2010
Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease. New England Journal Of Medicine 2010, 362: 1082-1089. PMID: 20335584, PMCID: PMC2976042, DOI: 10.1056/nejmoa0907295.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseasePlasma triglyceride clearanceLiver diseaseFat tolerance testPlasma triglyceride concentrationsInsulin resistanceApolipoprotein C3Wild-type homozygotesIndian menTriglyceride clearanceTriglyceride concentrationsC3 concentrationsTriglyceride contentApolipoprotein C3 gene variantsHealthy Asian Indian menOral fat tolerance testType 2 diabetes mellitusVariant allelesIntravenous fat tolerance testLiver triglyceride contentHepatic triglyceride contentSingle nucleotide polymorphismsVariant allele carriersHepatic insulin resistance
2009
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia. Diabetes 2009, 58: 1237-1244. PMID: 19223595, PMCID: PMC2671041, DOI: 10.2337/db08-1557.Peer-Reviewed Original ResearchConceptsType 1 diabetic subjectsMedium-chain triglyceridesSynaptic transmissionDiabetic subjectsMedium-chain triglyceride ingestionType 1 diabetic patientsRat hippocampal slice preparationHippocampal synaptic transmissionBeta-hydroxybutyrate levelsType 1 diabetesHypoglycemic clamp studiesHippocampal slice preparationControl glucose concentrationsTriglyceride ingestionDiabetic patientsFatty acidsAcute hypoglycemiaSymptomatic responseHippocampal slicesSlice preparationFree fatty acidsGlucose levelsClamp studiesTherapeutic advantageNeuronal activity
2007
Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents
Liska D, Dufour S, Zern TL, Taksali S, Calí AM, Dziura J, Shulman GI, Pierpont BM, Caprio S. Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents. PLOS ONE 2007, 2: e569. PMID: 17593968, PMCID: PMC1892806, DOI: 10.1371/journal.pone.0000569.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingLiver fat contentHepatic fat contentInsulin resistanceObese adolescentsAfrican AmericansOral glucose tolerance testingObese Hispanic adolescentsAbdominal fat distributionGlucose tolerance testingType 2 diabetesTotal body fatEthnic differencesClear ethnic differencesVisceral fatInsulin sensitivityFat distributionTolerance testingIMCL levelsMultiethnic cohortObese youthFat contentAbdominal cavityBody fatSoleus muscle
2006
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Man C, Cobelli C, Shulman GI. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18273-18277. PMID: 17114290, PMCID: PMC1693873, DOI: 10.1073/pnas.0608537103.Peer-Reviewed Original ResearchConceptsAsian Indian menInsulin resistanceInsulin sensitivity indexLiver diseaseNonalcoholic fatty liver diseaseOral glucose tolerance testType 2 diabetes mellitusAsian IndiansWhole-body insulin sensitivityFatty liver diseaseIL-6 concentrationsTreatment of T2DMIntramyocellular lipid contentGlucose tolerance testPathogenesis of T2DMProton magnetic resonance spectroscopyImportant therapeutic implicationsEthnic groupsDiabetes mellitusImportant ethnic differencesCaucasian manTolerance testInsulin sensitivityIntramyocellular lipidsLean individualsAdiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokines
2005
Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET)
Cartmel B, Dziura J, Cullen MR, Vegso S, Omenn GS, Goodman GE, Redlich CA. Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET). European Journal Of Clinical Nutrition 2005, 59: 1173-1180. PMID: 16015255, DOI: 10.1038/sj.ejcn.1602229.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialPlacebo armSerum triglyceridesTriglyceride concentrationsEfficacy trialsVitamin ASerum cholesterol concentrationActive intervention armsActive intervention groupNational Cancer InstituteCardiovascular deathPlacebo groupCardiovascular mortalitySerum lipidsTotal cholesterolIntervention armSerum cholesterolVanguard StudyLung cancerIntervention groupCardiovascular diseaseCancer InstituteCholesterol concentrationsActive armBeta carotene
2003
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science 2003, 300: 1140-1142. PMID: 12750520, PMCID: PMC3004429, DOI: 10.1126/science.1082889.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentAdultAgedAged, 80 and overAgingBlood GlucoseBody Mass IndexFemaleHumansInsulinInsulin ResistanceLiverMaleMiddle AgedMitochondriaMitochondrial DiseasesMuscle, SkeletalNuclear Magnetic Resonance, BiomolecularOxidation-ReductionOxygen ConsumptionPhosphorylationTriglyceridesConceptsInsulin resistanceInsulin-stimulated muscle glucose metabolismType 2 diabetesMuscle glucose metabolismLean body massElderly study participantsAge-associated declineMitochondrial function contributesFat massFat accumulationGlucose metabolismYoung controlsStudy participantsLiver tissueFunction contributesMitochondrial dysfunctionYounger participantsPossible roleMitochondrial oxidativeBody massMagnetic resonance spectroscopyParticipantsDiabetesDysfunctionPathogenesisLow Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation
Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S. Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2014-2018. PMID: 12727947, DOI: 10.1210/jc.2002-021711.Peer-Reviewed Original ResearchConceptsAdiponectin levelsInsulin sensitivityAdolescent obesityObese adolescentsPutative modulatory effectsLower adiponectin levelsAbdominal fat distributionIntramyocellular lipid contentPlasma adiponectin levelsIntramyocellular lipid accumulationEuglycemic hyperinsulinemic clampTotal body fatMagnetic resonance imagingCentral adiposityPediatric populationInsulin resistanceIntramuscular lipid contentTriglyceride levelsFat distributionLipid contentPlasma triglyceridesFree fatty acidsBody fatModulatory effectsAdiponectin