2018
Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2
Zhang J, Chen C, Li L, Zhou HJ, Li F, Zhang H, Yu L, Chen Y, Min W. Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2. Frontiers In Physiology 2018, 9: 396. PMID: 29731721, PMCID: PMC5921534, DOI: 10.3389/fphys.2018.00396.Peer-Reviewed Original ResearchIntima-media thickeningVascular smooth muscle cellsEarly time pointsCytosolic subunit p47phoxLigation modelVascular remodelingReactive oxygen speciesVessel dysfunctionIntima/media ratioNOX2 complexMouse carotid artery ligation modelEndothelial cellsSubunit p47phoxCarotid artery ligation modelTime pointsNADPH oxidase 2Artery ligation modelROS productionHuman atherosclerotic plaquesSmooth muscle cellsCarotid ligation modelVSMC accumulationIntima areaApoE-KO mouse modelVascular disease
2017
Smooth muscle cell differentiation: Mechanisms and models for vascular diseases
Deng Y, Lin C, Zhou H, Min W. Smooth muscle cell differentiation: Mechanisms and models for vascular diseases. Frontiers In Biology 2017, 12: 392-405. DOI: 10.1007/s11515-017-1473-z.Peer-Reviewed Original ResearchVSMC differentiationVascular diseaseVSMC behaviorEnvironmental cuesVSMC phenotypeMolecular mechanismsPhenotypic switchingPhenotype modulationMature cellsNew therapeutic targetsSynthetic stateProgenitor cellsSmooth muscle cellsMuscle cellsCritical roleVascular-related diseasesTherapeutic targetDifferentiationCardiovascular diseaseCardiovascular conditionsCellsContractile stateDiseaseComprehensive understandingPhenotype