2017
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
Arnold P, Askland K, Barlassina C, Bellodi L, Bienvenu O, Black D, Bloch M, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Conti D, Cook E, Coric V, Cullen B, Cusi D, Davis L, Delorme R, Denys D, Derks E, Eapen V, Edlund C, Erdman L, Falkai P, Figee M, Fyer A, Geller D, Goes F, Grabe H, Grados M, Greenberg B, Grünblatt E, Guo W, Hanna G, Hemmings S, Hounie A, Jenicke M, Keenan C, Kennedy J, Khramtsova E, Konkashbaev A, Knowles J, Krasnow J, Lange C, Lanzagorta N, Leboyer M, Lennertz L, Li B, Liang K, Lochner C, Macciardi F, Maher B, Maier W, Marconi M, Mathews C, Matthesien M, McCracken J, McLaughlin N, Miguel E, Moessner R, Murphy D, Neale B, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Osiecki L, Pauls D, Piacentini J, Posthuma D, Pulver A, Qin H, Rasmussen S, Rauch S, Richter M, Riddle M, Ripke S, Ruhrmann S, Sampaio A, Samuels J, Scharf J, Shugart Y, Smit J, Stein D, Stewart S, Turiel M, Vallada H, Veenstra-VanderWeele J, Wagner M, Walitza S, Wang Y, Wendland J, Vulink N, Yu D, Zai G. Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis. Molecular Psychiatry 2017, 23: 1181-1188. PMID: 28761083, PMCID: PMC6660151, DOI: 10.1038/mp.2017.154.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCase-Control StudiesFemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceNeoplasm ProteinsObsessive-Compulsive DisorderPolymorphism, Single NucleotideReceptors, GlutamateRNA, Long NoncodingWhite PeopleConceptsGenome-wide association studiesSingle-nucleotide polymorphismsIOCDF-GCAssociation studiesOriginal genome-wide association studiesIndividualized genome-wide association studySingle-nucleotide polymorphism heritabilityIndividuals of European ancestryGenome-wide significanceGenome-wide studiesComplex genetic architectureSNP-based heritabilityGenetic association studiesPolygenic risk scoresLinkage peakCase-control statusMeta-analysisTop-ranked signalsHaplotype blocksDistribution of p-valuesPhenotypic varianceAllele frequenciesEuropean ancestryGenetic causeGenetics Collaborative
2013
Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Silgado J, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Restrepo S, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Duarte A, Vallada H, Van Nieuwerburgh F, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLOS Genetics 2013, 9: e1003864. PMID: 24204291, PMCID: PMC3812053, DOI: 10.1371/journal.pgen.1003864.Peer-Reviewed Original ResearchConceptsGenome-wide complex trait analysisExpression quantitative trait lociGenetic architectureGenetic correlationsGenome-wide common variant dataQuantitative trait lociComplex trait analysisDistinct genetic architecturesGenomic architectureGenomic elementsFunctional annotationMinor allele frequencyTrait lociPrevious heritability estimatesMAF binsGWAS studiesGene expressionTrait analysisHeritabilityGenetic overlapVariant dataHeritability estimatesAllele frequenciesCommon variationSNPs