1995
Clinical investigative perspective
Wackers F. Clinical investigative perspective. Journal Of Nuclear Cardiology 1995, 2: 75-77. PMID: 9420766, DOI: 10.1016/s1071-3581(05)80012-1.Peer-Reviewed Original ResearchConceptsClinical useExciting new agentPhase III studyNew imaging agentWidespread clinical useIII studyNew agentsClinical protocolsClinical investigatorsNew radiopharmaceuticalsExperienced investigatorsImaging agentCliniciansAcademic investigatorsInvestigatorsFinal approvalExciting new discoveriesScientific evaluationRadiopharmaceutical researchAgentsImaging methodology
1993
Factors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial
Wackers F, Bodenheimer M, Fleiss J, Brown M, Investigators T. Factors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial. Journal Of The American College Of Cardiology 1993, 21: 1064-1074. PMID: 8459059, DOI: 10.1016/0735-1097(93)90226-q.Peer-Reviewed Original ResearchConceptsClinical centersThallium-201 imagesCore laboratoryClinical investigatorsSilent myocardial ischemiaPlanar thallium-201 imagesThallium-201 imagingLack of standardizationCircumferential profile analysisPlanar thallium-201 imagingReproducibility of interpretationMulticenter trialMulticenter studyMyocardial ischemiaMyocardial perfusion imagesSuboptimal reproducibilityInterobserver agreementKappa statisticsPerfusion imagesPoor interlaboratory agreementComputer quantificationObjective criteriaInterlaboratory agreementPoor agreementEffects of standardization