterial 70S ribosome by tetracyclines. Nature Communications 2026, 17: 4452. PMID: 42156748, PMCID: PMC13186991, DOI: 10.1038/s41467-026-72788-9.Peer-Reviewed Original ResearchModel-dependent and model-independent visualization of hydrogen atoms in high-resolution cryoEM maps
Wang J. Model-dependent and model-independent visualization of hydrogen atoms in high-resolution cryoEM maps. Acta Crystallographica Section D, Structural Biology 2026, 82: 533-549. PMID: 41954135, DOI: 10.1107/s2059798326002512.Peer-Reviewed Original ResearchComputational Evolution of Anti-PD‑1 Antibodies Induces Structural Refolding for High-Affinity Interactions
Shi Y, Kim Y, Liu P, Wang J, Tang S, Batista V. Computational Evolution of Anti-PD‑1 Antibodies Induces Structural Refolding for High-Affinity Interactions. Biochemistry 2026, 65: 517-520. PMID: 41671420, DOI: 10.1021/acs.biochem.5c00574.Peer-Reviewed Original Research
2025
Visualizing the translation landscape in human cells at high resolution
Zheng W, Zhang Y, Wang J, Wang S, Chai P, Bailey E, Zhu C, Guo W, Devarkar S, Wu S, Lin J, Zhang K, Liu J, Lomakin I, Xiong Y. Visualizing the translation landscape in human cells at high resolution. Nature Communications 2025, 16: 10757. PMID: 41315256, PMCID: PMC12663405, DOI: 10.1038/s41467-025-65795-9.Peer-Reviewed Original ResearchAtomistic modulation of MIF‐2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen
Widjaja V, D'Orazio S, Das P, Rajendran D, Takada X, Shi Y, Varghese I, Lam Y, DaSilva N, Wang J, Batista V, Bhandari V, Lisi G. Atomistic modulation of MIF‐2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen. Protein Science 2025, 34: e70344. PMID: 41099614, PMCID: PMC12529878, DOI: 10.1002/pro.70344.Peer-Reviewed Original ResearchStructural Basis for Differential Jak2 and Jak3 Kinase Selectivity of Ruxolitinib and Delgocitinib
Wang J, Bunick C. Structural Basis for Differential Jak2 and Jak3 Kinase Selectivity of Ruxolitinib and Delgocitinib. Journal Of Investigative Dermatology 2025, 146: 287-290. PMID: 40825469, DOI: 10.1016/j.jid.2025.08.004.Peer-Reviewed Original ResearchStructural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses.
Issa N, Wang J, Hanly A, Ho M, Obagi S, Damiani G, Del Rosso J, Kang Y, Bunick C. Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses. The Journal Of Clinical And Aesthetic Dermatology 2025, 18: 18-21. PMID: 40778010, PMCID: PMC12327561.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA Triple-Action Inhibitory Mechanism of Allosteric TYK2-Specific Inhibitors
Wang J, Lomakin I, Batista V, Bunick C. A Triple-Action Inhibitory Mechanism of Allosteric TYK2-Specific Inhibitors. Journal Of Investigative Dermatology 2025, 145: 3158-3173. PMID: 40378946, DOI: 10.1016/j.jid.2025.04.025.Peer-Reviewed Original ResearchMechanistic insight into O=O bond formation upon model‐independent visualization of the coordination geometry and ligand composition of Mn4Ca cofactor in dark‐adapted photosystem II structures
Wang J. Mechanistic insight into O=O bond formation upon model‐independent visualization of the coordination geometry and ligand composition of Mn4Ca cofactor in dark‐adapted photosystem II structures. Acta Crystallographica Section D, Structural Biology 2025, 81: 291-309. PMID: 40349162, DOI: 10.1107/s2059798325003699.Peer-Reviewed Original ResearchPDE4 Inhibitors: Bridging Molecular Insights With Clinical Impact.
Issa N, Obagi S, Damiani G, Wang J, Bunick C. PDE4 Inhibitors: Bridging Molecular Insights With Clinical Impact. Journal Of Drugs In Dermatology 2025, 24: 631-633. PMID: 40465498, DOI: 10.36849/jdd.9089.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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