1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1988
BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD)
LaFrance N, Pearlson G, Folstein S, Cole P, Turek J, Kumar A, Bascom M, McDonald A, Folstein M, Wagner H. BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD). Clinical Nuclear Medicine 1988, 13: 392. DOI: 10.1097/00003072-198805000-00039.Peer-Reviewed Original ResearchEarly HD patientsMini-Mental StateHD patientsHuntington's diseaseNeurological examinationMini-Mental State scoresDuration of diseaseGenotype-positive individualsEarly Huntington's diseaseMental state scoresForamen of MonroPotential therapeutic interventionsNormal CTFirst manifestationPositive individualsMRI studiesPatientsPreclinical measuresTherapeutic interventionsIodoamphetamineIMP accumulationDiseaseBrain imagingState scoresSignificant decrement