2019
Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures.
Henderson SE, Yu K, Alder KD, Ibe IK, Lee FY, Lindskog DM. Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures. Instructional Course Lectures 2019, 68: 607-612. PMID: 32032089.Peer-Reviewed Original ResearchConceptsPathologic fractureSkeletal metastasesTibial reconstructionCommon reconstructive optionsRisk of complicationsSoft tissue involvementHistory of radiationImproved patient outcomesSubsequent revision proceduresLarge skeletal defectsGoal of reconstructionSystemic therapyGoal of managementPatient outcomesSurgical reconstructionReconstructive optionsRevision proceduresEndoprosthesis implantationIntramedullary nailImplant failureLarge bone defectsMetastasisBone defectsSkeletal defectsFractures
2012
Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells
Lee HG, Hsu A, Goto H, Nizami S, Lee JH, Cadet ER, Tang P, Shaji R, Chandhanayinyong C, Kweon SH, Oh DS, Tawfeek H, Lee FY. Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells. American Journal Of Physiology - Cell Physiology 2012, 304: c431-c439. PMID: 23255578, PMCID: PMC3602649, DOI: 10.1152/ajpcell.00202.2012.Peer-Reviewed Original ResearchConceptsBone-implant junctionEffect of particlesAbsence of TiWear particlesShear stressMechanical loadingTitanium particlesMetal implantsMechanical perturbationsMechanical strainFluid pressureParticlesBone tissueOsseous integrationTiOsteoprogenitor cellsImplant failureLoadingGene expressionCombined effectMechanical stimuliInterface