2021
Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
Tortolero G, Brown M, Sharma S, de Oliveira Otto M, Yamal J, Aguilar D, Gunther M, Mofleh D, Harris R, John J, de Vries P, Ramphul R, Serbo D, Kiger J, Banerjee D, Bonvino N, Merchant A, Clifford W, Mikhail J, Xu H, Murphy R, Wei Q, Vahidy F, Morrison A, Boerwinkle E. Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality. PLOS ONE 2021, 16: e0247235. PMID: 34081724, PMCID: PMC8174716, DOI: 10.1371/journal.pone.0247235.Peer-Reviewed Original ResearchConceptsBody mass indexCOVID-19 patientsRisk factorsTobacco useCOVID-19 fatalitiesHealth information exchangeRace/ethnicityCOVID-19Laboratory risk factorsNumber of comorbiditiesCOVID-19 cohortMultivariable logistic regressionImportant risk factorPotential risk factorsCOVID-19 outcomesFormer tobacco usersTobacco use historyLarge health information exchangeMass indexElectronic health record systemsUnfavorable outcomeClinical dataTobacco usersOutcome analysisElectronic health information
2015
Trends and variations in breast and colorectal cancer incidence from 1995 to 2011: A comparative study between Texas Cancer Registry and National Cancer Institute’s Surveillance, Epidemiology and End Results data
LIU Z, ZHANG Y, FRANZIN L, CORMIER J, CHAN W, XU H, DU X. Trends and variations in breast and colorectal cancer incidence from 1995 to 2011: A comparative study between Texas Cancer Registry and National Cancer Institute’s Surveillance, Epidemiology and End Results data. International Journal Of Oncology 2015, 46: 1819-1826. PMID: 25672365, PMCID: PMC4356494, DOI: 10.3892/ijo.2015.2881.Peer-Reviewed Original ResearchConceptsColorectal cancer incidenceNational Cancer Institute's SurveillanceTexas Cancer RegistryBreast cancer incidenceCancer incidenceCancer RegistryAge-adjusted breast cancer incidenceColorectal cancer patientsEnd Results (SEER) dataSEER areasColorectal cancerCancer patientsIncidence rateRelative riskIncidenceBreastRegistrySurveillanceEpidemiologySEERResult dataTemporal trendsEnd resultPatientsParallel comparison
2013
Opioid Use After Cardiac Surgery in Children With Down Syndrome*
Van Driest S, Shah A, Marshall M, Xu H, Smith A, McGregor T, Kannankeril J. Opioid Use After Cardiac Surgery in Children With Down Syndrome*. Pediatric Critical Care Medicine 2013, 14: 862-868. PMID: 23962833, PMCID: PMC3830692, DOI: 10.1097/pcc.0b013e31829f5d9d.Peer-Reviewed Original ResearchConceptsCardiac bypass timeCumulative opioid dosesOpioid dosesCardiac surgeryDown syndromeOpioid doseBypass timePeak serum creatinine valuesRetrospective observational comparative studyNonsteroidal anti-inflammatory drugsElectronic medical record dataAdditional operative proceduresLonger hospital staySerum creatinine valuesObservational comparative studyPediatric teaching hospitalNeuromuscular blocking agentsMedical record dataAnti-inflammatory drugsOpioid resistanceHospital stayOpioid exposureOpioid medicationsPain scoresLonger hospitalization
2012
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients
Birdwell K, Grady B, Choi L, Xu H, Bian A, Denny J, Jiang M, Vranic G, Basford M, Cowan J, Richardson D, Robinson M, Ikizler T, Ritchie M, Stein C, Haas D. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenetics And Genomics 2012, 22: 32-42. PMID: 22108237, PMCID: PMC3237759, DOI: 10.1097/fpc.0b013e32834e1641.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Body WeightCytochrome P-450 CYP3ADatabases, Nucleic AcidDose-Response Relationship, DrugDrug MonitoringElectronic Health RecordsFemaleGenetic Association StudiesGenotypeHemoglobinsHumansImmunosuppressive AgentsKidney TransplantationLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePregnane X ReceptorReceptors, SteroidTacrolimusConceptsTacrolimus dose requirementsKidney transplant recipientsDose requirementsElectronic medical recordsBlood concentrationsTransplant recipientsMedical recordsCYP3A5 rs776746Electronic medical record dataInterindividual pharmacokinetic variabilityTacrolimus blood concentrationsNarrow therapeutic indexDNA biobanksMedical record dataTherapeutic drug monitoringDrug-metabolizing enzymesKidney transplantationClinical factorsPrimary outcomeImmunosuppressive drugsPharmacokinetic variabilityTacrolimus clearanceClinical covariatesPharmacogenomic predictorsTherapeutic index