2012
Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping
Schildcrout J, Denny J, Bowton E, Gregg W, Pulley J, Basford M, Cowan J, Xu H, Ramirez A, Crawford D, Ritchie M, Peterson J, Masys D, Wilke R, Roden D. Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping. Clinical Pharmacology & Therapeutics 2012, 92: 235-242. PMID: 22739144, PMCID: PMC3785311, DOI: 10.1038/clpt.2012.66.Peer-Reviewed Original ResearchConceptsVanderbilt University Medical CenterAdverse eventsPreemptive genotypingPotential adverse eventsUniversity Medical CenterHome patientsPharmacogenetic associationsMedical CenterVariant allelesMedicationsDrug outcomesPatient safetyDrug decision makingRelevant genetic variantsRoutine integrationTarget drugsGenetic variantsOutcomesFrequency of opportunitiesGenotypingSafetyPrescribingPatientsCohortPharmacogeneticsElectronic Medical Records as a Tool in Clinical Pharmacology: Opportunities and Challenges
Roden D, Xu H, Denny J, Wilke R. Electronic Medical Records as a Tool in Clinical Pharmacology: Opportunities and Challenges. Clinical Pharmacology & Therapeutics 2012, 91: 1083-1086. PMID: 22534870, PMCID: PMC3819803, DOI: 10.1038/clpt.2012.42.Peer-Reviewed Original ResearchMeSH KeywordsElectronic Health RecordsGeneticsHumansPharmacogeneticsPharmacology, ClinicalPhenotypeUnited States
2011
Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record
Delaney J, Ramirez A, Bowton E, Pulley J, Basford M, Schildcrout J, Shi Y, Zink R, Oetjens M, Xu H, Cleator J, Jahangir E, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record. Clinical Pharmacology & Therapeutics 2011, 91: 257-263. PMID: 22190063, PMCID: PMC3621954, DOI: 10.1038/clpt.2011.221.Peer-Reviewed Original ResearchMeSH KeywordsAgedAryl Hydrocarbon HydroxylasesAryldialkylphosphataseATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ClopidogrelCytochrome P-450 CYP2C19Databases, Nucleic AcidElectronic Health RecordsFemaleGenotypeHumansMaleMyocardial InfarctionPharmacogeneticsPlatelet Aggregation InhibitorsPolymorphism, GeneticStentsThrombosisTiclopidineTreatment OutcomeConceptsPercutaneous coronary interventionElectronic health recordsCardiac eventsMyocardial infarctionRecurrent cardiac eventsRecurrent cardiovascular eventsHealth recordsUse of EHRsClopidogrel therapyCardiovascular eventsClopidogrel treatmentClopidogrel resistanceClopidogrel responseCoronary interventionStent thrombosisReal-world settingCYP2C19ABCB1PON1Pharmacogenomic studiesRecurrent eventsTreatmentDNA repositoryDNA samplesInfarctionRANKING GENE-DRUG RELATIONSHIPS IN BIOMEDICAL LITERATURE USING LATENT DIRICHLET ALLOCATION
Altman R, Dunker A, Hunter L, Murray T, Klein T, WU Y, LIU M, ZHENG W, ZHAO Z, XU H. RANKING GENE-DRUG RELATIONSHIPS IN BIOMEDICAL LITERATURE USING LATENT DIRICHLET ALLOCATION. Biocomputing 2011, 422-33. PMID: 22174297, PMCID: PMC4095990, DOI: 10.1142/9789814366496_0041.Peer-Reviewed Original ResearchFacilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
Xu H, Jiang M, Oetjens M, Bowton E, Ramirez A, Jeff J, Basford M, Pulley J, Cowan J, Wang X, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal Of The American Medical Informatics Association 2011, 18: 387-391. PMID: 21672908, PMCID: PMC3128409, DOI: 10.1136/amiajnl-2011-000208.Peer-Reviewed Original ResearchAlgorithmsAnticoagulantsAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C9Data MiningDatabases, Nucleic AcidDrug Dosage CalculationsElectronic Health RecordsGenome-Wide Association StudyHumansLinear ModelsMixed Function OxygenasesNatural Language ProcessingPharmacogeneticsPrecision MedicineUnited StatesVitamin K Epoxide ReductasesWarfarinThe Emerging Role of Electronic Medical Records in Pharmacogenomics
Wilke R, Xu H, Denny J, Roden D, Krauss R, McCarty C, Davis R, Skaar T, Lamba J, Savova G. The Emerging Role of Electronic Medical Records in Pharmacogenomics. Clinical Pharmacology & Therapeutics 2011, 89: 379-386. PMID: 21248726, PMCID: PMC3204342, DOI: 10.1038/clpt.2010.260.Peer-Reviewed Original Research