2021
Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups
Groot C, Grothe MJ, Mukherjee S, Jelistratova I, Jansen I, van Loenhoud AC, Risacher SL, Saykin AJ, Mac Donald C, Mez J, Trittschuh EH, Gryglewski G, Lanzenberger R, Pijnenburg YAL, Barkhof F, Scheltens P, van der Flier WM, Crane PK, Ossenkoppele R. Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups. NeuroImage Clinical 2021, 30: 102660. PMID: 33895633, PMCID: PMC8186562, DOI: 10.1016/j.nicl.2021.102660.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesBrainFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsTranscriptomeConceptsGray matter volumeRegional GM volumeAd memoryAd executivesGM volumeMatter volumeRegional gray matter volumeVoxel-wise contrastsAlzheimer’s disease subgroupsCognitive domainsCognitive profileNeuropsychological assessmentNeurobiological mechanismsNeurobiological differencesPsychometric frameworkAd languageRelative impairmentTemporal lobeHuman brainAllen Human Brain AtlasDifferential patternsStructural MRILower GM volumeHuman Brain AtlasPosterior areas
2017
Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity
Hahn A, Gryglewski G, Nics L, Rischka L, Ganger S, Sigurdardottir H, Vraka C, Silberbauer L, Vanicek T, Kautzky A, Wadsak W, Mitterhauser M, Hartenbach M, Hacker M, Kasper S, Lanzenberger R. Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity. Brain Structure And Function 2017, 223: 1369-1378. PMID: 29134288, PMCID: PMC5869947, DOI: 10.1007/s00429-017-1558-0.Peer-Reviewed Original ResearchConceptsTask performanceBrain networksFunctional connectivityTask-relevant brain networksBrain regionsSimple task performanceDefault mode networkHuman brain functionResting-state networksTask-specific changesCognitive tasksMode networkFunctional MRICertain brain regionsWhite matter microstructureEntire brain networkGlucose metabolismRecent methodological advancementsBrain functionTaskYields important insightsCertain tasksRight fingerMethodological advancementsMotor cortex