2024
Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection.
Chen T, Marín-López A, Raduwan H, Fikrig E. Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection. MBio 2024, e0243324. PMID: 39373507, DOI: 10.1128/mbio.02433-24.Peer-Reviewed Original ResearchReceptor-like proteinZika virus infectionVirus infectionDevelopment of effective control strategiesSignificant public health challengeTranscriptome analysisTrypsin genesMetabolic pathwaysProtein signalingPublic health challengeViral infectionTransmission of viral diseasesAedes aegypti</i>InfectionBlood digestionZika virusProteinSignificance of signalsComplex interactionsVirusEffective control strategiesViral diseasesZikaMosquitoesPathway
2021
The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector
Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2021, 10: e72568. PMID: 34783654, PMCID: PMC8639152, DOI: 10.7554/elife.72568.Peer-Reviewed Original ResearchConceptsReceptor-mediated signalingAdiponectin receptorsAdiponectinLyme disease agentLyme disease spirochetePhospholipid metabolismPhosphatidylserine synthase ITick gutReceptor-like proteinMammalian homeostasisArthropod vectorsDisease agentsRNAi assaysRNA interferenceAlternative pathwaySynthase IPathwayMetabolic pathwaysTicksInfection