2022
Recurrent neural network models (CovRNN) for predicting outcomes of patients with COVID-19 on admission to hospital: model development and validation using electronic health record data
Rasmy L, Nigo M, Kannadath B, Xie Z, Mao B, Patel K, Zhou Y, Zhang W, Ross A, Xu H, Zhi D. Recurrent neural network models (CovRNN) for predicting outcomes of patients with COVID-19 on admission to hospital: model development and validation using electronic health record data. The Lancet Digital Health 2022, 4: e415-e425. PMID: 35466079, PMCID: PMC9023005, DOI: 10.1016/s2589-7500(22)00049-8.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Electronic Health RecordsHospitalsHumansNeural Networks, ComputerRetrospective StudiesConceptsLight Gradient Boost MachineFeature engineeringGradient-boosting machineMultiple machine learning modelsElectronic health record dataNeural network-based modelReal-world datasetsRecurrent neural network modelComplex feature engineeringMachine learning modelsBinary classification taskSpecific feature selectionLogistic regression algorithmNeural network modelHealth record dataRecurrent neural network-based modelBinary classification modelNetwork-based modelTraditional machineExtensive data preprocessingHigh prediction accuracyMultiple external datasetsClassification taskData preprocessingFeature selection
2021
A Discrete Joint Model for Entity and Relation Extraction from Clinical Notes.
Ji Z, Ghiasvand O, Wu S, Xu H. A Discrete Joint Model for Entity and Relation Extraction from Clinical Notes. AMIA Joint Summits On Translational Science Proceedings 2021, 2021: 315-324. PMID: 34457146, PMCID: PMC8378610.Peer-Reviewed Original ResearchConceptsRelation classificationPipeline architectureClinical natural language processingNatural language processingEntity recognitionBeam searchRelation extractionClinical notesLanguage processingClassification stepEntity pairsStructured perceptronFundamental taskClinical narrativesTraditional solutionsRecognition stepError propagationArchitectureJoint modelTaskSubtasksPerceptronClinical conceptsEntitiesClassification
2020
Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study
Xiang Y, Ji H, Zhou Y, Li F, Du J, Rasmy L, Wu S, Zheng W, Xu H, Zhi D, Zhang Y, Tao C. Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study. Journal Of Medical Internet Research 2020, 22: e16981. PMID: 32735224, PMCID: PMC7428917, DOI: 10.2196/16981.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaDeep LearningDisease ProgressionFemaleHumansMaleNeural Networks, ComputerQuality of LifeRetrospective StudiesRisk AssessmentRisk FactorsConceptsAttentive Neural NetworkAsthma exacerbationsRisk factorsNeural networkAdvanced deep learning modelsClinical variablesDeep learning modelsCerner Health Facts databaseLarge electronic health recordNeural network modelRetrospective cohort studyHealth Facts databasePotential risk factorsRisk factor analysisPersonalized risk factorsElectronic health recordsBaseline methodsLearning modelPersonalized risk scoreProgressive asthmaAsthma symptomsEsophageal refluxAdult patientsCohort studyTime-SensitiveA study of entity-linking methods for normalizing Chinese diagnosis and procedure terms to ICD codes
Wang Q, Ji Z, Wang J, Wu S, Lin W, Li W, Ke L, Xiao G, Jiang Q, Xu H, Zhou Y. A study of entity-linking methods for normalizing Chinese diagnosis and procedure terms to ICD codes. Journal Of Biomedical Informatics 2020, 105: 103418. PMID: 32298846, DOI: 10.1016/j.jbi.2020.103418.Peer-Reviewed Original ResearchMeSH KeywordsChinaClinical CodingInternational Classification of DiseasesNeural Networks, ComputerSupport Vector MachineConceptsBM25 algorithmConcept rankingConcept generationConvolutional neural network approachNeural network approachRanking-based methodRanking methodSupport vector machineProcedure termsBetter performanceVector machineDifferent algorithmsMedical codingNetwork approachAlgorithmICD codesBERTExtended versionGood accuracyKnowledgebaseDisease termsClinical termsMatch criteriaCodeChinese diagnosis
2019
Enhancing clinical concept extraction with contextual embeddings
Si Y, Wang J, Xu H, Roberts K. Enhancing clinical concept extraction with contextual embeddings. Journal Of The American Medical Informatics Association 2019, 26: 1297-1304. PMID: 31265066, PMCID: PMC6798561, DOI: 10.1093/jamia/ocz096.Peer-Reviewed Original ResearchMeSH KeywordsBig DataDatabases, FactualHumansInformation Storage and RetrievalNatural Language ProcessingNeural Networks, ComputerPublic Reporting of Healthcare DataConceptsClinical concept extractionContextual embeddingsNatural language processing tasksTraditional word embeddingsTraditional word representationsClinical NLP tasksLanguage processing tasksSemantic informationWord embedding methodsLarge language modelsArt performanceConcept extraction taskSemEval 2014Word representationsNLP tasksLanguage modelWord embeddingsProcessing tasksNeural network-based representationI2b2 2010Concept extractionTaskLarge clinical corpusClinical corpusNetwork-based representationTemporal indexing of medical entity in Chinese clinical notes
Liu Z, Wang X, Chen Q, Tang B, Xu H. Temporal indexing of medical entity in Chinese clinical notes. BMC Medical Informatics And Decision Making 2019, 19: 17. PMID: 30700331, PMCID: PMC6354334, DOI: 10.1186/s12911-019-0735-x.Peer-Reviewed Original ResearchMeSH KeywordsChinaData MiningElectronic Health RecordsHumansMedical Informatics ApplicationsNeural Networks, ComputerTime FactorsConceptsSupport vector machineConvolutional neural networkTemporal indexingNeural network modelIndexing taskRelation classificationMedical entitiesRecurrent convolutional neural network modelMachine learning-based systemsConvolutional neural network modelDeep neural network modelNetwork methodNetwork modelLearning-based systemTemporal relation classificationRecurrent neural network methodChinese clinical notesTemporal relationsClinical notesNeural network methodI2b2 NLP challengeContext informationTime indexingSemantic informationBaseline methods
2018
Combine Factual Medical Knowledge and Distributed Word Representation to Improve Clinical Named Entity Recognition.
Wu Y, Yang X, Bian J, Guo Y, Xu H, Hogan W. Combine Factual Medical Knowledge and Distributed Word Representation to Improve Clinical Named Entity Recognition. AMIA Annual Symposium Proceedings 2018, 2018: 1110-1117. PMID: 30815153, PMCID: PMC6371322.Peer-Reviewed Original ResearchMeSH KeywordsDeep LearningHumansNatural Language ProcessingNeural Networks, ComputerUnified Medical Language SystemConceptsRecurrent neural networkWord embeddingsOne-hot vectorsWord representationsLow-frequency wordsOnly word embeddingsClinical Named Entity RecognitionClinical NER tasksWord embedding methodsConditional Random FieldsStatistical language modelNamed Entity RecognitionUnlabeled corpusLanguage modelLanguage systemNER taskDecent representationFactual medical knowledgeImportant wordsDeep learning modelsEntity recognitionClinical corpusNamed Entity Recognition SystemArt performanceFeature representationExtracting psychiatric stressors for suicide from social media using deep learning
Du J, Zhang Y, Luo J, Jia Y, Wei Q, Tao C, Xu H. Extracting psychiatric stressors for suicide from social media using deep learning. BMC Medical Informatics And Decision Making 2018, 18: 43. PMID: 30066665, PMCID: PMC6069295, DOI: 10.1186/s12911-018-0632-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDeep LearningHumansNeural Networks, ComputerSocial MediaStress, PsychologicalSuicide PreventionConceptsConvolutional neural networkRecurrent neural networkDeep learningConditional Random FieldsSupport vector machineSuicide-related tweetsClinical textNeural networkPsychiatric stressorsExtra TreesBinary classifierTransfer learning strategiesEntity recognition taskSocial mediaExact matchTraditional machineAnnotation costLearning strategiesRecognition problemSharing flowInexact matchVector machineTwitter dataRecognition taskTwitterA study of generalizability of recurrent neural network-based predictive models for heart failure onset risk using a large and heterogeneous EHR data set
Rasmy L, Wu Y, Wang N, Geng X, Zheng W, Wang F, Wu H, Xu H, Zhi D. A study of generalizability of recurrent neural network-based predictive models for heart failure onset risk using a large and heterogeneous EHR data set. Journal Of Biomedical Informatics 2018, 84: 11-16. PMID: 29908902, PMCID: PMC6076336, DOI: 10.1016/j.jbi.2018.06.011.Peer-Reviewed Original ResearchConceptsRecurrent neural networkOnset riskCapability of RNNCerner Health FactsHeterogeneous EHR dataHeart failure patientsData setsElectronic health record dataDeep learning modelsDifferent patient populationsNeural network-based predictive modelDifferent patient groupsHealth record dataEHR data setsPredictive modelingSmall data setsFailure patientsPatient groupPatient populationReduction of AUCNeural networkRNN modelRETAIN modelHealth FactsHospitalClinical Named Entity Recognition Using Deep Learning Models.
Wu Y, Jiang M, Xu J, Zhi D, Xu H. Clinical Named Entity Recognition Using Deep Learning Models. AMIA Annual Symposium Proceedings 2018, 2017: 1812-1819. PMID: 29854252, PMCID: PMC5977567.Peer-Reviewed Original ResearchMeSH KeywordsDatasets as TopicDeep LearningMedical RecordsNatural Language ProcessingNeural Networks, ComputerConceptsClinical Named Entity RecognitionNamed Entity RecognitionDeep learning modelsConvolutional neural networkClinical NER systemRecurrent neural networkNeural networkLearning modelEntity recognitionRNN modelNER systemDeep neural network architecturePopular deep learning architecturesNatural language processing tasksUnsupervised learning featuresConditional random field modelAutomatic feature learningDeep learning architectureClinical NER tasksDeep neural networksNeural network architectureClinical concept extractionLanguage processing tasksFeature learningLearning architecture
2017
CNN-based ranking for biomedical entity normalization
Li H, Chen Q, Tang B, Wang X, Xu H, Wang B, Huang D. CNN-based ranking for biomedical entity normalization. BMC Bioinformatics 2017, 18: 385. PMID: 28984180, PMCID: PMC5629610, DOI: 10.1186/s12859-017-1805-7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiomedical ResearchDatabases as TopicHumansNeural Networks, ComputerReference StandardsSemanticsConceptsBiomedical entity normalizationEntity normalizationSemantic informationCNN architectureNovel convolutional neural network architectureConvolutional neural network architectureTraditional rule-based methodsNeural network architectureRule-based systemRanking methodRule-based methodNetwork architectureBiomedical entitiesBenchmark datasetsArt performanceEntity mentionsRanking problemCNNNormalization systemArchitectureMorphological informationComparison resultsInformationDatasetSystemEntity recognition from clinical texts via recurrent neural network
Liu Z, Yang M, Wang X, Chen Q, Tang B, Wang Z, Xu H. Entity recognition from clinical texts via recurrent neural network. BMC Medical Informatics And Decision Making 2017, 17: 67. PMID: 28699566, PMCID: PMC5506598, DOI: 10.1186/s12911-017-0468-7.Peer-Reviewed Original ResearchMeSH KeywordsElectronic Health RecordsHumansMachine LearningMedical InformaticsNatural Language ProcessingNeural Networks, ComputerConceptsRecurrent neural networkNatural language processingEntity recognitionClinical textTraditional machineNeural networkClinical natural language processingMedical concept extractionHand-crafted featuresClinical entity recognitionDeep learning methodsClinical event detectionConditional Random FieldsSupport vector machineI2b2 NLP challengePerformance of LSTMTypes of entitiesClinical domainsContext informationFeature engineeringConcept extractionDe-identificationEvent detectionKnowledge basesLSTM layers
2015
Named Entity Recognition in Chinese Clinical Text Using Deep Neural Network.
Wu Y, Jiang M, Lei J, Xu H. Named Entity Recognition in Chinese Clinical Text Using Deep Neural Network. 2015, 216: 624-8. PMID: 26262126, PMCID: PMC4624324.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiological OntologiesChinaData MiningElectronic Health RecordsLanguageMachine LearningNeural Networks, ComputerTerminology as TopicVocabulary, ControlledConceptsDeep neural networksLarge unlabeled corpusNamed Entity RecognitionWord embeddingsUnlabeled corpusUnsupervised learningEntity recognitionNeural networkNatural language processing technologyNovel deep learning methodLanguage processing technologyDeep learning methodsUnsupervised feature learningFeature engineering approachImportant healthcare informationChinese clinical textTypes of entitiesFeature learningNER taskClinical textLearning methodsClinical documentsCRF modelHealthcare informationFree text