Huixiao Chen, PhD, DABR
Assistant Professor of Therapeutic RadiologyCards
About
Titles
Assistant Professor of Therapeutic Radiology
Clinical Medical Physicist II, Therapeutic Radiology
Biography
Dr. Huixiao Chen received her B.S. and M.S. in Biomedical Engineering and Bioelectromagnetics at Zhejiang University, China. After her master degree, she joined the department of radiation oncology of 2nd affiliated hospital of Zhejiang University as a medical physicist for five years. In 2004, she was enrolled in the German academic and culture exchange program (DAAD) with one-year certificate German language and culture training in Shanghai Tongji University and Goethe-Institut Frankfurt. Afterward, she started her PhD majoring in medical physics in the department of radiation oncology of Mannheim Medical Center of Heidelberg University, Germany, courtesy of DAAD. Following her degrees, and for family reasons, she moved to USA in 2010 and finished her one-year postdoctoral training in the department of radiation oncology of Virginia Commonwealth University, which followed by a two-year postdoctoral training in the department of radiation oncology of Massachusetts General Hospital of Harvard University. In 2016, she joined the Yale medical physic team after she completed her medical physics residency training in the department of Therapeutic Radiology at Yale University School of Medicine; gaining the rank of clinical assistant professor.
Appointments
Therapeutic Radiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Resident
- Yale Univeristy (2016)
- Postdoc
- Harvard University (2013)
- Postdoc
- Virginia Commonwealth University (2011)
- PhD
- University of Heidelberg/Germany (2010)
- MS
- Zhejiang University/China (1998)
- BS
- Zhejiang Univeristy/China (1995)
Research
Publications
2025
Commissioning of the RefleXion X1 Linear Accelerator and Development of a Consensus Reference Beam Model.
Watkins WT, Yang R, Han C, Liu A, Surucu M, Kovalchuk N, Han B, Cai B, Banks TI, Shen C, Lalonde R, Dimitriadou D, Chang J, Huq MS, Forbang RT, Ndlovu AM, Ku L, Maganti S, Chen H, Chen ZJ, Carlson DJ. Commissioning of the RefleXion X1 Linear Accelerator and Development of a Consensus Reference Beam Model. Med Phys 2025, 52: e70173. PMID: 41294276, DOI: 10.1002/mp.70173.Peer-Reviewed Original ResearchMulti-Institutional Verification of a Novel Predictor (Volume-Scaled SUVmax) for Successful Biology-Guided Radiotherapy Delivery of Small Targets
Ashraf M, Pham D, Bal G, Chen H, Park H, Watkins T, Cai B, Badiyan S, Vitzthum L, Loo B, Surucu M. Multi-Institutional Verification of a Novel Predictor (Volume-Scaled SUVmax) for Successful Biology-Guided Radiotherapy Delivery of Small Targets. Cancers 2025, 17: 3645. PMID: 41301012, PMCID: PMC12651831, DOI: 10.3390/cancers17223645.Peer-Reviewed Original ResearchGamma passing ratesBiology-guided radiotherapySiemens Biograph mCTActivity concentrationsDelivery accuracyTarget-to-background ratioConsistent with current recommendationsBgRTSpherical targetTarget sizeBiograph mCTPass rateSUVmax valuesSUVmaxTreatment eligibilityEligibility RecommendationsAC measurementsCurrent recommendationsDiagnostic PETRetrospective dataNovel predictorsPatient dataSuccessful deliveryArcCHECKHigher thresholdsInnovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy
Yan Y, Alexander D, Bednarz B, Bronk L, Chen H, Gladstone D, Han B, Iannuzzi C, Li Y, Nguyen N, Mulenga N, Viscariello N, Wang Y, Weygand J, Zlateva Y, Guan F. Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy. Frontiers In Medicine 2025, 12: 1686593. PMID: 41244760, PMCID: PMC12613237, DOI: 10.3389/fmed.2025.1686593.Peer-Reviewed Original ResearchProton computed tomographyOnline plan adaptationPrecision radiation oncologyRadiation oncologyCone beam computed tomography systemSoft tissue visualizationRadiotherapy systemRadiopharmaceutical dosimetryDose deliveryProton therapyComputed tomographyMetabolically active tumor regionsMedical physicistsPrecision radiotherapyQuality assurance protocolsRadiation therapy approachesComputed tomography systemDual-energy computed tomographyPlan adaptationActive tumor regionsAdaptive workflowDual-energyRadiation imagingRadiation therapyIntegration of multi-omicsFirst-in-Human dual modality radiotherapy treatment in a single plan using Biology-guided radiotherapy: A case report
Park HS, Chen H, Draeger E, Tressel L, Kim JJ, Johung KL, Young MR, AL Feghali KA, Jong DD, Chen ZJ, Carlson DJ. International Journal of Radiation Oncology. Biology. Physics. 2025 September; 123(1S): S122Peer-Reviewed Original Research18F-FDG PET image metric analysis of clinical patients treated using biological guided radiotheerapy (BgRT)
Chen H, Park HS, Bal G, Tressel L, Kim JJ, Draeger E, Han D, Hill V, Longo D, Jasman AT, Burke M, Shulman A, Chen ZJ, Carlson DJ. International Journal of Radiation Oncology. Biology. Physics. 2025 September; 123(1S): S251Peer-Reviewed Original ResearchCharacterizing and Modeling Higher-Order Motions of Collimator Subsystem on a 60RPM Gantry Linac for Improved Small Target Dosimetry
Chen H, Yang R, Gaderlund B, Chang Y, Carlson DJ, Chen ZJ. Journal of Medical Physics. 2025 September; 52(10): WE-305-209Peer-Reviewed Original ResearchPosition emission tomography-guided radiation therapy: An overview of the RefleXion SCINTIX biology-guided platform
Han DY, Chen H, Zhong W, Lee M, Park HS, Chang Y, Chen ZJ, Carlson DJ. Journal of Radiosurgery and SBRT. 2025 MayPeer-Reviewed Original ResearchMeasurements of small field output correction factors on a RefleXion treatment machine
Zhong W, Chen ZJ, Lee M, Guan F, Chen H, Han DY. Precision Radiation Oncology. 2025 MarchPeer-Reviewed Original Research
2024
Evaluation of 18F-FDG and 18F-FMISO PET Imaging for Biologically Guided Radiotherapy in Lung and Abdomen Cancer Patients
Draeger E, Chen H, Kim JJ, Tressel L, Hicks DF, Liu Q, Liu C, Bal G, Park HS, Chen Z, Carlson DJ. International Journal of Radiation Oncology. Biology. Physics. 2024, October; 120(2S): S118-119Peer-Reviewed Original ResearchImpact of Synthetic PET Evaluation prior to PET-Guided Functional Modeling in Optimizing Patient Selection for Biology-Guided Radiotherapy
Hicks D, Chen H, Kim J, Tressel L, Wallington D, Becht K, Johung K, Young M, Feghali K, Jong D, Chen Z, Carlson D, Park HSPeer-Reviewed Original Research