2020
Switching warfarin to direct oral anticoagulants in atrial fibrillation: Insights from the NCDR PINNACLE registry
Sciria CT, Maddox TM, Marzec L, Rodwin B, Virani SS, Annapureddy A, Freeman JV, O'Hare A, Liu Y, Song Y, Doros G, Zheng Y, Lee JJ, Daggubati R, Vadlamani L, Cannon C, Desai NR. Switching warfarin to direct oral anticoagulants in atrial fibrillation: Insights from the NCDR PINNACLE registry. Clinical Cardiology 2020, 43: 743-751. PMID: 32378265, PMCID: PMC7368350, DOI: 10.1002/clc.23376.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsAF patientsAtrial fibrillationOral anticoagulantsAvailability of DOACsChronic warfarin therapyMultivariable hierarchical regressionNCDR PINNACLE RegistryPattern of anticoagulationProspective cohort studyPractice-level factorsPractice-level variationPINNACLE RegistryPrescribed warfarinSwitched patientsClinical characteristicsCohort studyStroke riskWarfarin therapyCurrent guidelinesPatientsWarfarinAnticoagulationPrivate insuranceSignificant predictors
2018
Association of Atrial Fibrillation Clinical Phenotypes with Treatment Patterns and Outcomes: A Multicenter Registry Study
Inohara T, Shrader P, Pieper K, Blanco RG, Thomas L, Singer DE, Freeman JV, Allen LA, Fonarow GC, Gersh B, Ezekowitz MD, Kowey PR, Reiffel JA, Naccarelli GV, Chan PS, Steinberg BA, Peterson ED, Piccini JP. Association of Atrial Fibrillation Clinical Phenotypes with Treatment Patterns and Outcomes: A Multicenter Registry Study. JAMA Cardiology 2018, 3: 54-63. PMID: 29128866, PMCID: PMC5833527, DOI: 10.1001/jamacardio.2017.4665.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAtherosclerotic comorbiditiesMajor bleedingComorbidity clustersNeurological eventsClinical outcomesDevice implantationORBIT-AF II registryPrior coronary artery diseaseAtrial Fibrillation RegistryComorbid behavioral disordersMulticenter registry studyBaseline clinical characteristicsImportance of comorbiditiesBetter Informed TreatmentSinus node dysfunctionCoronary artery diseaseData-driven cluster analysisHemostasis criteriaClinical characteristicsObservational cohortRegistry studyTotal patientsArtery diseaseAtrial size
2015
Heart rate is associated with progression of atrial fibrillation, independent of rhythm
Holmqvist F, Kim S, Steinberg BA, Reiffel JA, Mahaffey KW, Gersh BJ, Fonarow GC, Naccarelli GV, Chang P, Freeman JV, Kowey PR, Thomas L, Peterson ED, Piccini JP. Heart rate is associated with progression of atrial fibrillation, independent of rhythm. Heart 2015, 101: 894. PMID: 25732748, PMCID: PMC4453487, DOI: 10.1136/heartjnl-2014-307043.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAF progressionHeart rateBaseline ECGRhythm control strategyBetter Informed TreatmentPredictors of progressionPersistent atrial fibrillationModest discriminatory powerLower heart rateHigher heart rateMore comorbiditiesOutcomes RegistryPatientsClinical practiceInformed TreatmentProgressionStrongest predictorFibrillationPredictorsBaselineAgeECGSustained formsSignificant interaction
2014
Digoxin and Risk of Death in Adults With Atrial Fibrillation
Freeman JV, Reynolds K, Fang M, Udaltsova N, Steimle A, Pomernacki NK, Borowsky LH, Harrison TN, Singer DE, Go AS. Digoxin and Risk of Death in Adults With Atrial Fibrillation. Circulation Arrhythmia And Electrophysiology 2014, 8: 49-58. PMID: 25414270, PMCID: PMC4334705, DOI: 10.1161/circep.114.002292.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAnti-Arrhythmia AgentsAtrial FibrillationCaliforniaChi-Square DistributionDigoxinFemaleHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedPatient SelectionPropensity ScoreProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsRisk of deathIncident atrial fibrillationAtrial fibrillationDigoxin useHigh riskHeart failureIndependent associationPropensity score-matched adultsKaiser Permanente NorthernPrevious heart failureRetrospective cohort studyResearch Network StudySubgroups of ageCohort studyCox regressionAdverse outcomesRisk factorsHospitalizationFibrillationDigoxinDeathLimited dataAdultsRiskHigh rate
2012
Effectiveness of Implantable Cardioverter Defibrillators and Cardiac Resynchronization Therapy in Heart Failure
Freeman JV, Masoudi FA. Effectiveness of Implantable Cardioverter Defibrillators and Cardiac Resynchronization Therapy in Heart Failure. Heart Failure Clinics 2012, 9: 59-77. PMID: 23168318, DOI: 10.1016/j.hfc.2012.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedCardiac Resynchronization TherapyComparative Effectiveness ResearchDefibrillators, ImplantableDisease ManagementFemaleHeart FailureHumansMaleMeta-Analysis as TopicMiddle AgedObservationOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicRandomized Controlled Trials as TopicSecondary PreventionSeverity of Illness IndexSex FactorsSurvival RateConceptsCardiac resynchronization therapyTrial dataResynchronization therapyQRS morphologyNYHA class IV patientsCardiac devicesBenefit of ICDSingle-chamber ICDClass IV patientsHigh-volume hospitalsOptimal medical managementEffective treatment modalityPrior ventricular arrhythmiasProlonged QRS complexRecent trial dataRecent trial resultsImplantable cardioverter defibrillatorQuality of lifeHF hospitalizationSymptomatic HFHF symptomsICD therapySevere comorbiditiesIV patientsMortality benefit
2011
The Impact of ST Elevation on Athletic Screening
Leo T, Uberoi A, Jain NA, Garza D, Chowdhury S, Freeman JV, Perez M, Ashley E, Froelicher V. The Impact of ST Elevation on Athletic Screening. Clinical Journal Of Sport Medicine 2011, 21: 433-440. PMID: 21892017, DOI: 10.1097/jsm.0b013e31822cf105.Peer-Reviewed Original ResearchConceptsST elevationCardiac eventsCardiac deathEarly repolarizationVeterans Affairs Palo Alto Health Care SystemRetrospective cohort studyAbnormal test resultsClinical patient cohortUniversity varsity athletesHealth care systemCardiovascular mortalityCohort studyClinical outcomesAmbulatory individualsVital statusAthletic screeningECG abnormalitiesPatient cohortLateral leadsMyocardial ischemiaBrugada syndromeHigh prevalenceCardiac conditionsHeart rateJ waves
2009
The ageing athlete: screening prior to vigorous exertion in asymptomatic adults without known cardiovascular disease
Freeman J, Froelicher V, Ashley E. The ageing athlete: screening prior to vigorous exertion in asymptomatic adults without known cardiovascular disease. British Journal Of Sports Medicine 2009, 43: 696. PMID: 19734505, DOI: 10.1136/bjsm.2008.054783.Peer-Reviewed Original ResearchConceptsExercise ECG testingVigorous exercise programRisk factorsObservational studyECG testingCV eventsAsymptomatic patientsAsymptomatic menAsymptomatic adultsExercise programPrognostic valueExercise electrocardiogramCardiovascular diseaseMore CV risk factorsMultiple cardiac risk factorsAsymptomatic healthy womenIncident CV eventsCardiac risk factorsCV risk factorsProspective observational studySimilar prognostic valueExercise ECG testMore conclusive dataRisk factor exposureElderly patients