2014
Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells
Kim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee F. Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. Journal Of Orthopaedic Research® 2014, 32: 848-854. PMID: 24536031, DOI: 10.1002/jor.22598.Peer-Reviewed Original ResearchConceptsPERK1/2 inhibitionHuman osteosarcoma cellsBim expressionSubset of patientsOsteosarcoma cellsConventional cytotoxic agentsConventional cytotoxic treatmentAnti-cancer effectsInhibition of pERK1/2Pro-apoptotic mechanismsMultifocal osteosarcomaMultimodality chemotherapyCytotoxic treatmentUpregulation of BimOsteosarcoma treatmentOsteosarcoma cell deathCytotoxic agentsExpression of BimPotential mediatorsTreatment of PD98059UpregulationTreatmentPD98059 treatmentInhibitionCell death
2011
Targeting Inflammatory Kinase as an Adjuvant Treatment for Osteosarcomas
Noh K, Kim KO, Patel NR, Staples JR, Minematsu H, Nair K, Lee FY. Targeting Inflammatory Kinase as an Adjuvant Treatment for Osteosarcomas. Journal Of Bone And Joint Surgery 2011, 93: 723-732. PMID: 21508279, PMCID: PMC6882535, DOI: 10.2106/jbjs.j.00302.Peer-Reviewed Original ResearchConceptsOsteosarcoma-bearing miceDoxorubicin treatmentVehicle-treated control miceVehicle-treated miceSubset of patientsConventional cytotoxic chemotherapyCell deathOsteosarcoma cellsAnti-cancer effectsAnti-apoptotic protein expressionSignal-regulated kinase 1/2Bcl-2-mediated resistanceInflammatory kinasesAdjuvant treatmentCytotoxic chemotherapyUntreated miceControl miceTreatment outcomesTherapeutic effectERK pathway inhibitorAnti-apoptotic proteinsNude miceAnimal morbidityAggressive osteosarcomaOsteosarcoma cell death
2004
Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP).
Delloye C, Suratwala SJ, Cornu O, Lee FY. Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP). Acta Orthopaedica Belgica 2004, 70: 591-7. PMID: 15669462.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Morphogenetic ProteinsBone NeoplasmsBone TransplantationFemaleFollow-Up StudiesFractures, UnunitedHumansMaleMiddle AgedOsteosarcomaRadiographyRetrospective StudiesRisk AssessmentSampling StudiesSarcoma, EwingSensitivity and SpecificityTransplantation, HomologousTreatment OutcomeConceptsAllograft-host junctionAllograft nonunionRecombinant human bone morphogenetic proteinAllograft fractureIntercalary allograftsFracture nonunionHuman bone morphogenetic proteinAdditional radiation therapyMalignant bone tumorsRhBMP-7Allograft bone transplantationBone morphogenetic proteinAdjuvant chemotherapySterile drainageRadiological evidenceCorticocancellous allograftFemoral allograftsTibial nonunionWide resectionOsteoarticular allograftsTumor recurrenceMain complicationsNonunion siteBone tumorsRadiation therapy