Featured Publications
A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structure
2023
Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography
Oikonomou E, Holste G, Mcnamara R, Velazquez E, Nadkarni G, Ouyang D, Krumholz H, Wang Z, Khera R. Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography. European Heart Journal 2023, 44: ehad655.040. DOI: 10.1093/eurheartj/ehad655.040.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSevere aortic stenosisAortic stenosisAS progressionAV VmaxTransthoracic echocardiographyYale New Haven Health SystemBaseline left ventricular ejection fractionAortic stenosis progressionModerate aortic stenosisRetrospective cohort studyVentricular ejection fractionTwo-dimensional echocardiographyMean rateModerate ASAS severityCohort studyEjection fractionPatient sexStenosis progressionTTE studiesEligible participantsSerial monitoringSpecialized centersTimely diagnosis
2019
The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis
Papanastasiou CA, Kokkinidis DG, Kampaktsis PN, Bikakis I, Cunha DK, Oikonomou EK, Greenwood JP, Garcia MJ, Karamitsos TD. The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis. JACC Cardiovascular Imaging 2019, 13: 385-392. PMID: 31326491, DOI: 10.1016/j.jcmg.2019.03.029.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementAortic stenosisCardiac magnetic resonanceCause mortalityGadolinium enhancementLGE-CMRSystematic reviewA Systematic ReviewStrongest univariate predictorsRandom-effects modelBaseline characteristicsHazard ratioPrognostic roleRisk stratificationAdverse outcomesPrognostic valueUnivariate predictorsPooled analysisMyocardial fibrosisInclusion criteriaCardiac diseaseRegional fibrosisPatientsElectronic databasesMeta-Analysis