2024
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
Datoo M, Dicko A, Tinto H, Ouédraogo J, Hamaluba M, Olotu A, Beaumont E, Lopez F, Natama H, Weston S, Chemba M, Compaore Y, Issiaka D, Salou D, Some A, Omenda S, Lawrie A, Bejon P, Rao H, Chandramohan D, Roberts R, Bharati S, Stockdale L, Gairola S, Greenwood B, Ewer K, Bradley J, Kulkarni P, Shaligram U, Hill A, Group R, Mahamar A, Sanogo K, Sidibe Y, Diarra K, Samassekou M, Attaher O, Tapily A, Diallo M, Dicko O, Kaya M, Maguiraga S, Sankare Y, Yalcouye H, Diarra S, Niambele S, Thera I, Sagara I, Sylla M, Dolo A, Misidai N, Simando S, Msami H, Juma O, Gutapaka N, Paul R, Mswata S, Sasamalo I, Johaness K, Sultan M, Alexander A, Kimaro I, Lwanga K, Mtungwe M, Khamis K, Rugarabam L, Kalinga W, Mohammed M, Kamange J, Msangi J, Mwaijande B, Mtaka I, Mhapa M, Mlaganile T, Mbaga T, Yerbanga R, Samtouma W, Sienou A, Kabre Z, Ouedraogo W, Yarbanga G, Zongo I, Savadogo H, Sanon J, Compaore J, Kere I, Yoni F, Sanre T, Ouattara S, Provstgaard-Morys S, Woods D, Snow R, Amek N, Ngetsa C, Ochola-Oyier L, Musyoki J, Munene M, Mumba N, Adetifa U, Muiruri C, Mwawaka J, Mwaganyuma M, Ndichu M, Weya J, Njogu K, Grant J, Webster J, Lakhkar A, Ido N, Traore O, Tahita M, Bonko M, Rouamba T, Ouedraogo D, Soma R, Millogo A, Ouedraogo E, Sorgho F, Konate F, Valea I. Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial. The Lancet 2024, 403: 533-544. PMID: 38310910, DOI: 10.1016/s0140-6736(23)02511-4.Peer-Reviewed Original ResearchConceptsClinical malaria episodesPhase 3 trialMalaria episodesMonths age groupAdverse eventsVaccine efficacyClinical malariaMalaria vaccineDouble-blindMalaria transmissionControl vaccineAsn-Ala-Asn-ProAge groupsStandard sitesMonths of follow-upAfrican childrenPerennial malaria transmissionBurden of malariaSeasonal malaria transmissionMalaria transmission intensityPhase 2b trialInjection site painFrequent adverse eventsCo-primary endpointsVaccine-induced antibodies
2023
Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso
Diawara H, Bocoum F, Dicko A, Levin A, Lee C, Koita F, Ouédraogo J, Guissou R, Yabré S, Traoré S, Morgan W, Pecenka C, Baral R. Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso. BMJ Global Health 2023, 8: e011316. PMID: 37068848, PMCID: PMC10111920, DOI: 10.1136/bmjgh-2022-011316.Peer-Reviewed Original ResearchConceptsVaccine deliverySeasonal vaccinationMalaria vaccineMalaria transmissionSeasonal malaria transmissionRoutine Expanded ProgrammeResource use dataRoutine EPINew vaccine introductionSeasonal malariaVaccine introductionMain cost driversHealth facilitiesExpanded ProgrammeVaccine priceVaccine rolloutMass campaignsService deliveryYoung childrenVaccinationCost consequencesBurkina FasoFinancial costsVaccineDelivery approach
2022
The Strategy of Paratransgenesis for the Control of Malaria Transmission
Fofana A, Yerbanga R, Bilgo E, Ouedraogo G, Gendrin M, Ouedraogo J. The Strategy of Paratransgenesis for the Control of Malaria Transmission. Frontiers In Tropical Diseases 2022, 3: 867104. DOI: 10.3389/fitd.2022.867104.Peer-Reviewed Original ResearchMalaria parasitesGenetic engineering strategiesParatransgenesis approachWHO African RegionInsect-borne diseasesInsect hostsVector control measuresSpread of resistanceInsect vectorsImportant burdenGlobal deathsMalaria transmissionPlasmodium transmissionMalariaMicrobial strainsParatransgenesisSubtropical countriesEngineering strategiesDiseaseDeathParasitesControl measuresNovel strategyMosquitoesDifferent stepsDelivery of seasonal malaria chemoprevention with enhanced infection prevention and control measures during the COVID-19 pandemic in Nigeria, Burkina Faso and Chad: a cross-sectional study
Ward C, Phillips A, Oresanya O, Olisenekwu G, Arogunade E, Moukénet A, Beakgoubé H, De Paul Allambademel V, Compaoré C, Traoré A, Ouedraogo J, Compaoré Y, Zongo I, Donovan L, Decola M, Smith H, Baker K. Delivery of seasonal malaria chemoprevention with enhanced infection prevention and control measures during the COVID-19 pandemic in Nigeria, Burkina Faso and Chad: a cross-sectional study. Malaria Journal 2022, 21: 103. PMID: 35331248, PMCID: PMC8943494, DOI: 10.1186/s12936-022-04091-z.Peer-Reviewed Original ResearchConceptsCross-sectional studyIPC measuresMalaria chemopreventionInfection preventionMethodsA cross-sectional studyEnhanced infection preventionSeasonal malaria chemopreventionCoronavirus disease 2019 (COVID-19) transmissionHigh malaria transmissionOptimal hand hygiene practicesHand hygiene practicesProportion of indicationsCOVID-19 pandemicEarly community engagementFirst doseHand hygieneWHO guidanceMalaria transmissionBurkina FasoHand washingControl measuresHygiene practicesProtective equipmentAdherenceBlister packs
2021
Analyzing gut microbiota composition in individual Anopheles mosquitoes after experimental treatment
Fofana A, Gendrin M, Romoli O, Yarbanga G, Ouédraogo G, Yerbanga R, Ouédraogo J. Analyzing gut microbiota composition in individual Anopheles mosquitoes after experimental treatment. IScience 2021, 24: 103416. PMID: 34901787, PMCID: PMC8637483, DOI: 10.1016/j.isci.2021.103416.Peer-Reviewed Original ResearchMosquito microbiotaHigh-throughput sequencing studiesHigh-throughput sequencingMosquito microbiomeMicrobiota compositionBlood digestionSemi-field conditionsMajor generaSequencing studiesGut samplesReduced microbial loadRelative abundanceMalaria transmissionOverall microbiota compositionBlood mealGut microbiota compositionInfluence of amoxicillinAnopheles mosquitoesAdult femalesNegative control dataMicrobiotaAntibiotic treatmentSpecific decreaseAmoxicillin preparationsMicrobial loadEffect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness
Yaméogo K, Yerbanga R, Ouattara S, Yao F, Lefèvre T, Zongo I, Nikièma F, Compaoré Y, Tinto H, Chandramohan D, Greenwood B, Belem A, Cohuet A, Ouédraogo J. Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness. Malaria Journal 2021, 20: 326. PMID: 34315475, PMCID: PMC8314489, DOI: 10.1186/s12936-021-03855-3.Peer-Reviewed Original ResearchConceptsAddition of azithromycinMalaria chemopreventionSulfadoxine-pyrimethamineGametocyte infectivityAsexual Plasmodium falciparumDirect membrane feeding assaysSeasonal malaria chemopreventionPlacebo-controlled trialPlasmodium falciparum transmissionMembrane feeding assaysInfectivity of gametocytesControl of malariaPresence of malariaMalaria transmission periodDays post treatmentAnopheles gambiae mosquitoesGametocyte prevalenceMethodsThe studyConclusionThis studyMalaria transmissionP. falciparumControl childrenMosquito transmissionAppropriate interventionsChemoprevention
2020
High Plasmodium infection intensity in naturally infected malaria vectors in Africa
Bompard A, Da D, Yerbanga S, Morlais I, Awono-Ambéné P, Dabiré R, Ouédraogo J, Lefèvre T, Churcher T, Cohuet A. High Plasmodium infection intensity in naturally infected malaria vectors in Africa. International Journal For Parasitology 2020, 50: 985-996. PMID: 32681932, DOI: 10.1016/j.ijpara.2020.05.012.Peer-Reviewed Original ResearchConceptsOocyst-positive mosquitoesInfectious blood mealEfficacy of transmissionControl of malariaWild malaria vectorsMalaria parasite transmissionCross-sectional surveyInfection loadSalivary gland sporozoitesMalaria vectorsMalaria endemicityNumber of oocystsInfected mosquitoesMalaria transmissionOocyst prevalenceStrong positive associationPrevalencePositive associationBlood mealOocyst loadInfection intensityEpidemiologyEfficacyParasite transmissionIntervention
2017
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine
Greenwood B, Dicko A, Sagara I, Zongo I, Tinto H, Cairns M, Kuepfer I, Milligan P, Ouedraogo J, Doumbo O, Chandramohan D. Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine. Malaria Journal 2017, 16: 182. PMID: 28464937, PMCID: PMC5414195, DOI: 10.1186/s12936-017-1841-9.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMalaria vaccineTransmission seasonEffective malaria control measuresEffective immunological memoryMalaria transmission seasonHigh transmission seasonMass vaccination campaignMalaria control measuresHigh initial efficacyMalaria chemopreventionSeasonal vaccinationSulfadoxine-pyrimethamineMalaria infectionMalaria treatmentImmunological memoryPilot implementation projectVaccination campaignInitial efficacyFull courseMalaria transmissionVaccineEuropean Medicines AuthorityHealthcare giversMajor causeComparison of effectiveness of two different artemisinin-based combination therapies in an area with high seasonal transmission of malaria in Burkina Faso
Sondo P, Derra K, Nakanabo S, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Ouédraogo J, Guiguemdé T, Tinto H. Comparison of effectiveness of two different artemisinin-based combination therapies in an area with high seasonal transmission of malaria in Burkina Faso. Annals Of Parasitology 2017, 63: 127-131. PMID: 28822205, DOI: 10.17420/ap6302.96.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrine groupsCure rateArtemether-lumefantrineHigh incidenceDifferent artemisinin-based combination therapiesMalaria transmissionPost-treatment prophylactic effectRandomized open-label trialArtemisinin-based combination therapyArtesunate-amodiaquine treatmentHigh seasonal transmissionUncorrected cure ratesOpen-label trialUncomplicated falciparum malariaMerozoite surface protein 1Surface protein 1Antimalarial regimensArtesunate-AmodiaquinePCR adjustmentLabel trialUncomplicated malariaFalciparum malariaMalaria episodesRecurrent parasitaemiaComparison of effectiveness
2016
Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
Hien D, Dabiré K, Roche B, Diabaté A, Yerbanga R, Cohuet A, Yameogo B, Gouagna L, Hopkins R, Ouedraogo G, Simard F, Ouedraogo J, Ignell R, Lefevre T. Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria. PLOS Pathogens 2016, 12: e1005773. PMID: 27490374, PMCID: PMC4973987, DOI: 10.1371/journal.ppat.1005773.Peer-Reviewed Original ResearchConceptsImportant African malaria vectorsHost resource availabilityMalaria parasitesMalaria vectorsSugar sourcesSugar mealsAfrican malaria vectorsToxic secondary metabolitesNutritional ecologyPlant speciesMosquito traitsMosquito competenceNatural diversityFeeding assaysLannea microcarpaMosquito's capacityEcological contextSecondary metabolitesMolecular aspectsMalaria transmissionParasite growthResource availabilityDirect membrane feeding assaysDevelopment durationHuman malariaDifferential Effects of Azithromycin, Doxycycline, and Cotrimoxazole in Ingested Blood on the Vectorial Capacity of Malaria Mosquitoes
Gendrin M, Yerbanga R, Ouedraogo J, Lefèvre T, Cohuet A, Christophides G. Differential Effects of Azithromycin, Doxycycline, and Cotrimoxazole in Ingested Blood on the Vectorial Capacity of Malaria Mosquitoes. Open Forum Infectious Diseases 2016, 3: ofw074. PMID: 27419152, PMCID: PMC4943539, DOI: 10.1093/ofid/ofw074.Peer-Reviewed Original ResearchIngested bloodMass drug administration programsMosquito lifespanEffect of doxycyclineDrug administration programsMosquito vectorial capacityAntibiotic treatmentMosquito microbiotaPlasmodium infectionBlood meal supplementationInfection loadVectorial capacityGut microbiotaMalaria transmissionAzithromycinMalaria parasitesPlasmodium falciparumDisease eliminationDoxycyclineMalaria vector mosquitoesAntibioticsBlood mealDifferential effectsInfection intensityMicrobiota
2015
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso
Zongo I, Milligan P, Compaore Y, Some A, Greenwood B, Tarning J, Rosenthal P, Sutherland C, Nosten F, Ouedraogo J. Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. Antimicrobial Agents And Chemotherapy 2015, 59: 4387-4396. PMID: 25918149, PMCID: PMC4505196, DOI: 10.1128/aac.04923-14.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMalaria chemopreventionAlternative drugsControl groupPrimary outcome measureSeasonal malaria transmissionRandomized noninferiority trialPotential alternative drugDihydroartemisinin-PiperaquinePfdhps mutationsClinical malariaMalaria attacksSulfadoxine-pyrimethamineOdds ratioNoninferiority trialOutcome measuresDHAPQChildren 3Malaria transmissionDrug resistanceAntifolate resistanceChemopreventionChildrenAmodiaquineTrialsAntibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
Gendrin M, Rodgers F, Yerbanga R, Ouédraogo J, Basáñez M, Cohuet A, Christophides G. Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria. Nature Communications 2015, 6: 5921. PMID: 25562286, PMCID: PMC4338536, DOI: 10.1038/ncomms6921.Peer-Reviewed Original ResearchConceptsMass drug administration programsHigh antibiotic usageDrug administration programsBlood of childrenAnopheles gambiae mosquitoesMalaria infectionAntibiotic exposureMosquito bitesHigh riskAntibiotic usageMalaria reductionGut microbiotaMalaria transmissionCommunicable diseasesPlasmodium falciparumBloodIngested bloodGambiae mosquitoesAntibioticsHuman bloodDisease transmissionDiseaseMosquito survivalMosquito microbiotaVectorial capacity
1994
Ten-year surveillance of drug-resistant malaria in Burkina Faso (1982-1991).
Guiguemde T, Aouba A, Ouedraogo J, Lamizana L. Ten-year surveillance of drug-resistant malaria in Burkina Faso (1982-1991). American Journal Of Tropical Medicine And Hygiene 1994, 50: 699-704. PMID: 8024062, DOI: 10.4269/ajtmh.1994.50.699.Peer-Reviewed Original ResearchConceptsTen-year surveillanceBobo-DioulassoDrug-resistant malariaDrug-resistant formsPrevalence of resistanceFirst caseChloroquine sensitivityVivo resistanceCases of resistanceMalaria transmissionBurkina FasoPlasmodium falciparumMefloquineHigh rateMalariaPyrimethamineChloroquineVitroVivoActive surveyLevel of resistancePrevalence
1990
Vaccination against malaria: initial trial with an ant-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso).
Guiguemdé T, Sturchler D, Ouédraogo J, Drabo M, Etlinger H, Douchet C, Gbary A, Haller L, Kambou S, Fernex M. Vaccination against malaria: initial trial with an ant-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso). Bulletin De La Société De Pathologie Exotique 1990, 83: 217-27. PMID: 2119897.Peer-Reviewed Original ResearchConceptsDoses of TTAntibody titresCircumsporozoite proteinAverage antibody titresPeak IgG responseMonths of ageClinical malariaIgG responsesSystemic reactionsProtective efficacyVaccine trialsImmunological statusImmunisation vaccinesTetanus toxoidProtective effectGroup IIMalaria transmissionDay 0VaccineGroup IGroup IIIPlasmodium falciparumDay 75MalariaDay 150