2022
Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response
Hu Q, Xu T, Zhang M, Zhang H, Liu Y, Li H, Chen C, Zheng J, Zhang Z, Li F, Shen N, Zhang W, Melnick A, Huang C. Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response. Cell Reports 2022, 40: 111035. PMID: 35793628, PMCID: PMC9550188, DOI: 10.1016/j.celrep.2022.111035.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBasic-Leucine Zipper Transcription FactorsCell DifferentiationGerminal CenterRNATranscription FactorsConceptsBach2 proteinCell fateActivated B cellsMemory B cellsB cellsCell fate choiceDetermines cell fateCell fate outcomesRapamycin complex 1B cell fateEffector cellsGerminal centre B cell fatePivotal transcription factorB cell receptor affinityEarly B cell responsesTranscription factorsDependent translationB cell responsesPrimary humoral responseGC fateMechanistic targetHumoral responseProteinPlasma cellsDifferential dynamics
2018
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications 2018, 9: 3157. PMID: 30089837, PMCID: PMC6082899, DOI: 10.1038/s41467-018-05676-6.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAntineoplastic AgentsAutoimmunityBasic-Leucine Zipper Transcription FactorsBone Marrow CellsCD4-Positive T-LymphocytesCell DifferentiationCell Line, TumorCell NucleusCysteine EndopeptidasesFemaleGene DeletionGene Expression ProfilingGene Expression RegulationHEK293 CellsHomeostasisHumansImmune ToleranceLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutPeptide HydrolasesReactive Oxygen SpeciesSumoylationT-Lymphocytes, RegulatoryConceptsRegulatory T cellsTreg cellsT cellsReactive oxygen speciesSUMO-specific protease 3T effector cell differentiationAntitumor T-cell responsesTreg cell-specific deletionT cell responsesEffector cell differentiationTreg cell stabilityCell-specific deletionT cell activationImmune toleranceTumor immunosuppressionAutoimmune symptomsImmune homeostasisRegulation of ROSRole of SENP3Cell activationCell responsesGene signatureProtease 3Pivotal regulatorNuclear export