2025
Recent Survival Gains in Stage IV Non-Small Cell Lung Cancer by Sociodemographic Strata
Ayoade O, Canavan M, Zolfaghari E, Caturegli G, Kim S, Boffa D. Recent Survival Gains in Stage IV Non-Small Cell Lung Cancer by Sociodemographic Strata. JTO Clinical And Research Reports 2025, 100798. DOI: 10.1016/j.jtocrr.2025.100798.Peer-Reviewed Original ResearchNon-small cell lung cancerStage IV non-small cell lung cancerIV non-small cell lung cancerStage IV NSCLC patientsIV NSCLC patientsCell lung cancerMedian survivalNSCLC patientsLung cancerNon-small cell lung cancer patientsNational Cancer DatabaseKaplan Meier methodTwo-year survivalStratified Cox analysisAdjusted mortality riskMeier methodCancer DatabaseCox analysisEra 1NSCLC treatmentSurvival gainChemotherapy administrationNon-Hispanic blacksPatientsHispanic patients
2024
Brief Report: Should a prior cancer history be reevaluated as an exclusion for clinical trial participation?
Ayoade O, Canavan M, Caturegli G, Boffa D. Brief Report: Should a prior cancer history be reevaluated as an exclusion for clinical trial participation? Lung Cancer 2024, 198: 108032. PMID: 39561624, DOI: 10.1016/j.lungcan.2024.108032.Peer-Reviewed Original ResearchNon-small cell lung cancerAssociated with superior survivalSuperior survivalStage III NSCLC patientsCancer historyIII NSCLC patientsReceipt of immunotherapyNational Cancer DatabaseRegimens of chemotherapyStage IV patientsAnalyze overall survivalCell lung cancerKaplan Meier analysisStage III andCox proportional hazards modelsProportional hazards modelInnovative treatment approachesInfluence patient outcomesNSCLC patientsIV patientsOverall survivalImmunotherapy trialsCancer DatabaseMeier analysisNon-smallLung Cancer Screening at US Hospitals for People Lacking Primary Care
DeSantis W, Ayoade O, Caturegli G, Boffa D. Lung Cancer Screening at US Hospitals for People Lacking Primary Care. JAMA Network Open 2024, 7: e2442373. PMID: 39480427, PMCID: PMC11528307, DOI: 10.1001/jamanetworkopen.2024.42373.Peer-Reviewed Original ResearchNational trends and outcomes of total proctocolectomy and completion proctectomy ileal pouch−anal anastomosis procedures for ulcerative colitis
Chen S, Radomski S, Stem M, Done J, Caturegli G, Atallah C, Efron J, Safar B. National trends and outcomes of total proctocolectomy and completion proctectomy ileal pouch−anal anastomosis procedures for ulcerative colitis. Colorectal Disease 2024, 26: 497-507. PMID: 38302723, DOI: 10.1111/codi.16891.Peer-Reviewed Original ResearchConceptsAssociated with increased oddsTPC-IPAASteroid/immunosuppressive therapyUlcerative colitisTotal proctocolectomySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseFactors associated with 30-dayIleal pouch-anal anastomosis procedureOutcomes of ulcerative colitisQuality Improvement Program databaseIleal pouch-anal anastomosisAdult UC patientsAnastomotic leak ratePouch-anal anastomosisLonger hospital lengthMultivariate logistic regressionIncreased morbidity riskDelayed surgeryObese patientsCompletion proctectomyUC patientsProgram databaseHospital lengthUnadjusted analysis
2023
Brief Report: Changing Characteristics Among In-Hospital HIV Deaths: An 11-Year Retrospective Review of a Regional Hospital in South Africa
Lombardo A, Materi J, Caturegli G, Milovanovic M, Martinson N, Calver A, Nonyane B, Golub J, Hoffmann C, Variava E. Brief Report: Changing Characteristics Among In-Hospital HIV Deaths: An 11-Year Retrospective Review of a Regional Hospital in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 185-189. PMID: 37757855, DOI: 10.1097/qai.0000000000003249.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyExpansion of antiretroviral therapyHIV-positiveProportion of decedentsBurden of HIVAge groupsProportion of HIV patientsAge of decedentsHIV-associated mortalityProportion of HIV-positiveYounger age groupsOlder age groupsHealth facilitiesDecedent characteristicsLog-binomialAIDS-defining illnessRegional hospitalHIV deathsHIV statusAdvanced HIV diseaseRecord dataMultinomial regressionOlder individualsOpportunistic illnessesProportion of patientsTrends on Near-Infrared Spectroscopy Associated With Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation
Zhao D, Shou B, Caturegli G, Whitman G, Kim B, Cho S, Investigators O. Trends on Near-Infrared Spectroscopy Associated With Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2023, 69: 1083-1089. PMID: 37556554, PMCID: PMC10843160, DOI: 10.1097/mat.0000000000002032.Peer-Reviewed Original ResearchConceptsCerebral near-infrared spectroscopyArea under the curveVenoarterial extracorporeal membrane oxygenationAcute brain injuryVA-ECMO patientsExtracorporeal membrane oxygenationVA-ECMOMembrane oxygenationCerebral regional oxygen saturationHypoxic ischemic brain injuryAssociated with acute brain injuryRegional oxygen saturationBrain injuryIschemic brain injuryECMO cannulationCerebral desaturationIntracranial hemorrhageConsecutive hoursNIRS monitoringOxygen saturationECMOIncreased oddsIschemic strokePatientsRSO 2Challenges in determining death by neurologic criteria in extracorporeal membrane oxygenation – A single center experience
Zhao D, Caturegli G, Wilcox C, Stephens R, Kim B, Keller S, Geocadin R, Suarez J, Whitman G, Cho S. Challenges in determining death by neurologic criteria in extracorporeal membrane oxygenation – A single center experience. Perfusion 2023, 39: 1238-1246. PMID: 37387124, PMCID: PMC10756925, DOI: 10.1177/02676591231187548.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenation patientsExtracorporeal membrane oxygenationApnea testingWithdrawal of life-sustaining treatmentAncillary testsMembrane oxygenationSingle center experienceVV ECMO patientsTertiary care centerAbsent brainstem reflexesNeurological exam findingsLife-sustaining treatmentVV-ECMORetrospective reviewTertiary centerImaging findingsExam findingsBrainstem reflexesCenter's experienceNeurological examPatientsDiagnostic criteriaCare centerDetermination of DNCNeurologic criteriaCharacteristics of delirium and its association with sedation and in-hospital mortality in patients with COVID-19 on veno-venous extracorporeal membrane oxygenation
Sun P, Fanning J, Peeler A, Shou B, Lindsley J, Caturegli G, Whitman G, Cha S, Kim B, Cho S, investigators H. Characteristics of delirium and its association with sedation and in-hospital mortality in patients with COVID-19 on veno-venous extracorporeal membrane oxygenation. Frontiers In Medicine 2023, 10: 1172063. PMID: 37305142, PMCID: PMC10248255, DOI: 10.3389/fmed.2023.1172063.Peer-Reviewed Original ResearchAcute respiratory distress syndromeVeno-venous extracorporeal membrane oxygenationCOVID-19 acute respiratory distress syndromeIn-hospital mortalityVV-ECMOExtracorporeal membrane oxygenationRichmond Agitation-Sedation ScaleProportion of daysMembrane oxygenationLonger duration of deliriumNon-survivorsSevere COVID-19 acute respiratory distress syndromeCharacteristics of deliriumRespiratory distress syndromeDelirium daysAssociated with sedationAverage daily dosageMultivariate logistic regressionAssociated with mortalityDuration of deliriumConfusion Assessment MethodECMO durationECMO daysDistress syndromeAdult patientsManagement of Anticoagulation Therapy in ECMO-Associated Ischemic Stroke and Intracranial Hemorrhage
Prokupets R, Kannapadi N, Chang H, Caturegli G, Bush E, Kim B, Keller S, Geocadin R, Whitman G, Cho S, Acton M, Rando H, Alejo D, Calligy K, Anderson S, Shou B, Sussman M, Wilcox C, Zhang L, Brown P, Peeler A. Management of Anticoagulation Therapy in ECMO-Associated Ischemic Stroke and Intracranial Hemorrhage. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2023, 18: 49-57. PMID: 36628944, PMCID: PMC10236353, DOI: 10.1177/15569845221141702.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIntracranial hemorrhageVA-ECMOVV-ECMOAnticoagulation managementManagement of anticoagulant therapyAntithrombotic therapy managementICH expansionVA-ECMO patientsVenovenous (VVIschemic strokeResumption of anticoagulationExtracorporeal membrane oxygenationCohort of patientsTertiary care centerOptimal anticoagulation managementDiagnosis of acute ischemic strokeIn-hospital mortalityIntracranial hemorrhage survivorsAcute ischemic stroke survivorsAnticoagulation reversalECMO patientsAnticoagulant therapyThromboembolic eventsMembrane oxygenation
2022
Characterization of Cerebral Hemodynamics with TCD in Patients Undergoing VA-ECMO and VV-ECMO: a Prospective Observational Study
Caturegli G, Zhang L, Mayasi Y, Gusdon A, Ergin B, Ponomarev V, Kim B, Keller S, Geocadin R, Whitman G, Cho S, Ziai W. Characterization of Cerebral Hemodynamics with TCD in Patients Undergoing VA-ECMO and VV-ECMO: a Prospective Observational Study. Neurocritical Care 2022, 38: 407-413. PMID: 36510107, PMCID: PMC9744662, DOI: 10.1007/s12028-022-01653-6.Peer-Reviewed Original ResearchConceptsVA-ECMOVV-ECMOIntraparenchymal hemorrhageTCD studiesAssociated with intraparenchymal hemorrhageComposite bleeding eventsCerebral hemodynamicsVA-ECMO patientsSingle-center cohortTCD-mean flow velocityBackgroundExtracorporeal membrane oxygenationVV ECMO patientsTertiary care centerProspective observational studyProspective cohort studyInternal carotid arteryAcute brain injuryVenovenous ECMOECMO populationBleeding eventsECMO modeMembrane oxygenationMulticenter studyVenoarterial ECMOPulsatility indexEarly Low Pulse Pressure in VA-ECMO Is Associated with Acute Brain Injury
Shou B, Wilcox C, Florissi I, Kalra A, Caturegli G, Zhang L, Bush E, Kim B, Keller S, Whitman G, Cho S. Early Low Pulse Pressure in VA-ECMO Is Associated with Acute Brain Injury. Neurocritical Care 2022, 38: 612-621. PMID: 36167950, PMCID: PMC10040467, DOI: 10.1007/s12028-022-01607-y.Peer-Reviewed Original ResearchConceptsAssociated with acute brain injuryAcute brain injuryLower pulse pressureHypoxic ischemic brain injuryVA-ECMOIschemic brain injuryPulse pressureIntracranial hemorrhageCerebral edemaVenoarterial extracorporeal membrane oxygenationECMO day 1VA-ECMO patientsIschemic strokeExtracorporeal membrane oxygenationRetrospective analysis of adultsBrain injuryMarkers of cardiovascular functionTertiary care centerPulse pressure <Multivariate logistic regressionBrain deathContinuous-flow mechanical circulatory supportMechanical circulatory supportAnalysis of adultsECMO supportTranscranial Doppler microemboli and acute brain injury in extracorporeal membrane oxygenation: A prospective observational study
Caturegli G, Kapoor S, Ponomarev V, Kim B, Whitman G, Ziai W, Cho S, Investigators H, Zhang L, Mayasi Y, Gusdon A, Ergin B, Keller S, Acton M, Rando H, Alejo D, Calligy K, Anderson S, Shou B, Mendez-Tellez P, Chang H, Sussman M, Wilcox C, Brown P, Peeler A. Transcranial Doppler microemboli and acute brain injury in extracorporeal membrane oxygenation: A prospective observational study. JTCVS Techniques 2022, 15: 111-122. PMID: 36276670, PMCID: PMC9579875, DOI: 10.1016/j.xjtc.2022.07.026.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationAcute brain injuryIntra-aortic balloon pumpTranscranial Doppler examinationVA-ECMOVV-ECMOMicroembolic signalsAssociated with presenceTranscranial DopplerMembrane oxygenationBalloon pumpLong-term neurologic follow-upVentricular assist deviceVA extracorporeal membrane oxygenationECMO parametersExtracorporeal membrane oxygenation circuitMultivariate logistic regression analysisVenovenous (VVArterial thromboembolic eventsCohort of patientsTertiary care centerNeurological follow-upMicroembolic signal monitoringProspective observational studyProspective cohort studyCARC13: Early Low Pulsatility in VA-ECMO is Associated with Acute Brain Injury
Shou B, Kalra A, Wilcox C, Caturegli G, Al-Kawaz M, Bush E, Kim B, Keller S, Whitman G, Cho S. CARC13: Early Low Pulsatility in VA-ECMO is Associated with Acute Brain Injury. ASAIO Journal 2022, 68: 37-37. DOI: 10.1097/01.mat.0000840916.15737.fa.Peer-Reviewed Original ResearchL-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2021
748: CEREBRAL HEMODYNAMICS WITH TCD IN ECMO
Caturegli G, Choi C, Geocadin R, Whitman G, Cho S, Ziai W. 748: CEREBRAL HEMODYNAMICS WITH TCD IN ECMO. Critical Care Medicine 2021, 50: 368-368. DOI: 10.1097/01.ccm.0000809316.17322.1a.Peer-Reviewed Original ResearchThe Impact of Surgical Delays on Short- and Long-Term Survival Among Colon Cancer Patients
Lo B, Caturegli G, Stem M, Biju K, Safar B, Efron J, Rajput A, Atallah C. The Impact of Surgical Delays on Short- and Long-Term Survival Among Colon Cancer Patients. The American Surgeon 2021, 87: 1783-1792. PMID: 34666557, DOI: 10.1177/00031348211047511.Peer-Reviewed Original ResearchConceptsColon cancer patientsImpact of surgical delayOverall survivalIII colon cancerLong-term survivalSurgical delayCancer patientsSurgery 3Associated with worse 5-year overall survivalColon cancerDisease stageStage IStage III colon cancerNational Cancer DatabaseDiagnosis to surgeryPathological disease stageII diseaseCancer DatabaseGt;12 weeksAdult patientsSubgroup analysisColon cancer diagnosisSurgeryPatientsWaiting timeStress-Induced (Takotsubo) Cardiomyopathy After Liver Transplant Rescued with Venoarterial Extracorporeal Membrane Oxygenation
Caturegli G, Crane M, Etchill E, Giuliano K, Nguyen M, Philosophe B, Cho S, Wittstein I, Whitman G. Stress-Induced (Takotsubo) Cardiomyopathy After Liver Transplant Rescued with Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2021, 68: e66-e68. PMID: 35349528, DOI: 10.1097/mat.0000000000001453.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationLiver transplantationVA-ECMOTakotsubo syndromeMembrane oxygenationRefractory to high-doseYear old male patientRecovery of cardiac functionDeceased donor liver transplantationStress-induced cardiomyopathyOld male patientDonor liver transplantationHigh-doseMale patientsMedical therapyCardiac functionHepatic graftMyocardial recoveryPatientsCardiovascular diseaseTransplantationCardiomyopathyLiverTakotsuboDuration of Hyperoxia and Neurologic Outcomes in Patients Undergoing Extracorporeal Membrane Oxygenation
Al-Kawaz M, Canner J, Caturegli G, Kannapadi N, Balucani C, Shelley L, Kim B, Choi C, Geocadin R, Whitman G, Cho S. Duration of Hyperoxia and Neurologic Outcomes in Patients Undergoing Extracorporeal Membrane Oxygenation. Critical Care Medicine 2021, 49: e968-e977. PMID: 33935164, DOI: 10.1097/ccm.0000000000005069.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationPoor neurological outcomeNeurological outcomeMembrane oxygenationDuration of hyperoxiaSevere hyperoxiaExtracorporeal membrane oxygenation patientsAssociated with poor neurological outcomeVenoarterial extracorporeal membrane oxygenation patientsMultivariate logistic regression analysisArea under the curveModified Rankin ScaleAssociated with inhospital mortalityLogistic regression analysisJohns Hopkins HospitalOxygenation patientsRetrospective analysisInhospital mortalityMultivariate analysisPrimary outcomeRankin ScaleNeurological functionPatientsPaO2 valuesManagement of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature
Kannapadi N, Alomari S, Caturegli G, Bydon A, Cho S. Management of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature. Journal Of Clinical Neuroscience 2021, 87: 20-25. PMID: 33863527, DOI: 10.1016/j.jocn.2021.01.052.Peer-Reviewed Original ResearchConceptsSurgical interventionDeterminants of tuberculosisSurgically managed patientsCase-control studyTB meningitisMedian ageTB presentationMedian timeClinical characteristicsCase reportSyringomyelia casesTB onsetPost-treatment outcomesSystematic reviewTB infectionInclusion criteriaManaging patientsSyringomyeliaNo treatmentPatientsPrior symptomsInterventionOutcomesSample sizeTuberculosisCerebral Microbleeds and Intracranial Hemorrhages in Adult Patients on Extracorporeal Membrane Oxygenation—Autopsy Study
Hwang J, Caturegli G, White B, Chen L, Cho S. Cerebral Microbleeds and Intracranial Hemorrhages in Adult Patients on Extracorporeal Membrane Oxygenation—Autopsy Study. Critical Care Explorations 2021, 3: e0358. PMID: 33681814, PMCID: PMC7929626, DOI: 10.1097/cce.0000000000000358.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenation supportMembrane oxygenation supportOxygen supportCerebral microbleedsExtracorporeal membrane oxygenation nonsurvivorsExtracorporeal membrane oxygenation durationExtracorporeal membrane oxygenation patientsExtracorporeal membrane oxygenation typeExtracorporeal membrane oxygenation survivorsFactors of cerebral microbleedsPresence of cerebral microbleedsExtracorporeal membrane oxygenationAssociated with cerebral microbleedsLong-term sequelaeOxygenation durationBloodstream infectionsIntracranial hemorrhageIntraparenchymal hemorrhageMembrane oxygenationReviewed patientsAdult patientsOxygenation patientsSubarachnoid hemorrhageUnivariate analysisBlood products