2024
Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Meyhoefer I, Sprenger A, Derad D, Grotegerd D, Leenings R, Leehr E, Breuer F, Surmann M, Rolfes K, Arolt V, Romer G, Lappe M, Rehder J, Koutsouleris N, Borgwardt S, Schultze-Lutter F, Meisenzahl E, Kircher T, Keedy S, Bishop J, Ivleva E, McDowell J, Reilly J, Hill S, Pearlson G, Tamminga C, Keshavan M, Gershon E, Clementz B, Sweeney J, Hahn T, Dannlowski U, Lencer R. Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis. Scientific Reports 2024, 14: 13859. PMID: 38879556, PMCID: PMC11180169, DOI: 10.1038/s41598-024-64487-6.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsPsychosis syndromePursuit eye movementsNon-psychotic bipolar disorderNon-psychotic affective disorderEye movementsSmooth pursuit dysfunctionMultivariate pattern analysisHealthy controlsPsychiatric sampleNeurobiological markersPsychosis probandsPsychotic syndromesAffective disordersPsychosis researchBipolar disorderPsychosis statusPsychosisSensorimotor functionSensorimotor measuresIndividual levelSensorimotor dysfunctionSensorimotorDisordersPattern analysis
2017
5.3 Endophenotypes Guide Psychosis Neurobiology Formulations
Tamminga C, Clementz B, Keshavan M, Gershon E, Pearlson G, Ivleva E. 5.3 Endophenotypes Guide Psychosis Neurobiology Formulations. Schizophrenia Bulletin 2017, 43: s7-s7. DOI: 10.1093/schbul/sbx021.019.Peer-Reviewed Original ResearchConventional diagnosisFunctional brain biomarkersBiomarker compositesGray matter changesPsychosis researchHealthy controlsAdditional biomarkersClear pathophysiologyBrain biomarkersMatter changesAxis IProband groupsBiotype 1Higher negative symptomsLifetime ratesPsychiatric conditionsNegative symptomsPsychosis groupPsychotic conditionsSchizophrenia NetworkDistinct molecular markersDiagnosisAdolescent cannabisBiomarkersEEG characteristics