2021
Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso
Compaoré Y, Zongo I, Somé A, Barry N, Nikiéma F, Kaboré T, Ouattara A, Kabré Z, Wermi K, Zongo M, Yerbanga R, Sagara I, Djimdé A, Ouédraogo J. Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso. Malaria Journal 2021, 20: 64. PMID: 33514368, PMCID: PMC7847156, DOI: 10.1186/s12936-021-03593-6.Peer-Reviewed Original ResearchConceptsHepatic adverse eventsArtemether-lumefantrineAL armAdverse eventsElevated ALTMalaria episodesUncomplicated malariaHepatic safetyDirect bilirubinPA armFirst-line anti-malarial drugHepatic safety profileUncomplicated malaria episodesElevated total bilirubinBobo-DioulassoLogistic regression modelsAnti-malarial drugsAlkaline phosphataseSubsequent malariaUnscheduled daysStudy armsSafety profileResultsA totalClinical trialsTotal bilirubin
2019
Liver retinol estimated by 13C-retinol isotope dilution at 7 versus 14 days in Burkinabe schoolchildren
Bationo J, Zeba A, Coulibaly N, Sheftel J, Davis C, Bassole I, Barro N, Ouedraogo J, Tanumihardjo S. Liver retinol estimated by 13C-retinol isotope dilution at 7 versus 14 days in Burkinabe schoolchildren. Experimental Biology And Medicine 2019, 244: 1430-1437. PMID: 31547685, PMCID: PMC6900701, DOI: 10.1177/1535370219877132.Peer-Reviewed Original ResearchConceptsBody surface areaTotal liver vitaminBlood drawLiver massBody weightDay 7Liver vitaminLiver weightDay 14TLR valuesBaseline blood drawSerum retinol concentrationsTotal-body vitaminTotal body storesDilution testingRetinol isotope dilutionPublic health programsLiver reserveLiver biopsyLiver retinolRetinol concentrationsSchool-aged childrenAdequate vitaminTracer doseBlood samples