2024
A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis
Pavličev M, McDonough-Goldstein C, Zupan A, Muglia L, Hu Y, Kong F, Monangi N, Dagdas G, Zupančič N, Maziarz J, Sinner D, Zhang G, Wagner G, Muglia L. A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis. Nature Communications 2024, 15: 1152. PMID: 38346980, PMCID: PMC10861470, DOI: 10.1038/s41467-024-45338-4.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsEndometriosisEndometriumEstrogensFemaleHumansMiceNeoplasmsPregnancyWnt4 ProteinConceptsFrequency of deleterious allelesAssociated with multiple phenotypesResistance to invasionWnt4 locusAlpha binding sitesPleiotropic mutationsDeleterious allelesPleiotropic SNPsMouse genomeMultiple phenotypesWnt4 transcriptionPopulation frequencyMolecular mechanismsPreovulatory estrogen peakRs3820282Estrogen-responsive tissuesWnt4 expressionCRISPR/Cas 9AllelesTranscriptionEndometriotic fociEndometrial stromaMutationsEpithelial proliferationEstrogen peak
2020
Transcriptomic responses to hypoxia in endometrial and decidual stromal cells
Rytkönen KT, Heinosalo T, Mahmoudian M, Ma X, Perheentupa A, Elo LL, Poutanen M, Wagner G. Transcriptomic responses to hypoxia in endometrial and decidual stromal cells. Reproduction 2020, 160: 39-51. PMID: 32272449, DOI: 10.1530/rep-19-0615.Peer-Reviewed Original ResearchConceptsDecidual stromal cellsEndometrial stromal fibroblastsEndometriotic stromal cellsStromal cellsInflammatory transcription factorsEpithelial-mesenchymal transitionExpression of JunDCEBP transcription factorsCell typesHealthy endometriumEndometriosis lesionsProgesterone receptorDecidualization processUterine endometriumStromal fibroblastsMesenchymal transitionProgesterone signalingEndometriumHypoxiaHypoxia pathwayTranscription factorsHuman reproductive successDistinct transcriptional statesExpression of genesJun/Fos