Jeff Jiapeng Ruan, PhD
Associate Research Scientist in Medicine (Digestive Diseases)Cards
About
Research
Publications
2025
Refining Mouse Models of Gaucher Disease: Advancing Mechanistic Insights, Biomarker Discovery, and Therapeutic Strategies
Fattahi N, Ruan J, Belinsky G, Xing S, Mistry P, Nair S. Refining Mouse Models of Gaucher Disease: Advancing Mechanistic Insights, Biomarker Discovery, and Therapeutic Strategies. International Journal Of Molecular Sciences 2025, 26: 11915. PMID: 41465340, PMCID: PMC12733336, DOI: 10.3390/ijms262411915.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrecision genomic profiling in Gaucher disease: insights from atypical presentations
Saith A, Ain N, Ruan J, Kasaiyan M, Jain D, Israel G, Mehta S, Bamford N, Nair S, Mistry P. Precision genomic profiling in Gaucher disease: insights from atypical presentations. Frontiers In Genetics 2025, 16: 1553036. PMID: 41282474, PMCID: PMC12634035, DOI: 10.3389/fgene.2025.1553036.Peer-Reviewed Original ResearchSynaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies
Vidyadhara D, Bäckström D, Chakraborty R, Ruan J, Park J, Mistry P, Chandra S. Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies. Nature Communications 2025, 16: 8484. PMID: 41006254, PMCID: PMC12475166, DOI: 10.1038/s41467-025-63444-9.Peer-Reviewed Original ResearchModeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion
Belinsky G, Ruan J, Fattahi N, Mehta S, Boddupalli C, Mistry P, Nair S. Modeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion. Human Molecular Genetics 2025, 34: 952-966. PMID: 40197748, PMCID: PMC12085781, DOI: 10.1093/hmg/ddaf045.Peer-Reviewed Original Research
2023
Osteonecrosis in Gaucher disease in the era of multiple therapies: Biomarker set for risk stratification from a tertiary referral center
Basiri M, Ghaffari M, Ruan J, Murugesan V, Kleytman N, Belinsky G, Akhavan A, Lischuk A, Guo L, Klinger K, Mistry P. Osteonecrosis in Gaucher disease in the era of multiple therapies: Biomarker set for risk stratification from a tertiary referral center. ELife 2023, 12: e87537. PMID: 37249220, PMCID: PMC10317498, DOI: 10.7554/elife.87537.Peer-Reviewed Original Research
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Contacts
Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States