Gabriela Pizzurro
Associate Research ScientistCards
About
Research
Publications
2021
3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting Phenotype
Pizzurro GA, Liu C, Bridges K, Alexander AF, Huang A, Baskaran JP, Ramseier J, Bosenberg MW, Mak M, Miller-Jensen K. 3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting Phenotype. Cancers 2021, 13: 4579. PMID: 34572807, PMCID: PMC8471848, DOI: 10.3390/cancers13184579.Peer-Reviewed Original ResearchTumor-associated macrophagesMelanoma tumor microenvironmentTumor microenvironmentTumor-promoting phenotypeAnti-tumor activityImmunosuppressive stateDisease progressionCo-culture systemImmune responseImmune activitySecretion profileDirect cell-cell interactionsMelanoma tumorsStromal componentsMacrophage transitionStromal cellsTumor cellsMelanoma cellsTopical arginase inhibition decreases growth of cutaneous squamous cell carcinoma
Mittal A, Wang M, Vidyarthi A, Yanez D, Pizzurro G, Thakral D, Tracy E, Colegio OR. Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. Scientific Reports 2021, 11: 10731. PMID: 34031449, PMCID: PMC8144401, DOI: 10.1038/s41598-021-90200-y.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaArginase inhibitionB6 miceCell carcinomaAnti-PD-1 therapeutic efficacyTumor growthArginase inhibitorAnti-PD-1 therapyPD-1 expressionAppropriate tumor modelsCSCC cell linesPre-clinical modelsTumor growth inhibitionNOHA administrationSignificant morbidityC57BL/6 miceImmune microenvironmentImmunocompetent miceCSCC tumorsDeficient miceT cellsMacrophage expressionTherapeutic modalitiesTherapeutic efficacy
2015
Cytokine-enhanced maturation and migration to the lymph nodes of a human dying melanoma cell-loaded dendritic cell vaccine.
Pizzurro GA, Tapia IJ, Sganga L, Podhajcer OL, Mordoh J, Barrio MM. Cytokine-enhanced maturation and migration to the lymph nodes of a human dying melanoma cell-loaded dendritic cell vaccine. Cancer Immunol Immunother 2015, 64: 1393-406. PMID: 26197849, DOI: 10.1007/s00262-015-1743-z.Peer-Reviewed Original ResearchDendritic cell-based vaccine efficacy: aiming for hot spots.
Pizzurro GA, Barrio MM. Dendritic cell-based vaccine efficacy: aiming for hot spots. Front Immunol 2015, 6: 91. PMID: 25784913, DOI: 10.3389/fimmu.2015.00091.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2013
High lipid content of irradiated human melanoma cells does not affect cytokine-matured dendritic cell function.
Pizzurro GA, Madorsky Rowdo FP, Pujol-Lereis LM, Quesada-Allué LA, Copati AM, Roberti MP, Teillaud JL, Levy EM, Barrio MM, Mordoh J. High lipid content of irradiated human melanoma cells does not affect cytokine-matured dendritic cell function. Cancer Immunol Immunother 2013, 62: 3-15. PMID: 22722447, DOI: 10.1007/s00262-012-1295-4.Peer-Reviewed Original Research
2012
Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells.
Barrio MM, Abes R, Colombo M, Pizzurro G, Boix C, Roberti MP, Gélizé E, Rodriguez-Zubieta M, Mordoh J, Teillaud JL. Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells. PLoS One 2012, 7: e40311. PMID: 22768350, DOI: 10.1371/journal.pone.0040311.Peer-Reviewed Original Research