2023
A data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Da Silva M, Melendez‐Torres G, Ismail Z, Testad I, Ballard C, Creese B, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Van der Swag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledoMorrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D'Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. A data‐driven examination of apathy and depressive symptoms in dementia with independent replication. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12398. PMID: 36777092, PMCID: PMC9899765, DOI: 10.1002/dad2.12398.Peer-Reviewed Original ResearchNeuropsychiatric symptomsDepressive symptomsLatent class analysisDifferent clinical associationsPoor clinical outcomeCommon neuropsychiatric symptomsApathy/depressionClinical outcomesClinical associationsIndependent cohortDepression syndromeDiagnostic criteriaClinical practiceApathy syndromeDepression symptomsSymptomsDiagnostic categoriesBiomarker studiesDepressionSyndromeLatent class membershipCohortFour-class solutionApathyData-driven examination
2020
O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS
Clementz B, Trotti R, Pearlson G, Keshavan M, Gershon E, Keedy S, Ivleva E, McDowell J, Tamminga C. O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS. Schizophrenia Bulletin 2020, 46: s7-s7. PMCID: PMC7234003, DOI: 10.1093/schbul/sbaa028.015.Peer-Reviewed Original ResearchClinical featuresPsychosis biotypesPsychosis casesPsychosis syndromeTreatment targetsSpecific treatment targetsB-SNIPClinical manifestationsBiomarker profilesPsychosis subgroupsB-SNIP consortiumDeep phenotyping approachPathophysiological mechanismsPsychosis patientsBipolar-Schizophrenia NetworkPsychosis diagnosisBiological subtypesHealthy personsClinical practiceClinical advancesNegative symptomsClinical phenomenologySyndrome
2014
P859: Differences in resting-state functional magnetic resonance imaging functional network connectivity between patients with restless legs syndrome and controls
Cho Y, Moon H, Lee Y, Chang H, Ku J, Pearlson G, Lee H. P859: Differences in resting-state functional magnetic resonance imaging functional network connectivity between patients with restless legs syndrome and controls. Clinical Neurophysiology 2014, 125: s272. DOI: 10.1016/s1388-2457(14)50892-9.Peer-Reviewed Original Research
2001
Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis
Kates W, Burnette C, Jabs E, Rutberg J, Murphy A, Grados M, Geraghty M, Kaufmann W, Pearlson G. Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biological Psychiatry 2001, 49: 677-684. PMID: 11313035, DOI: 10.1016/s0006-3223(00)01002-7.Peer-Reviewed Original ResearchConceptsWhite matter reductionLobar brain regionsVelocardiofacial syndromeWhite matterBrain regionsVolumetric MRI analysisWhite matter anomaliesWhite matter volumeMatter reductionCerebral lobesAxonal integrityPsychiatric disordersCardiac defectsMatter volumeSyndromeBrain tissueGray matterLobar volumesCSF compartmentMRI analysisBrain developmentCraniofacial anomaliesUnaffected childrenNeuropsychiatric phenotypesCoronal images
1997
Small planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measuresBasal ganglia volume in adults with Down syndrome
Aylward E, Li Q, Habbak R, Warren A, Pulsifer M, Barta P, Jerram M, Pearlson G. Basal ganglia volume in adults with Down syndrome. Psychiatry Research 1997, 74: 73-82. PMID: 9204510, DOI: 10.1016/s0925-4927(97)00011-5.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesGanglia volumesDS subjectsBasal gangliaDown syndromeControl subjectsDementia statusNeuropsychological test performanceBrain volumeSmaller total brain volumeVolumes of caudateTotal brain volumeBasal ganglia abnormalitiesOverall brain volumeLarger putamen volumesTotal brainGlobus pallidusPutamen volumeNormal individualsGangliaTest performanceNeuropsychological testsSignificant correlationSyndromeAge
1994
Depression Induced Cognitive Impairment
Rabins P, Pearlson G. Depression Induced Cognitive Impairment. 1994, 667-679. DOI: 10.1007/978-1-4615-6805-6_41.Peer-Reviewed Original ResearchAffective disordersCognitive impairmentAffective syndromeOrganic affective syndromeInduced Cognitive ImpairmentCognitive-affective disordersPoor cognitive performanceTerm pseudodementiaDementia syndromesClinical stateDelirious maniaSet of symptomsCognitive symptomsCognitive disordersAffective symptomsType 2Type 1SyndromeSymptomsDisordersCognitive performanceDepressionPseudodementiaImpairmentPrimary condition
1988
Manic Syndrome Associated With Zidovudine
Schaerf F, Miller R, Pearlson G, Kaminsky M, Weaver D. Manic Syndrome Associated With Zidovudine. JAMA 1988, 260: 3587-3588. DOI: 10.1001/jama.1988.03410240045016.Peer-Reviewed Original ResearchCases of maniaZidovudine therapySyndrome AssociatedHuman immunodeficiency virus-seropositive individualsAffective disordersImmunodeficiency syndrome dementia complexZidovudine dosageZidovudine treatmentSuch patientsDementia complexManic episodesMajor depressionFamily historyDepressive symptomsCognitive declinePsychiatric syndromesPatientsPersonal historyZidovudineTherapyEt al1ManiaDisordersAssociatedSyndromeD2 DOPAMINE RECEPTORS IN TOURETTE'S SYNDROME AND MANIC DEPRESSIVE ILLNESS
Wong D, Singer H, Pearlson G, Tune L, Ross C, Villemagne V, Dannals R, Links J, Wilson A, Ravert H, Wagner H, Gjedde A. D2 DOPAMINE RECEPTORS IN TOURETTE'S SYNDROME AND MANIC DEPRESSIVE ILLNESS. Clinical Nuclear Medicine 1988, 13: 392. DOI: 10.1097/00003072-198805000-00040.Peer-Reviewed Original ResearchManic-depressive illnessTourette syndromeDepressive illnessPsychotic symptomsD2 dopamine receptor densityDrug-free patientsDopamine receptor densityGreater clinical severityD2 dopamine receptorsOral haloperidolFree patientsMotor abnormalitiesAntagonist haloperidolClinical severityTourette patientsDopamine receptorsReceptor densityParkinson's diseaseCommon treatmentPsychiatric disordersActive psychosisSyndromePatientsAdult subjectsBmax values