The involvement of the cerebellar vermis across the psychotic-affective spectrum in enriched samples of recent-onset schizophrenia, bipolar disorder, and major depressive disorder
Xiao Y, Kandala S, Huang J, Liu J, McGonigle T, Barch D, Tang Y, Fan G, Wang F, Womer F. The involvement of the cerebellar vermis across the psychotic-affective spectrum in enriched samples of recent-onset schizophrenia, bipolar disorder, and major depressive disorder. Journal Of Psychiatric Research 2024, 181: 14-22. PMID: 39577028, DOI: 10.1016/j.jpsychires.2024.11.023.Peer-Reviewed Original ResearchBipolar disorderFunctional connectivityVermis volumeDepressive disorderCognitive measuresSpectrum of schizophreniaRecent-onset schizophreniaCerebellar vermisBrain functional connectivityPsychotic psychopathologyTotal vermisMDDSchizophreniaSubcortical regionsVisual learningFrontotemporal regionsPosterior vermisExploratory analysisDisordersCanonical correlationVermisFunctional alterationsNo significant associationSubregionsSignificant diagnosesEpigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder
Tang L, Zhao P, Pan C, Song Y, Zheng J, Zhu R, Wang F, Tang Y. Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder. Journal Of Affective Disorders 2024, 363: 249-257. PMID: 39029702, DOI: 10.1016/j.jad.2024.07.110.Peer-Reviewed Original ResearchMajor depressive disorderMajor depressive disorder patientsStructural-functional connectivityHPA axisDepressive disorderIncreased susceptibility to MDDSusceptibility to major depressive disorderMajor depressive disorder treatmentHealthy controlsStress-related disordersBrain network dynamicsMultimodal neuroimaging dataGender-matched healthy controlsSubcortical regionsNeuroimaging dataChronic stressCortical regionsNodal levelMedical statusFunctional networksCRHR1FKBP5CpG sitesDisordersMolecular underpinnings