2024
COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional decline
2023
Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children
Politis M, Gutiérrez-Avila I, Just A, Pizano-Zárate M, Tamayo-Ortiz M, Greenberg J, Téllez-Rojo M, Sanders A, Rosa M. Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children. The Science Of The Total Environment 2023, 907: 168119. PMID: 37884142, PMCID: PMC10842020, DOI: 10.1016/j.scitotenv.2023.168119.Peer-Reviewed Original ResearchConceptsDistributed lag nonlinear modelParticulate matterAverage PM<sub>2.5</sub>Satellite-based spatio-temporal modelUrinary kidney injury biomarkersFine particulate matterExposure to ambient temperatureAir pollutionAerodynamic diameterBirth cohort studySpatio-temporal modelParticipating residentsCohort studyLimited researchEnvironmental exposuresMean temperatureDaily mean temperatureVisitsDaily temperatureAmbient temperatureMatterExposurePM2.5Linear regressionPollutionWCN23-0514 Long-term kidney outcomes following pediatric acute kidney injury not receiving dialysis: A population-based propensity-matched cohort study
Robinson C, Jeyakumar N, Luo B, Askenazi D, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Thabane L, Wald R, Zappitelli M, Chanchlani R. WCN23-0514 Long-term kidney outcomes following pediatric acute kidney injury not receiving dialysis: A population-based propensity-matched cohort study. Kidney International Reports 2023, 8: s8-s9. DOI: 10.1016/j.ekir.2023.02.019.Peer-Reviewed Original Research
2022
Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children
Politis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.Peer-Reviewed Original ResearchKidney injury biomarkersInjury biomarkersKidney biomarkersGamma-induced protein 10Glomerular filtration rateBirth cohort studyAlpha-1-microglobulinQuantile sum (WQS) regressionPrenatal metal exposureKidney injuryCohort studyUrinary CdPregnant womenSecond trimesterKidney diseasePrenatal exposureFiltration rateCystatin CUrinary metalsNull associationProtein 10A1MMetal exposureBiomarkersProtein 1
2021
Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study
Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdolescentCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansHypertensionIncidenceInfantInfant, NewbornKidney Failure, ChronicMaleMortalityOntarioProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSurvivorsTime FactorsConceptsAKI survivorsKidney failureLong-term riskCohort studyCox proportional hazards regression analysisAdverse short-term outcomesChildhood acute kidney injuryProportional hazards regression analysisHigher long-term riskAcute kidney injuryHealth administrative databasesRetrospective cohort studyHazards regression analysisShort-term outcomesLong-term outcomesBasis of ageAKI episodesPediatric AKISubsequent AKIKidney injuryComposite outcomeCardiac surgeryHospitalized cohortMechanical ventilationPediatric hospitalizations