2024
Reading the palimpsest of cell interactions: What questions may we ask of the data?
Pavlicev M, Wagner G. Reading the palimpsest of cell interactions: What questions may we ask of the data? IScience 2024, 27: 109670. PMID: 38665209, PMCID: PMC11043885, DOI: 10.1016/j.isci.2024.109670.Peer-Reviewed Original ResearchCompartmentalization of cellular processesStructure of interaction networksCell interactionsMulticellular organismsIntegrity of cellsCellular processesInteraction networkLevels of structural organizationBiological functionsBiological interpretationCell communicationInteraction dataStructural organizationWealth of dataCellsCoordination of functionsOrganizationHigher levels of structural organizationCompartmentalizationInteraction
2001
Epistasis and the Mutation Load: A Measurement-Theoretical Approach
Hansen T, Wagner G. Epistasis and the Mutation Load: A Measurement-Theoretical Approach. Genetics 2001, 158: 477-485. PMID: 11333254, PMCID: PMC1461645, DOI: 10.1093/genetics/158.1.477.Peer-Reviewed Original ResearchConceptsMutation-selection equilibriumGene interactionsEpistatic interactionsMutation loadStrength of epistasisMutation-selection balanceGenomic mutation rateHigher-order gene interactionsSynergistic epistasisMean fitnessOptimal genotypeEpistatic effectsTwofold disadvantageEpistasisMutation rateGenetic backgroundSynergistic interactionSystematic relationshipGenesLociInteraction intensityInteractionFitnessInteraction densityGenotypesModeling Genetic Architecture: A Multilinear Theory of Gene Interaction
Hansen T, Wagner G. Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction. Theoretical Population Biology 2001, 59: 61-86. PMID: 11243929, DOI: 10.1006/tpbi.2000.1508.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapGene interactionsQuantitative genetic variationEffects of epistasisGenetic canalizationGenetic experimentsGenetic variationGene substitutionGenetic backgroundEpistasisTractable modelComplex functionsCentral importanceLociBiologyCanalizationPhenotypeGenotypesInteractionSum of linear