2008
Pleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
1999
Evolution of Chordate Hox Gene Clustersa
RUDDLE F, AMEMIYA C, CARR J, KIM C, LEDJE C, SHASHIKANT C, WAGNER G. Evolution of Chordate Hox Gene Clustersa. Annals Of The New York Academy Of Sciences 1999, 870: 238-248. PMID: 10415487, DOI: 10.1111/j.1749-6632.1999.tb08884.x.Peer-Reviewed Original ResearchConceptsHox cluster duplicationsCluster duplicationBody plan evolutionTerms of genomeGene duplicationHox genesDevelopmental evolutionGene enhancerDuplication modelDuplicationVertebratesNew functionsChordatesInvertebratesGenomeImportant roleEvolutionUrogenital systemGenesEnhancerRoleDaughter clustersNeuromuscular interactionNovel features
1996
PCR‐survey of hox‐genes of the zebrafish: New sequence information and evolutionary implications
Misof B, Blanco M, Wagner G. PCR‐survey of hox‐genes of the zebrafish: New sequence information and evolutionary implications. Journal Of Experimental Zoology 1996, 274: 193-206. PMID: 8882497, DOI: 10.1002/(sici)1097-010x(19960215)274:3<193::aid-jez6>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsHox gene complementGene complementPCR surveyHox gene sequencesZebrafish Danio rerioNumber of genesNew sequence informationInsufficient sequence variationZebrafish genesHox genesPutative genesEvolutionary implicationsBony fishDanio rerioHuman genomeGene sequencesSequence variationSequence informationCognate groupsGenesType sequenceSequenceGenomeRerioFragments