2021
Comparison and Reliability of Hippocampal Subfield Segmentations Within FreeSurfer Utilizing T1- and T2-Weighted Multispectral MRI Data
Seiger R, Hammerle FP, Godbersen GM, Reed MB, Spurny-Dworak B, Handschuh P, Klöbl M, Unterholzner J, Gryglewski G, Vanicek T, Lanzenberger R. Comparison and Reliability of Hippocampal Subfield Segmentations Within FreeSurfer Utilizing T1- and T2-Weighted Multispectral MRI Data. Frontiers In Neuroscience 2021, 15: 666000. PMID: 34602964, PMCID: PMC8480394, DOI: 10.3389/fnins.2021.666000.Peer-Reviewed Original ResearchHigh-resolution T2-weighted sequencesProcessing pipelineT2-weighted sequencesAccurate segmentationMultispectral informationMultispectral MRI dataPutative imaging biomarkersDifferent processing pipelinesStructural MRI sequencesT1-weighted sequencesTest-retest variabilityDifferent input configurationsCross-sectional mannerInput imageSegmentation resultsDisease progressionMagnetic resonance imaging dataHippocampal fissureHippocampal formationHippocampal subfieldsHippocampal subfield segmentationPatient stratificationBrain areasPsychiatric diseasesDice coefficientMeta-analysis of brain structural changes after electroconvulsive therapy in depression
Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P. Meta-analysis of brain structural changes after electroconvulsive therapy in depression. Brain Stimulation 2021, 14: 927-937. PMID: 34119669, DOI: 10.1016/j.brs.2021.05.014.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyDentate gyrusHippocampal subfieldsSignificant volume increaseSeries of ECTStandardized mean change scoresBrain structuresLongitudinal magnetic resonance imagingBrain structural changesCornu ammonis 1Mean change scoresRegional brain volumesRandom-effects modelMagnetic resonance imagingClinical outcomesSymptom improvementDepressive patientsTreatment outcomesStandardized mean changeBilateral hippocampusIndividual patientsMean changeBrain volumeWarrant replicationResonance imaging
2019
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study
Kraus C, Seiger R, Pfabigan D, Sladky R, Tik M, Paul K, Woletz M, Gryglewski G, Vanicek T, Komorowski A, Kasper S, Lamm C, Windischberger C, Lanzenberger R. Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study. The International Journal Of Neuropsychopharmacology 2019, 22: 513-522. PMID: 31175352, PMCID: PMC6672627, DOI: 10.1093/ijnp/pyz030.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAntidepressive Agents, Second-GenerationAustriaCitalopramDepressive Disorder, MajorDrug SubstitutionFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsRemission InductionSelective Serotonin Reuptake InhibitorsSerotonin and Noradrenaline Reuptake InhibitorsTreatment OutcomeVenlafaxine HydrochlorideYoung AdultConceptsMajor depressive disorderDepressive disorderHippocampal subfieldsSubfield volumesAntidepressant treatmentHealthy controlsHippocampal-amygdaloid transition areaMajor depressive disorder patientsOpen-label studyMagnetic resonance imaging studyDepressive disorder patientsHippocampal formation volumeStructural magnetic resonance imagingHippocampal volume changesLower baseline volumesTreatment-related changesResonance imaging studyMagnetic resonance imagingMeasurement time pointsSerotonergic antidepressantsWeeks treatmentAcute patientsRight subiculumUnmedicated patientsBaseline volume
2018
Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis
Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klöbl M, Spurny B, Kautzky A, Vanicek T, Kasper S, Frey R, Lanzenberger R. Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis. The British Journal Of Psychiatry 2018, 214: 159-167. PMID: 30442205, PMCID: PMC6383756, DOI: 10.1192/bjp.2018.224.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyMagnetic resonance imagingCortical thicknessHippocampal subfieldsAmygdala nucleiHippocampal-amygdaloid transition areaRight unilateral electroconvulsive therapyEffects of ECTHigh-resolution structural magnetic resonance imagingUnipolar treatment-resistant depressionCorticoamygdaloid transition areaPathophysiology of depressionPre-post study designCorrelation of imagingUnilateral electroconvulsive therapyTreatment of choiceStructural magnetic resonance imagingSpecific hippocampal subfieldsSevere mental illnessGrant/research supportStress-related disordersClinical parametersRepeated-measures ANOVADentate gyrusSegmentation of hippocampal subfields and nuclei of the amygdala with major depressive disorder and healthy controls – preliminary findings
Vanicek T, Seiger R, Gryglewski G, Kautzky A, Klöbl M, Rischka L, Miles James G, S. Kranz G, Hahn A, Kasper S. Segmentation of hippocampal subfields and nuclei of the amygdala with major depressive disorder and healthy controls – preliminary findings. 2018 DOI: 10.26226/morressier.5b681762b56e9b005965c31f.Peer-Reviewed Original Research