2016
Polygenic risk of Alzheimer disease is associated with early- and late-life processes
Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Polygenic risk of Alzheimer disease is associated with early- and late-life processes. Neurology 2016, 87: 481-488. PMID: 27385740, PMCID: PMC4970660, DOI: 10.1212/wnl.0000000000002922.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsAtrophyBiomarkersCognition DisordersCohort StudiesEarly DiagnosisEthylene GlycolsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMaleMemory DisordersMultifactorial InheritancePolymorphism, Single NucleotidePositron-Emission TomographyYoung AdultConceptsHigher polygenic risk scorePolygenic risk scoresHippocampus volumeRisk scoreLarge observational cohort studyCommon genetic risk lociSmaller hippocampus volumesΒ-amyloid burdenObservational cohort studyGenetic riskElevated polygenic risk scoresAlzheimer's disease markersCSF β-amyloidLongitudinal cognitive declineHealthy young participantsCohort studyClinical progressionClinical symptomsAD dementiaAD markersSmaller hippocampiFlorbetapir PETAggregate genetic riskΒ-amyloidGenome-wide association studies
2015
Memory, executive, and multidomain subtle cognitive impairment
Toledo J, Bjerke M, Chen K, Rozycki M, Jack C, Weiner M, Arnold S, Reiman E, Davatzikos C, Shaw L, Trojanowski J, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Leon S, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Memory, executive, and multidomain subtle cognitive impairment. Neurology 2015, 85: 144-153. PMID: 26085606, PMCID: PMC4515043, DOI: 10.1212/wnl.0000000000001738.Peer-Reviewed Original ResearchConceptsCognitive impairmentAlzheimer's Disease Neuroimaging InitiativeDisease Neuroimaging InitiativeCSF Alzheimer's disease biomarkersDifferent clinical prognosesBiomarker signaturesAlzheimer's disease biomarkersCognitive impairment groupSubtle cognitive impairmentMemory complaint groupBrain atrophySingle ROISCI groupCN subjectsClinical prognosisHealthy controlsAtrophy patternsDementia stagesNeuroimaging biomarkersImpairment groupClinical cutoffComplaint groupPattern-based analysisADNI participantsSMC group
2010
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk D, Dickerson B, Weiner M, Aiello M, Aisen P, Albert M, Alexander G, Anderson H, Anderson K, Apostolova L, Arnold S, Ashford W, Assaly M, Asthana S, Bandy D, Bartha R, Bates V, Beckett L, Bell K, Benincasa A, Bergman H, Bernick C, Bernstein M, Black S, Blank K, Borrie M, Brand C, Brewer J, Brown A, Burns J, Cairns N, Caldwell C, Capote H, Carlsson C, Carmichael O, Cellar J, Celmins D, Chen K, Chertkow H, Chowdhury M, Clark D, Connor D, Correia S, Crawford K, Dale A, de Leon M, De Santi S, DeCarli C, deToledo-Morrell L, DeVous M, Diaz-Arrastia R, Dolen S, Donohue M, Doody R, Doraiswamy P, Duara R, Englert J, Farlow M, Feldman H, Felmlee J, Fleisher A, Fletcher E, Foroud T, Foster N, Fox N, Frank R, Gamst A, Given C, Graff-Radford N, Green R, Griffith R, Grossman H, Hake A, Hardy P, Harvey D, Heidebrink J, Hendin B, Herring S, Honig L, Hosein C, Hsiung G, Hudson L, Ismail M, Jack C, Jacobson S, Jagust W, Jayam-Trouth A, Johnson K, Johnson H, Johnson N, Johnson K, Johnson K, Johnson S, Kachaturian Z, Karlawish J, Kataki M, Kaye J, Kertesz A, Killiany R, Kittur S, Koeppe R, Korecka M, Kornak J, Kozauer N, Lah J, Laubinger M, Lee V, Lee T, Lerner A, Levey A, Longmire C, Lopez O, Lord J, Lu P, MacAvoy M, Malloy P, Marson D, Martin-Cook K, Martinez W, Marzloff G, Mathis C, Mc-Adams-Ortiz C, Mesulam M, Miller B, Mintun M, Mintzer J, Molchan S, Montine T, Morris J, Mulnard R, Munic D, Nair A, Neu S, Nguyen D, Norbash A, Oakley M, Obisesan T, Ogrocki P, Ott B, Parfitt F, Pawluczyk S, Pearlson G, Petersen R, Petrella J, Potkin S, Potter W, Preda A, Quinn J, Rainka M, Reeder S, Reiman E, Rentz D, Reynolds B, Richard J, Roberts P, Rogers J, Rosen A, Rosen H, Rusinek H, Sabbagh M, Sadowsky C, Salloway S, Santulli R, Saykin A, Scharre D, Schneider L, Schneider S, Schuff N, Shah R, Shaw L, Shen L, Silverman D, Simpson D, Sink K, Smith C, Snyder P, Spann B, Sperling R, Spicer K, Stefanovic B, Stern Y, Stopa E, Tang C, Tariot P, Taylor-Reinwald L, Thai G, Thomas R, Thompson P, Tinklenberg J, Toga A, Tremont G, Trojanowki J, Trost D, Turner R, van Dyck C, Vanderswag H, Varon D, Villanueva-Meyer J, Villena T, Walter S, Wang P, Watkins F, Weiner M, Williamson J, Wolk D, Wu C, Zerrate M, Zimmerman. E. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10256-10261. PMID: 20479234, PMCID: PMC2890481, DOI: 10.1073/pnas.1001412107.Peer-Reviewed Original ResearchConceptsMedial temporal lobe pathologyLarge-scale brain networksParticular cognitive domainsDomains of cognitionSpecific large-scale brain networksTemporal lobe pathologyDisease Neuroimaging InitiativeMild Alzheimer's diseaseExecutive controlLexical accessCognitive processesCognitive dissociationCognitive domainsDissociable effectsRegional cortical atrophyPoor memoryNeuroanatomic findingsPerformance deficitsMemory retentionBrain networksPotential confoundsCortical networksPsychometric testsRegional brain atrophyGreater impairment
1999
New insights on the neuroanatomy of schizophrenia
Pearlson G. New insights on the neuroanatomy of schizophrenia. Current Psychiatry Reports 1999, 1: 41-45. PMID: 11122904, DOI: 10.1007/s11920-999-0009-x.Peer-Reviewed Original ResearchMeSH KeywordsAnthropometryBrainGenotypeHumansLanguageMemory DisordersPhenotypeReceptors, NeurotransmitterSchizophrenia