Genome-Wide Association Study of Chronic Pain in Sickle Cell Disease
Sowa A, Hu Y, Gladwin M, Gordeuk V, Nouraie S, Zhang Y, Pashankar F, Krishnamurti L, Gruen J. Genome-Wide Association Study of Chronic Pain in Sickle Cell Disease. Blood 2024, 144: 5298. DOI: 10.1182/blood-2024-208093.Peer-Reviewed Original ResearchGenome-wide association studiesChronic painSickle cell diseaseGenome-wide association study studiesCHD2 geneGenome-wide significance thresholdAssociated with cognitive functionGenome-wide significancePatient-reported painStudy of chronic painModify chromatin structureFamily of genesSubtypes of sickle cell diseaseProportional odds logistic regressionHardy-Weinberg equilibriumChronic pain levelsCohort of individualsCell diseaseWell-phenotyped cohortAssociation of genetic polymorphismsEpisodes of acute painSickle cell disease patientsPopulation stratificationAtypical absence seizuresChromatin structure