2023
A data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Da Silva M, Melendez‐Torres G, Ismail Z, Testad I, Ballard C, Creese B, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Van der Swag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledoMorrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D'Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. A data‐driven examination of apathy and depressive symptoms in dementia with independent replication. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12398. PMID: 36777092, PMCID: PMC9899765, DOI: 10.1002/dad2.12398.Peer-Reviewed Original ResearchNeuropsychiatric symptomsDepressive symptomsLatent class analysisDifferent clinical associationsPoor clinical outcomeCommon neuropsychiatric symptomsApathy/depressionClinical outcomesClinical associationsIndependent cohortDepression syndromeDiagnostic criteriaClinical practiceApathy syndromeDepression symptomsSymptomsDiagnostic categoriesBiomarker studiesDepressionSyndromeLatent class membershipCohortFour-class solutionApathyData-driven examination
1996
A Quantitative MRI Study of the Basal Ganglia in Depression in HIV Seropositive Men
Davison S, Aylward E, McArthur J, Selnes O, Lyketsos C, Barta P, Pearlson G. A Quantitative MRI Study of the Basal Ganglia in Depression in HIV Seropositive Men. Journal Of LGBT Health Research 1996, 1: 29-41. PMID: 16873169, DOI: 10.1300/j128v01n03_02.Peer-Reviewed Original ResearchConceptsHIV-seropositive menBasal ganglia volumesBasal ganglia atrophyBasal gangliaMagnetic resonance imagingSeropositive menGanglia volumesHIV infectionHIV-seropositive homosexual menSeropositive homosexual menHIV-seropositive patientsQuantitative MRI studyQuantitative magnetic resonance imagingSeropositive patientsSuch infectionsComparison subjectsMRI studiesHomosexual menAffective disordersDepressive symptomatologyGangliaResonance imagingInfectionSignificant differencesDepressionMajor Depression in Alzheimer's Disease An Interaction Between Gender and Family History
Lyketsos C, Tune L, Pearlson G, Steele C. Major Depression in Alzheimer's Disease An Interaction Between Gender and Family History. Journal Of The Academy Of Consultation-Liaison Psychiatry 1996, 37: 380-384. PMID: 8701017, DOI: 10.1016/s0033-3182(96)71552-9.Peer-Reviewed Original Research
1994
Depression Induced Cognitive Impairment
Rabins P, Pearlson G. Depression Induced Cognitive Impairment. 1994, 667-679. DOI: 10.1007/978-1-4615-6805-6_41.Peer-Reviewed Original ResearchAffective disordersCognitive impairmentAffective syndromeOrganic affective syndromeInduced Cognitive ImpairmentCognitive-affective disordersPoor cognitive performanceTerm pseudodementiaDementia syndromesClinical stateDelirious maniaSet of symptomsCognitive symptomsCognitive disordersAffective symptomsType 2Type 1SyndromeSymptomsDisordersCognitive performanceDepressionPseudodementiaImpairmentPrimary condition
1991
Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
Pearlson G, Rabins P, Burns A. Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia. Psychological Medicine 1991, 21: 321-328. PMID: 1876637, DOI: 10.1017/s0033291700020420.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCT attenuation numbersGray matterAttenuation numberCranial CT scanLate-life depressionElderly patientsReversible dementiaPatient groupCT changesLife depressionMajor depressionCentrum semiovaleAttenuation valuesCT scanNormal controlsElderly controlsNeuropsychological evaluationNormal agingDiseasePatientsDepressionCognitive tasksDementiaReliable means
1990
Language performance deficits in elderly depressed patients
Speedie L, O'donnell W, Rabins P, Pearlson G, Poggi M, Rothi L. Language performance deficits in elderly depressed patients. Aphasiology 1990, 4: 197-205. DOI: 10.1080/02687039008249070.Peer-Reviewed Original ResearchLanguage performancePerformance deficitsElderly depressed patientsDepressed patientsLanguage functionJudgment difficultyNormal elderly subjectsCognitive impairmentAffective disordersDeficitsEducational levelMajor affective disordersElderly subjectsMemoryDifficultiesFurther explorationImpairmentDepressionLanguageDisordersPerformanceConfrontationNormal groupConfrontation naming deficit in dementia of depression
Speedie L, Rabins P, Pearlson G, Moberg P. Confrontation naming deficit in dementia of depression. Journal Of Neuropsychiatry 1990, 2: 59-63. PMID: 2136062, DOI: 10.1176/jnp.2.1.59.Peer-Reviewed Original ResearchConceptsDementia of depressionDelayed visual memoryIrreversible dementiaMemory taskVisual memoryFree recallLanguage abilityNondepressed control subjectsDepressed patientsMemoryCognitive impairmentNormal cognitionElderly depressed patientsRecallDepressionTaskDementiaMajor depressionReversible dementiaPatient groupControl subjectsCognitionPatientsDeficitsConfrontation
1984
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey J, Pearlson G, Robinson R, Rao K, Price T. NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY. The Lancet 1984, 323: 297-300. PMID: 6141377, DOI: 10.1016/s0140-6736(84)90356-8.Peer-Reviewed Original ResearchConceptsPost-stroke depressionDouble-blind studyDepression ScaleEfficacy of nortriptylinePlacebo-treated patientsSerum nortriptyline levelsHamilton Depression ScalePresent State ExaminationZung Depression ScaleStroke patientsTherapeutic rangeMajor depressionNortriptyline levelsDemonstrated efficacyState ExaminationPatientsNortriptylineDepressionGreater improvementTreatmentSimilar groupsEfficacyImportant addition
1983
Mood Change following Bilateral Hemisphere Brain Injury
Lipsey J, Robinson R, Pearlson G, Rao K, Price T. Mood Change following Bilateral Hemisphere Brain Injury. The British Journal Of Psychiatry 1983, 143: 266-273. PMID: 6626839, DOI: 10.1192/bjp.143.3.266.Peer-Reviewed Original ResearchConceptsHemisphere brain injuryFunctional physical impairmentBrain injuryCognitive impairmentPhysical impairmentLeft frontal lobe lesionFrontal lobe lesionsThromboembolic strokeBrain lesionsSuch injuriesCT scanLesion locationDepression severityLobe lesionsLesion proximityDepressive symptomatologyLesion ageFrontal poleInjuryMood changesPatientsImpairmentMood ScaleLesionsDepression