The tumor suppressor CDKN3 controls mitosis
Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen J, Lehmann A, Park S, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang F, Parada L, Clapp W. The tumor suppressor CDKN3 controls mitosis. Journal Of Cell Biology 2013, 201: 997-1012. PMID: 23775190, PMCID: PMC3691455, DOI: 10.1083/jcb.201205125.Peer-Reviewed Original ResearchConceptsLibrary of small interfering RNAsLocalizes to mitotic centrosomesGenome-wide setNetwork of kinasesSignaling axisMass spectrometry screeningSmall interfering RNAEarly mitosisMitotic exitSubcellular localizationHuman phosphatasesSpindle checkpointMitotic centrosomesSerine 209Normal mitosisCell cycleG1/S transitionCDKN3MitosisTargeted anticancer therapeuticsDown-regulationCdc2CentrosomeAnticancer therapeuticsPhosphatase